Single nucleotide polymorphisms in monocyte chemoattractant protein-1 and its receptor act synergistically to increase the risk of carotid atherosclerosis

Cerebrovascular Diseases

Volumn 28, Issue 2, 2009, Pages 124-130

  Nyquist, Paul A ^a   Winkler, Cherie A ^b   McKenzie, Louise M ^b   Yanek, Lisa R ^a   Becker, Lewis C ^a   Becker, Diane M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Carotid atherosclerosis; Inflammation; Monocyte chemoattractant protein; Single nucleotide polymorphisms

Indexed keywords

CHEMOKINE RECEPTOR CCR2; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOCYTE CHEMOTACTIC PROTEIN 1;

ADULT; AFRICAN AMERICAN; AGE; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CAROTID ARTERY; CHOLESTEROL BLOOD LEVEL; CORONARY ARTERY DISEASE; DIABETES MELLITUS; ECHOGRAPHY; EDUCATION; FEMALE; GENDER; GENOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; VASCULAR DISEASE;

ADULT; AFRICAN AMERICANS; CAROTID ARTERY DISEASES; CHEMOKINE CCL2; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RECEPTORS, CCR2; RISK ASSESSMENT; RISK FACTORS; ULTRASONOGRAPHY, DOPPLER, DUPLEX;

EID: 66449105340     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000223437     Document Type: Article

References (41)

1. Brenner D, Labreuche J, Touboul PJ, Schmidt-Petersen K, Poirier O, Perret C, Schonfelder J, Combadiere C, Lathrop M, Cambien F, Brand-Herrmann SM, Amarenco P: Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. Stroke 2006;37:1691-1696. (Pubitemid 44297714)
2. Cha SH, Lee JY, Kim HT, Ryu HJ, Han BG, Kim JW, Oh B, Kimm K, Shin HD, Park BL, Park S, Park HY, Jang Y: Association of CCR2 polymorphisms with the number of closed coronary artery vessels in coronary artery disease. Clin Chim Acta 2007;38:129-133. (Pubitemid 46805085)
3. Iwai N, Kajimoto K, Kokubo Y, Okayama A, Miyazaki S, Nonogi H, Goto Y, Tomoike H: Assessment of genetic effects of polymorphisms in the MCP-1 gene on serum MCP-1 levels and myocardial infarction in Japanese. Circ J 2006;70:805-809. (Pubitemid 43979113)
4. Jemaa R, Rojbani H, Kallel A, Ben Ali S, Feki M, Chabrak S, Elasmi M, Taieb SH, Sanhaji H, Souheil O, Mechmeche R, Kaabachi N: Association between the -2518G/A polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene and myocardial infarction in Tunisian patients. Clin Chim Acta 2008;390:122-125.
5. Kim MP, Wahl LM, Yanek LR, Becker DM, Becker LC: A monocyte chemoattractant protein-1 gene polymorphism is associated with occult ischemia in a high-risk asymptomatic population. Atherosclerosis 2007;193:366-372.
6. McDermott DH, Yang Q, Kathiresan S, Cupples LA, Massaro JM, Keaney JF Jr, Larson MG, Vasan RS, Hirschhorn JN, O'Donnell CJ, Murphy PM, Benjamin EJ: CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study. Circulation 2005;112:1113-1120. (Pubitemid 41216117)
7. Ortlepp JR, Vesper K, Mevissen V, Schmitz F, Janssens U, Franke A, Hanrath P, Weber C, Zerres K, Hoffmann R: Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of age. J Mol Med 2003;81:363-367. (Pubitemid 36783240)
8. Petrkova J, Cermakova Z, Drabek J, Lukl J, Petrek M: CC chemokine receptor (CCR)2 polymorphism in Czech patients with myocardial infarction. Immunol Lett 2003;88:53-55. (Pubitemid 36835850)
9. Chen YL, Chang YJ, Jiang MJ: Monocyte chemotactic protein-1 gene and protein expression in atherogenesis of hypercholesterolemic rabbits. Atherosclerosis 1999;143:115-123. (Pubitemid 29138709)
10. Rovin BH, Lu L, Saxena R: A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression. Biochem Biophys Res Commun 1999;259:344-348. (Pubitemid 29281234)
11. Aiello RJ, Bourassa PA, Lindsey S, Weng W, Natoli E, Rollins BJ, Milos PM: Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 1999;19:1518-1525. (Pubitemid 29263023)
12. Boring L, Gosling J, Cleary M, Charo IF: Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 1998;394:894-897. (Pubitemid 28410911)
13. Dawson TC, Kuziel WA, Osahar TA, Maeda N: Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein Edeficient mice. Atherosclerosis 1999;143:205-211. (Pubitemid 29138720)
14. Furukawa Y, Matsumori A, Ohashi N, Shioi T, Ono K, Harada A, Matsushima K, Sasayama S: Anti-monocyte chemoattractant protein-1/monocyte chemotactic and activating factor antibody inhibits neointimal hyperplasia in injured rat carotid arteries. Circ Res 1999;84:306-314. (Pubitemid 29095571)
15. Yu X, Dluz S, Graves DT, Zhang L, Antoniades HN, Hollander W, Prusty S, Valente AJ, Schwartz CJ, Sonenshein GE: Elevated expression of monocyte chemoattractant protein 1 by vascular smooth muscle cells in hypercholesterolemic primates. Proc Natl Acad Sci USA 1992;89:6953-6957.
16. Zhang J, Ding X: Identification and characterization of a novel tissue-specific transcriptional activating element in the 5′-flanking region of the CYP2A3 gene predominantly expressed in rat olfactory mucosa. J Biol Chem 1998;273:23454-23462. (Pubitemid 28417536)
17. Bjarnadottir K, Eiriksdottir G, Aspelund T, Gudnason V: Examination of genetic effects of polymorphisms in the MCP-1 and CCR2 genes on MI in the Icelandic population. Atherosclerosis 2006;188:341-346. (Pubitemid 44301143)
18. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary. Expert panel on the identification, evaluation, and treatment of overweight in adults. Am J Clin Nutr 1998;68:899-917.
19. Cermakova Z, Petrkova J, Arakelyan A, Drabek J, Mrazek F, Lukl J, Petrek M: The MCP-1 -2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population. Int J Immunogenet 2005;32:315-318. (Pubitemid 41392376)
20. Ueda A, Ishigatsubo Y, Okubo T, Yoshimura T: Transcriptional regulation of the human monocyte chemoattractant protein-1 gene. Cooperation of two NF-kappaB sites and NF-kappaB/Rel subunit specificity. J Biol Chem 1997;272:31092-31099. (Pubitemid 27527558)
21. Amoli MM, Salway F, Zeggini E, Ollier WE, Gonzalez-Gay MA: MCP-1 gene haplotype association in biopsy proven giant cell arteritis. J Rheumatol 2005;32:507-510. (Pubitemid 40381423)
22. Modi WS, Goedert JJ, Strathdee S, Buchbinder S, Detels R, Donfield S, O'Brien SJ, Winkler C: MCP-1-MCP-3-eotaxin gene cluster influences HIV-1 transmission. Aids 2003;17:2357-2365. (Pubitemid 38147022)
23. Abecasis GR, Cardon LR, Cookson WO: A general test of association for quantitative traits in nuclear families. Am J Hum Genet 2000;66:279-292.
24. Horvath S, Xu X, Laird NM: The family based association test method: strategies for studying general genotype - phenotype associations. Eur J Hum Genet 2001;9:301-306. (Pubitemid 32366699)
25. Huber P: The behavior of maximum likelihood estimates under nonstandard conditions. Proc 5th Berkeley Symp Math Stat Probab, Berkeley, 1967.
26. Stephens M, Donnelly P: A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003;73:1162-1169. (Pubitemid 37414228)
27. Stephens M, Smith NJ, Donnelly P: A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001;68:978-989. (Pubitemid 32289743)
28. Barrett JC, Fry B, Maller J, Daly MJ: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-265. (Pubitemid 40202029)
29. Fatar M, Stroick M, Griebe M, Hennerici M: Matrix metalloproteinases in cerebrovascular diseases. Cerebrovasc Dis 2005;20:141-151.
30. Furukado S, Sakaguchi M, Yamagami H, Yagita Y, Hoshi T, Abe Y, Hougaku H, Hori M, Sakoda S, Kitagawa K: Cyclo-oxygenase-2 -765G > C promoter variants are associated with lower carotid plaque echogenicity in Japanese. Cerebrovasc Dis 2009;27:91-98.
31. Morrison AC, Bare LA, Luke MM, Pankow JS, Mosley TH, Devlin JJ, Willerson JT, Boerwinkle E: Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study. Cerebrovasc Dis 2008;26:420-424.
32. Worrall BB, Azhar S, Nyquist PA, Ackerman RH, Hamm TL, DeGraba TJ: Interleukin-1 receptor antagonist gene polymorphisms in carotid atherosclerosis. Stroke 2003;34:790-793. (Pubitemid 36307412)
33. Tabara Y, Kohara K, Yamamoto Y, Igase M, Nakura J, Kondo I, Miki T: Polymorphism of the monocyte chemoattractant protein (MCP-1) gene is associated with the plasma level of MCP-1 but not with carotid intimamedia thickness. Hypertens Res 2003;26:677-683. (Pubitemid 37258653)
34. D'Agostino RB Jr, Burke G, O'Leary D, Rewers M, Selby J, Savage PJ, Saad MF, Bergman RN, Howard G, Wagenknecht L, Haffner SM: Ethnic differences in carotid wall thickness. The insulin resistance atherosclerosis study. Stroke 1996;27:1744-1749.
35. Kennedy BS, Kasl SV, Brass LM, Vaccarino V: Trends in hospitalized stroke for blacks and whites in the United States, 1980-1999. Neuroepidemiology 2002;21:131-141.
36. Sacco RL, Boden-Albala B, Gan R, Chen X, Kargman DE, Shea S, Paik MC, Hauser WA: Stroke incidence among white, black, and Hispanic residents of an urban community: the Northern Manhattan Stroke Study. Am J Epidemiol 1998;147:259-268. (Pubitemid 28093136)
37. Stewart JA, Dundas R, Howard RS, Rudd AG, Wolfe CD: Ethnic differences in incidence of stroke: prospective study with stroke register. BMJ 1999;318:967-971. (Pubitemid 29189087)
38. White H, Boden-Albala B, Wang C, Elkind MS, Rundek T, Wright CB, Sacco RL: Ischemic stroke subtype incidence among whites, blacks, and Hispanics: the Northern Manhattan Study. Circulation 2005;111:1327-1331. (Pubitemid 40389099)
39. Bielinski SJ, Pankow JS, Miller MB, Hopkins PN, Eckfeldt JH, Hixson J, Liu Y, Register T, Myers RH, Arnett DK: Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI family heart study follow-up examination. Genes Immun 2007;8:684-690. (Pubitemid 350238439)
40. Rundek T, Elkind MS, Pittman J, Boden-Albala B, Martin S, Humphries SE, Juo SH, Sacco RL: Carotid intima-media thickness is associated with allelic variants of stromelysin-1, interleukin-6, and hepatic lipase genes: the Northern Manhattan Prospective Cohort Study. Stroke 2002;33:1420-1423. (Pubitemid 34517070)
41. Huang HY, Thuita L, Strickland P, Hoffman SC, Comstock GW, Helzlsouer KJ: Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population. BMC Genet 2007;8:7.