Biphasic activation of p38MAPK suggests that apoptosis is a downstream event in pemphigus acantholysis

Journal of Biological Chemistry

Volumn 284, Issue 18, 2009, Pages 12524-12532

  Lee, Hua En ^a,b   Berkowitz, Paula ^a   Jolly, Puneet S ^a   Diaz, Luis A ^a   Chua, Michael P ^b   Rubenstein, David S ^a,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; APOPTOTIC MARKERS; AUTOANTIBODIES; BIPHASIC; BLISTER FORMATION; CASPASE-3; CYTOSKELETAL; EPIDERMAL CELLS; INTRACELLULAR SIGNALING PATHWAYS; KERATINOCYTE; MOUSE MODELS; P38 MITOGEN-ACTIVATED PROTEIN KINASE; PEMPHIGUS VULGARIS; TEMPORAL RELATIONSHIPS; TIME COURSE;

ANTIGENS; CELL CULTURE; ENZYME ACTIVITY; PHOSPHORYLATION; TISSUE CULTURE;

CELL DEATH;

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AUTOANTIBODY; CASPASE 3; DESMOGLEIN 1 ANTIBODY; DESMOGLEIN 3 ANTIBODY; IMMUNOGLOBULIN G; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PROTEINASE; CASP3 PROTEIN, HUMAN; CASP3 PROTEIN, MOUSE; DESMOGLEIN 1; DESMOGLEIN 3; DSG3 PROTEIN, HUMAN; DSG3 PROTEIN, MOUSE; PROTEIN KINASE INHIBITOR;

ACANTHOLYSIS; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLISTER; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EPIDERMIS CELL; HUMAN; HUMAN CELL; KERATINOCYTE; MOUSE; NONHUMAN; PEMPHIGUS; PEMPHIGUS FOLIACEUS; PEMPHIGUS VULGARIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TISSUE CULTURE; ANIMAL; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TISSUE CULTURE TECHNIQUE;

ACANTHOLYSIS; ANIMALS; APOPTOSIS; AUTOANTIBODIES; CASPASE 3; CYTOSKELETON; DESMOGLEIN 1; DESMOGLEIN 3; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; HUMANS; IMMUNOGLOBULIN G; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEMPHIGUS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; TISSUE CULTURE TECHNIQUES;

EID: 66449087840     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808204200     Document Type: Article

References (43)

1. Anhalt, G. J., Labib, R. S., Voorhees, J. J., Beals, T. F., and Diaz, L. A. (1982) N. Engl. J. Med. 306, 1189-1196
2. Roscoe, J. T., Diaz, L., Sampaio, S. A., Castro, R. M., Labib, R. S., Takahashi, Y., Patel, H., and Anhalt, G. J. (1985) J. Investig. Dermatol. 85, 538-541
3. Amagai, M., Klaus-Kovtun, V., and Stanley, J. R. (1991) Cell 67, 869-877
4. Eyre, R. W., and Stanley, J. R. (1988) J. Clin. Investig. 81, 807-812
5. Ding, X., Aoki, V., Mascaro, J. M., Jr., Lopez-Swiderski, A., Diaz, L. A., and Fairley, J. A. (1997) J. Investig. Dermatol. 109, 592-596
6. Amagai, M., Tsunoda, K., Zillikens, D., Nagai, T., and Nishikawa, T. (1999) J. Am. Acad. Dermatol. 40, 167-170
7. Miyagawa, S., Amagai, M., Iida, T., Yamamoto, Y., Nishikawa, T., and Shirai, T. (1999) Br. J. Dermatol. 141, 1084-1087
8. Seishima, M., Esaki, C., Osada, K., Mori, S., Hashimoto, T., and Kitajima, Y. (1995) J. Investig. Dermatol. 104, 33-37
9. Waschke, J., Bruggeman, P., Baumgartner, W., Zillikens, D., and Drenckhahn, D. (2005) J. Clin. Investig. 115, 3157-3165
10. Waschke, J., Spindler, V., Bruggeman, P., Zillikens, D., Schmidt, G., and Drenckhahn, D. (2006) J. Cell Biol. 175, 721-727
11. Aoyama, Y., Owada, M. K., and Kitajima, Y. (1999) Eur. J. Immunol. 29, 2233-2240
12. Caldelari, R., de Bruin, A., Baumann, D., Suter, M. M., Bierkamp, C., Balmer, V., and Muller, E. (2001) J. Cell Biol. 153, 823-834
13. Calkins, C. C., Setzer, S. V., Jennings, J. M., Summers, S., Tsunoda, K., Amagai, M., and Kowalczyk, A. P. (2006) J. Biol. Chem. 281, 7623-7634
14. Delva, E., Jennings, J. M., Calkins, C. C., Kottke, M. D., Faundez, V., and Kowalczyk, A. P. (2008) J. Biol. Chem. 283, 18303-18313
15. Berkowitz, P., Hu, P., Liu, Z., Diaz, L. A., Enghild, J. J., Chua, M. P., and Rubenstein, D. S. (2005) J. Biol. Chem. 280, 23778-23784
16. Berkowitz, P., Hu, P., Warren, S., Liu, Z., Diaz, L. A., and Rubenstein, D. S. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 12855-12860
17. Berkowitz, P., Chua, M., Liu, Z., Diaz, L. A., and Rubenstein, D. S. (2008) Am. J. Pathol. 173, 1628-1636
18. Berkowitz, P., Diaz, L. A., Hall, R. P., and Rubenstein, D. S. (2008) J. Investig. Dermatol. 128, 738-740
19. Lavoie, J. N., Hickey, E., Weber, L. A., and Landry, J. (1993) J. Biol. Chem. 268, 24210-24214
20. Lavoie, J. N., Lambert, H., Hickey, E., Weber, L. A., and Landry, J. (1995) Mol. Cell. Biol. 15, 505-516
21. Guay, J., Lambert, H., Gingras-Breton, G., Lavoie, J. N., Huot, J., and Landry, J. (1997) J. Cell Sci. 110, 357-368
22. Perng, M. D., Cairns, L., van den, I. P., Prescott, A., Hutcheson, A. M., and Quinlan, R. A. (1999) J. Cell Sci. 112, 2099-2112
23. Feng, L., Zhou, X., Liao, J., and Omary, M. B. (1999) J. Cell Sci. 112, 2081-2090
24. Evgrafov, O. V., Mersiyanova, I., Irobi, J., Van Den Bosch, L., Dierick, I., Leung, C. L., Schagina, O., Verpoorten, N., Van Impe, K., Fedotov, V., Dadali, E., Auer-Grumbach, M., Windpassinger, C., Wagner, K., Mitrovic, Z., Hilton-Jones, D., Talbot, K., Martin, J. J., Vasserman, N., Tverskaya, S., Polyakov, A., Liem, R. K., Gettemans, J., Robberecht, W., De Jonghe, P., and Timmerman, V. (2004) Nat. Genet. 36, 602-606
25. Woll, S., Windoffer, R., and Leube, R. E. (2007) J. Cell Biol. 177, 795-807
26. Cuenda, A., and Rousseau, S. (2007) Biochim. Biophys. Acta 1773, 1358-1375
27. Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., and Greenberg, M. E. (1995) Science 270, 1326-1331
28. Juo, P., Kuo, C. J., Reynolds, S. E., Konz, R. F., Raingeaud, J., Davis, R. J., Biemann, H. P., and Blenis, J. (1997) Mol. Cell. Biol. 17, 24-35
29. Henkart, P. A. (1996) Immunity 4, 195-201
30. Nebreda, A. R., and Porras, A. (2000) Trends Biochem. Sci. 25, 257-260
31. Gniadecki, R., Jemec, G. B., Thomsen, B. M., and Hansen, M. (1998) Arch. Dermatol. Res. 290, 528-532
32. Wang, X., Bregegere, F., Frusic-Zlotkin, M., Feinmesser, M., Michel, B., and Milner, Y. (2004) Apoptosis 9, 131-143
33. Wang, X., Bregegere, F., Soroka, Y., Frusic-Zlotkin, M., and Milner, Y. (2004) FEBS Lett. 567, 281-286
34. Pelacho, B., Natal, C., Espana, A., Sanchez-Carpintero, I., Iraburu, M. J., and Lopez-Zabalza, M. J. (2004) FEBS Lett. 566, 6-10
35. Frusic-Zlotkin, M., Raichenberg, D., Wang, X., David, M., Michel, B., and Milner, Y. (2006) Autoimmunity 39, 563-575
36. Hu, P., O'Keefe, E. J., Berkowitz, P., and Rubenstein, D. S. (2001) J. Investig. Dermatol. 117, 481
37. Kawasaki, Y., Aoyama, Y., Tsunoda, K., Amagai, M., and Kitajima, Y. (2006) Autoimmunity 39, 587-590
38. Weiske, J., Schoneberg, T., Schroder, W., Hatzfeld, M., Tauber, R., and Huber, O. (2001) J. Biol. Chem. 276, 41175-41181
39. Dusek, R. L., Getsios, S., Chen, F., Park, J. K., Amargo, E. V., Cryns, V. L., and Green, K. J. (2006) J. Biol. Chem. 281, 3614-3624
40. Caulin, C., Salvesen, G. S., and Oshima, R. G. (1997) J. Cell Biol. 138, 1379-1394
41. Ku, N. O., Liao, J., and Omary, M. B. (1997) J. Biol. Chem. 272, 33197-33203
42. Amagai, M., Matsuyoshi, N., Wang, Z. H., Andl, C., and Stanley, J. R. (2000) Nat. Med. 6, 1275-1277
43. Hanakawa, Y., Schechter, N. M., Lin, C., Garza, L., Li, H., Yamaguchi, T., Fudaba, Y., Nishifuji, K., Sugai, M., Amagai, M., and Stanley, J. R. (2002) J. Clin. Investig. 110, 53-60