Polypurine hairpins directed against the template strand of DNA knock down the expression of mammalian genes

Journal of Biological Chemistry

Volumn 284, Issue 17, 2009, Pages 11579-11589

  de Almagro, M Cristina ^a   Coma, Silvia ^a,b   Noé, Véronique ^a   Ciudad, Carlos J ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER CELLS; CELL MORTALITY; DOUBLE STRANDS; ENZYMATIC ACTIVITIES; EXPERIMENTAL CONDITIONS; GENE TRANSCRIPTIONS; HUMAN BREAST CANCER CELLS; MAMMALIAN GENES; POLYPYRIMIDINE; SURVIVIN; TARGET SEQUENCES; TELOMERASE; TEMPLATE STRAND;

BIOACTIVITY; CELL CULTURE; CELL DEATH; CELL PROLIFERATION; DNA; GENES; MAMMALS; NUCLEIC ACIDS;

TRANSCRIPTION;

DIHYDROFOLATE REDUCTASE; DOUBLE STRANDED DNA; MESSENGER RNA; METHOTREXATE; POLYPURINE REVERSE HOOGSTEEN; PURINE; SURVIVIN; TELOMERASE; UNCLASSIFIED DRUG; BIRC5 PROTEIN, HUMAN; DNA; MICROTUBULE ASSOCIATED PROTEIN; PURINE DERIVATIVE;

ARTICLE; CANCER CELL CULTURE; CHEMICAL BOND; CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND; DNA TEMPLATE; DRUG DESIGN; DRUG DNA BINDING; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC MODEL; GENETIC TRANSFECTION; HALF LIFE TIME; HUMAN; HUMAN CELL; MOLECULAR STABILITY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; WATSON CRICK BOND; ANIMAL; BIOLOGICAL MODEL; CELL PROLIFERATION; CHEMISTRY; GENETIC PROCEDURES; GENETIC TRANSCRIPTION; METABOLISM; MOLECULAR GENETICS; TUMOR CELL LINE;

MAMMALIA;

ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; GENE EXPRESSION REGULATION; GENETIC TECHNIQUES; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PURINES; RNA, MESSENGER; TELOMERASE; TRANSCRIPTION, GENETIC;

EID: 66449106601     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M900981200     Document Type: Article

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