Nocathiacin analogs: Synthesis and antibacterial activity of novel water-soluble amides

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 13, 2009, Pages 3531-3535

  Xu, Libo ^a   Farthing, Amy K ^a   Dropinski, James F ^a   Meinke, Peter T ^a   McCallum, Christine ^a   Leavitt, Penny S ^a   Hickey, Emily J ^a   Colwell, Lawrence ^a   Barrett, John ^a   Liu, Kun ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antibacterial; Nocathiacin; Thiazolyl peptide; Water soluble

Indexed keywords

AMIDE; ANTIINFECTIVE AGENT; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; LINEZOLID; NOCATHIACIN ACID; NOCATHIACIN I; NOCATHIACIN I DERIVATIVE; UNCLASSIFIED DRUG; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DOG; DRUG CLEARANCE; DRUG HALF LIFE; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ENZYME INHIBITION; IC 50; MINIMUM INHIBITORY CONCENTRATION; MONKEY; MOUSE; NONHUMAN; REACTION ANALYSIS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; ANTI-BACTERIAL AGENTS; MICE; MICROBIAL SENSITIVITY TESTS; PEPTIDES; PIPERAZINES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 66349130687     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.144     Document Type: Article

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