Organic reactions in frozen water: Michael addition of amines and thiols to the dehydroalanine side chain of nocathiacins

Tetrahedron Letters

Volumn 45, Issue 5, 2004, Pages 1059-1063

  Naidu, B Narasimhulu ^a   Li, Wenying ^a   Sorenson, Margaret E ^a   Connolly, Timothy P ^a   Wichtowski, John A ^a   Zhang, Yunhui ^a   Kim, Oak K ^a   Matiskella, John D ^a   Lam, Kin S ^a   Bronson, Joanne J ^a   Ueda, Yasutsugu ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Dehydroalanine; Frozen water; Michael addition; Nocathiacins

Indexed keywords

AMINE; ANTIINFECTIVE AGENT; DEHYDROALANINE; NOCATHIACIN; THIOL DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ARTICLE; BACTERIAL STRAIN; COMPLEX FORMATION; DRUG STRUCTURE; FREEZING; GRAM POSITIVE BACTERIUM; MICHAEL ADDITION; REACTION ANALYSIS; STRUCTURE ANALYSIS;

POSIBACTERIA;

EID: 0345761239     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2003.11.081     Document Type: Article

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28. 2O: C, 45.38; H, 4.87; N, 12.21; S, 9.32; Cl, 5.15; found: C, 45.11; H, 4.71; N, 12.15; S, 9.25; Cl, 5.19.
29. Reactions were run using 0.1 mmol of 1 in 1 mL of de-ionized water.
30. The reaction was run using 5 mmol of 3 in 10 mL of de-ionozed water.