Human placental ectonucleoside triphosphate diphosphohydrolase gene transfer via gelatin-coated stents prevents in-stent thrombosis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 29, Issue 6, 2009, Pages 857-862

  Takemoto, Yasuhiro ^a   Kawata, Hiroyuki ^a   Soeda, Tsunenari ^a   Imagawa, Keiichi ^a   Somekawa, Satoshi ^a   Takeda, Yukiji ^a   Uemura, Shiro ^a   Matsumoto, Masanori ^a   Fujimura, Yoshihiro ^a   Jo, Jun Ichiro ^b   Kimura, Yu ^b   Tabata, Yasuhiko ^b   Saito, Yoshihiko ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Cationic gelatin; E NTPDase; Gene therapy; Platelets; Thrombosis

Indexed keywords

COMPLEMENTARY DNA; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE; ENZYME; GELATIN; MESSENGER RNA; UNCLASSIFIED DRUG; APYRASE; BIOMATERIAL; ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BALLOON; BARE METAL STENT; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; CORONARY STENT; ENZYME ACTIVATION; FEMORAL ARTERY; GENE; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; HYDROGEL; IMPLANTATION; INTIMA; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE FIBER; STENT THROMBOSIS; THROMBOCYTE AGGREGATION; THROMBOCYTE RICH PLASMA; THROMBUS; VASCULAR PATENCY; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; ENZYMOLOGY; FEMALE; GENE THERAPY; GENE VECTOR; GENETICS; HUMAN; HYPERPLASIA; INFLAMMATION; INJURY; INSTRUMENTATION; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PERIPHERAL VASCULAR DISEASE; PLACENTA; STENT; THROMBOSIS; TIME; VASCULAR SMOOTH MUSCLE;

ANGIOPLASTY, BALLOON; ANIMALS; APYRASE; CELL PROLIFERATION; COATED MATERIALS, BIOCOMPATIBLE; DISEASE MODELS, ANIMAL; FEMALE; FEMORAL ARTERY; GELATIN; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; HYPERPLASIA; INFLAMMATION; MALE; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE SYNTHASE TYPE III; PERIPHERAL VASCULAR DISEASES; PLACENTA; PLATELET AGGREGATION; RABBITS; STENTS; THROMBOSIS; TIME FACTORS; TUNICA INTIMA; VASCULAR PATENCY;

EID: 66349119617     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.109.186429     Document Type: Article

References (26)

1. Virmani R, Guagliumi G, Farb A, Musumeci G, Grieco N, Motta T, Mihalcsik L, Tespili M, Valsecchi O, Kolodgie FD. Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious? Circulation. 2004;109:701-705.
2. Joner M, Finn AV, Farb A, Mont EK, Kolodgie FD, Ladich E, Kutys R, Skorija K, Gold HK, Virmani R. Pathology of drug-eluting stents in humans. Delayed healing and late thrombotic risk. J Am Coll Cardiol. 2006;48:193-202.
3. Moses JW, Leon MB, Popma JJ, Fitzgerald PJ, Holmes DR, O'Shaughnessy C, Caputo RP, Kereiakes DJ, Williams DO, Teirstein PS, Jaeger JL, Kuntz RE, for the SIRIUS Investigators. Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med. 2003;349:1315-1323.
4. Johnson TW, Wu YX, Herdeg C, Baumbach A, Newby AC, Karsch KR, Oberhoff M. Stent-based delivery of tissue inhibitor of metalloproteinase-3 adenovirus inhibits neointimal formation in porcine coronary arteries. Arterioscler Thromb Vasc Biol. 2005;25:754-759.
5. Egashira K, Nakano K, Ohtani K, Funakoshi K, Zhao G, Ihara Y, Koga J, Kimura S, Tominaga R, Sunagawa K. Local delivery of anti-monocyte chemoattractant protein-1 by gene-eluting stents attenuates in-stent stenosis in rabbits and monkeys. Arterioscler Thromb Vasc Biol. 2007;27: 2563-2568.
6. Farb A, Sangiorgi G, Carter AJ, Walley VM, Edwards WD, Schwartz RS, Virmani R. Pathology of acute and chronic coronary stenting in humans. Circulation. 1999;99:44-52.
7. Gawaz M. Role of platelets in coronary thrombosis and reperfusion of ischemic myocardium. Cardiovasc Res. 2004;61:498-511.
8. Gordon EL, Pearson JD, Slakey LL. The hydrolysis of extracellular adenosine nucleotides by cultured endothelial cells from pig aorta. J Biol Chem. 1986;261:15496-15504.
9. Pearson JD, Gordon JL. Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides. Nature. 1979;281:384-386.
10. Zimmermann H. 5′-Nucleotidase: molecular structure and functional aspects. Biochem J. 1992;285:345-365.
11. Gachet C. ADP receptors of platelets and their inhibition. Thromb Haemost. 2001;6:222-232.
12. Leopold JA, Antman EM. Dual antiplatelet therapy for coronary stenting: a clear path for a research agenda. Circulation. 2005;111:1097-1099.
13. Gurbel PA, Bliden KP, Samara W, Yoho JA, Hayes K, Fissha MZ, Tantry US. Clopidogrel effect on platelet reactivity in patients with stent thrombosis. Results of the CREST study. J Am Coll Cardiol. 2005;46: 1827-1832.
14. Marcus AJ, Johan Broekman M, Drosopoulos JH, Islam N, Alyonycheva TN, Safier LB, Hajjar KA, Posnett DN, Schoenborn MA, Schooley KA, Gayle RB, Maliszewski CR. The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39. J Clin Invest. 1997;99:1351-1360.
15. Schulte am Esch JII, Sévigny J, Kaczmarek E, Siegel JB, Imai M, Koziak K, Beaudoin AR, Robson SC. Structural elements and limited proteolysis of CD39 influence ATP diphosphohydrolase activity. Biochemistry. 1999;38:2248-2258.
16. Makita K, Shimoyama T, Sakurai Y, Yagi H, Matsumoto M, Narita N, Sakamoto Y, Saito S, Ikeda Y, Suzuki M, Titani K, Fujimura Y. Placental ecto-ATP diphosphohydrolase: its structural feature distinct from CD39, localization and inhibition on shear-induced platelet aggregation. Int J Hematol. 1998;68:297-310.
17. Matsumoto M, Sakurai Y, Kokubo T, Yagi H, Makita K, Matsui T, Titani K, Fujimura Y, Narita N. The cDNA cloning of human placental ecto-ATP diphosphohydrolases I and II. FEBS Lett. 1999;453:335-340.
18. Furukoji E, Matsumoto M, Yamashita A, Yagi H, Sakurai Y, Marutsuka K, Hatakeyama K, Morishita K, Fujimura Y, Tamura S, Asada Y. Adenovirus-mediated transfer of human placental ectonucleoside triphosphate diphosphohydrolase to vascular smooth muscle cells suppresses platelet aggregation in vitro and arterial thrombus formation in vivo. Circulation. 2005;111:808-815.
19. Yamashita A, Furukoji E, Marutsuka K, Hatakeyama K, Yamamoto H, Tamura S, Ikeda Y, Sumiyoshi A, Asada Y. Increased vascular wall thrombogenicity combined with reduced blood flow promotes occlusive thrombus formation in rabbit femoral artery. Arterioscler Thromb Vasc Biol. 2004;24:2420-2424.
20. Kawata H, Naya N, Takemoto Y, Uemura S, Nakajima T, Horii M, Takeda Y, Fujimoto S, Yamashita A, Asada Y, Saito Y. Ultrasound accelerates thrombolysis of acutely induced platelet-rich thrombi similar to those in acute myocardial infarction. Circ J. 2007;71:1643-1648.
21. Kushibiki T, Tomoshige R, Fukunaka Y, Kakemi M, Tabata Y. In vivo release and gene expression of plasmid DNA by hydrogels of gelatin with different cationization extents. J Control Release. 2003;90:207-216.
22. Imai M, Takigami K, Guckelberger O, Kaczmarek E, Csizmadia E, Bach FH, Robson SC. Recombinant adenoviral mediated CD39 gene transfer prolongs cardiac xenograft survival. Transplantation. 2000;70:864-870.
23. Dwyer KM, Robson SC, Nandurkar HH, Campbell DJ, Gock H, Murray-Segal LJ, Fisicaro N, Mysore TB, Kaczmarek E, Cowan PJ, d'Apice AJ. Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation. J Clin Invest. 2004;113:1440-1446.
24. Goepfert C, Sundberg C, Sévigny J, Enjyoji K, Hoshi T, Csizmadia E, Robson S. Disordered cellular migration and angiogenesis in cd39-null mice. Circulation. 2001;104:3109-3115.
25. Mizumoto N, Kumamoto T, Robson SC, Sevigny J, Matsue H, Enjyoji K, Takashima A. CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness. Nature Med. 2002;8:358-365.
26. Luuscher TF, Steffel J, Eberli FR, Joner M, Nakazawa G, Tanner FC, Virmani R. Drug-eluting stent and coronary thrombosis: biological mechanisms and clinical implications. Circulation. 2007;115:1051-1058.