CD5 negative, cyclin D1-positive diffuse large B-cell lymphoma (DLBCL) presenting as ruptured spleen

Applied Immunohistochemistry and Molecular Morphology

Volumn 17, Issue 3, 2009, Pages 255-258

  Teruya Feldstein, Julie ^a   Gopalan, Anuradha ^a   Moskowitz, Craig H ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

CD5 negative; Cyclin D1 positive DLBCL; Pleomorphic mantle cell lymphoma; Splenic rupture

Indexed keywords

BORTEZOMIB; CARBOPLATIN; CD5 ANTIGEN; CYCLIN D1; CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; IFOSFAMIDE; KI 67 ANTIGEN; PREDNISONE; RITUXIMAB; VINCRISTINE; ANTINEOPLASTIC AGENT; MIB1 PROTEIN, HUMAN; PROTEIN P53; UBIQUITIN PROTEIN LIGASE;

ADULT; ANAPLASTIC CARCINOMA; ARTICLE; B CELL LYMPHOMA; CANCER CHEMOTHERAPY; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DIFFERENTIAL DIAGNOSIS; HUMAN; HUMAN TISSUE; LARGE CELL LYMPHOMA; LYMPHADENOPATHY; MALE; MANTLE CELL LYMPHOMA; MULTIPLE CYCLE TREATMENT; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SPLEEN RUPTURE; SPLENECTOMY; SPLENOMEGALY; FATALITY; MIDDLE AGED; RUPTURE;

ANTIGENS, CD5; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CYCLIN D1; DIAGNOSIS, DIFFERENTIAL; FATAL OUTCOME; HUMANS; LYMPHOMA, LARGE B-CELL, DIFFUSE; MALE; MIDDLE AGED; RUPTURE, SPONTANEOUS; SPLENIC RUPTURE; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES;

EID: 66549097996     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0b013e318182d2aa     Document Type: Article

References (20)

1. Bayerl MG, Bentley G, Bellan C, et al. Lacunar and Reed- Sternberg-like cells in follicular lymphomas are clonally related to the centrocytic and centroblastic cells as demonstrated by laser capture microdissection. Am J Clin Pathol. 2004;122:858-864. (Pubitemid 39577353)
2. Barry TS, Jaffe ES, Sorbara L, et al. Peripheral T-cell lymphomas expressing CD30 and CD15. Am J Surg Pathol. 2003;27:1513-1522. (Pubitemid 37486612)
3. Momose H, Jaffe ES, Shin SS, et al. Chronic lymphocytic leukemia/ small lymphocytic lymphoma with Reed-Sternberg-like cells and possible transformation to Hodgkin's disease. Mediation by Epstein-Barr virus. Am J Surg Pathol. 1992;16:859-867.
4. Williams J, Schned A, Cotelingam JD, et al. Chronic lymphocytic leukemia with coexistent Hodgkin's disease. Implications for the origin of the Reed-Sternberg cell. Am J Surg Pathol. 1991;15:33-42.
5. Tiemann M, Schrader C, Klapper W, et al. Histopathology, cell proliferation indices and clinical outcome in 304 patients with mantle cell lymphoma (MCL): a clinicopathological study from the European MCL Network. Br J Haematol. 2005;131:29-38. (Pubitemid 43899705)
6. Ott G, Kalla J, Ott MM, et al. Blastoid variants of mantle cell lymphoma: frequent bcl-1 rearrangements at the major translocation cluster region and tetraploid chromosome clones. Blood. 1997; 89:1421-1429. (Pubitemid 27080007)
7. Ek S, Bjorck E, Porwit-MacDonald A, et al. Increased expression of Ki-67 in mantle cell lymphoma is associated with de-regulation of several cell cycle regulatory components, as identified by global gene expression analysis. Haematologica. 2004;89:686-695. (Pubitemid 38828475)
8. Hernandez L, Fest T, Cazorla M, et al. p53 gene mutations and protein overexpression are associated with aggressive variants of mantle cell lymphomas. Blood. 1996;87:3351-3359. (Pubitemid 26115366)
9. Louie DC, Offit K, Jaslow R, et al. p53 overexpression as a marker of poor prognosis in mantle cell lymphomas with t(11;14)(q13;q32). Blood. 1995;86:2892-2899.
10. Pinyol M, Cobo F, Bea S, et al. p16(INK4a) gene inactivation by deletions, mutations, and hypermethylation is associated with transformed and aggressive variants of non-Hodgkin's lymphomas. Blood. 1998;91:2977-2984.
11. Katzenberger T, Petzoldt C, Holler S, et al. The Ki67 proliferation index is a quantitative indicator of clinical risk in mantle cell lymphoma. Blood. 2006;107:3407.
12. Salaverria I, Zettl A, Bea S, et al. Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature. J Clin Oncol. 2007;25:1216-1222. (Pubitemid 46640567)
13. - diffuse large B-cell lymphomas expresses nuclear cyclin D1 with aberrations at the CCND1 locus. Am J Clin Pathol. 2008;129: 630-638.
14. Smock KJ, Yaish HM, Cairo MS, et al. Mantle cell lymphoma presenting with unusual morphology in an adolescent female: a case report and review of the literature. Pediatr Dev Pathol. 2007;10: 403-408. (Pubitemid 350072216)
15. Norton AJ, Matthews J, Pappa V, et al. Mantle cell lymphoma: natural history defined in a serially biopsied population over a 20- year period. Ann Oncol. 1995;6:249-256.
16. Oinonen R, Franssila K, Elonen E. Spontaneous splenic rupture in two patients with a blastoid variant of mantle cell lymphoma. Ann Hematol. 1997;74:33-35. (Pubitemid 27050907)
17. Strickland AH, Marsden KA, McArdle J, et al. Pathologic splenic rupture as the presentation of mantle cell lymphoma. Leuk Lymphoma. 2001;41:197-201. (Pubitemid 32297590)
18. Lunning MA, Stetler-Stevenson M, Silberstein PT, et al. Spontaneous (pathological) splenic rupture in a blastic variant of mantle cell lymphoma: a case report and literature review. Clin Lymphoma. 2002;3:117-120. (Pubitemid 35277018)
19. Mason KD, Juneja SK. Spontaneous rupture of the spleen as the presenting feature of the blastoid variant of mantle cell lymphoma. Clin Lab Haematol. 2003;25:263-265.
20. Zieren J, Paul M, Scharfenberg M, et al. The spontaneous splenic rupture as first manifestation of mantle cell lymphoma, a dangerous rarity. Am J Emerg Med. 2004;22:629-631. (Pubitemid 40143260)