A simple, efficient, and selective deuteration via a flow chemistry approach

Tetrahedron Letters

Volumn 50, Issue 30, 2009, Pages 4372-4374

  Mándity, István M ^a   Martinek, Tamás A ^a   Darvas, Ferenc ^b   Fülöp, Ferenc ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b THALES   (France)

Author keywords

Deuteration; Flow chemistry; Heterogenous catalysis; Palladium; Reduction

Indexed keywords

DEUTERIUM;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHEMISTRY; CONTINUOUS FLOW REACTOR; HYDROGENATION; METHODOLOGY;

EID: 66449106178     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.05.050     Document Type: Article

References (21)

1. Stovkis E., Rosing H., and Beijnen J.H. Rapid Commun. Mass Spectrom. 19 (2005) 401
2. Zhou H., Ranish J.A., Watts J.D., and Aebersold R. Nat. Biotechnol. 20 (2002) 512
3. Baldwin J.E., Raghavan A.S., Hess B.A., and Smentek L. J. Am. Chem. Soc. 128 (2006) 14854
4. Kharasch E.D., Bedynek P.S., Park S., Ehittington D., Walker A., and Hoffer C. Clin. Pharmacol. Ther. 84 (2008) 497
5. Perrin C.L., and Lau J.S. J. Am. Chem. Soc. 128 (2006) 11820
6. Salzmann M., Pervushin K., Wider G., Senn H., and Wüthrich K. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 13585
7. Skaddan M.B., Yung C.M., and Bergman R.G. Org. Lett. 6 (2004) 11
8. In: Herber R.H. (Ed). Inorganic Isotopic Synthesis (1962), Benjamin, New York
9. Coppock J.B.M. Trans. Faraday Soc. 31 (1935) 913
10. Atzrodt J., Derdau V., Fey T., and Zimmermann J. Angew. Chem., Int. Ed. 119 (2007) 7890
11. Kovács G., Nádasai L., Laurenczy G., and Joó F. Green Chem. 5 (2003) 213
12. Kurita T., Aoki F., Mizumoto T., Maejima T., Esaki H., Maegawa T., Monguchi Y., and Sajiki H. Chem. Eur. J. 14 (2008) 3371
13. Kurita T., Hattori K., Seki S., Mizumoto T., Aoki F., Yamada Y., Ikawa K., Maegawa T., Monguchi Y., and Sajiki H. Chem. Eur. J. 14 (2008) 664
14. Maegawa T., Fujiwara Y., Inagaki Y., Esaki H., Monguchi Y., and Sajiki H. Angew. Chem., Int. Ed. 47 (2008) 5394
15. Csajági C., Borcsek B., Niesz K., Kovács I., Székelyhidi Z., Bajkó Z., Ürge L., and Darvas F. Org. Lett. 10 (2008) 1589
16. Continuous flow reactors: www.thalesnano.com, www.syrris.com.
17. Jones R.V., Godorhazy L., Varga N., Szalay D., Urge L., and Darvas F. J. Comb. Chem. 8 (2006) 110
18. Continuous flow hydrogenation instruments: www.thalesnano.com, www.syrris.com.
19. Appella D.H., Christianson L.A., Klein D.A., Powell D.R., Huang X.L., Barchi J.J., and Gellman S.H. Nature 387 (1997) 381
20. Martinek T.A., Hetényi A., Fülöp L., Mándity I.M., Tóth G.K., Dékány I., and Fülöp F. Angew. Chem., Int. Ed. 45 (2006) 2396
21. Mándity I.M., Wéber E., Martinek T.A., Olajos G., Tóth G.K., Vass E., and Fülöp F. Angew. Chem., Int. Ed. 48 (2009) 2171