Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide γ-secretase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4708-4717

  Pu, Jun ^a   Kreft, Anthony F ^a   Aschmies, Suzan H ^a   Atchison, Kevin P ^a   Berkowitz, Joshua ^a   Caggiano, Thomas J ^a   Chlenov, Micheal ^a   Diamantidis, George ^a   Harrison, Boyd L ^a   Hu, Yun ^a   Huryn, Donna ^a   Steven Jacobsen, J ^a   Jin, Mei ^a   Lipinski, Kerri ^a   Lu, Peimin ^a   Martone, Robert L ^a   Morris, Koi ^a   Sonnenberg Reines, June ^a   Riddell, Dave R ^a   Sabalski, Joan ^a   Sun, Shaiu Ching ^a   Wagner, Erik ^a   Wang, Yiqun ^a   Xu, Zheng ^a   Zhou, Hua ^a   Resnick, Lynn ^a   more..

^a PFIZER INC   (United States)

Author keywords

Amyloid lowering agents; Secretase inhibitors; Alzheimer's disease

Indexed keywords

5 CHLORO N [2 ETHYL 1 [1 (4 HYDROXYBENZYL)PYRAZOL 5 YL]BUTYL]THIOPHENE 2 SULFONAMIDE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE INHIBITOR; N [N (3,5 DIFLUOROPHENACETYL)ALANYL]PHENYLGLYCINE TERT BUTYL ESTER; N2 [2 (3,5 DIFLUOROPHENYL) 2 HYDROXYACETYL] N1 (6,7 DIHYDRO 5 METHYL 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL)ALANINAMIDE; NOTCH RECEPTOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HETEROCYCLIC COMPOUNDS; HUMANS; MOLECULAR STRUCTURE; PROTEIN BINDING; RECEPTORS, NOTCH; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 66449122593     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.052     Document Type: Article

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