Synthesis and in vitro study of a new class of methylenebis-4,6- diarylbenzo[d]isoxazoles as potential antifungal agents

Journal of Heterocyclic Chemistry

Volumn 46, Issue 3, 2009, Pages 497-502

  Srinivas, A ^a   Nagaraj, A ^a   Sanjeeva Reddy, Ch ^a  

^a KAKATIYA UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

2 [6 (2 FURYL)BENZO[D]ISOXAZOL 4 YL] 4 3 [6 (2 FURYL)BENZO[D]ISOXAZOL 4 YL] 4 HYDROXYBENZYLPHENOL; 2 [6 (4 AMINOPHENYL)BENZO[D]ISOXAZOL 4 YL] 4 3 [6 (4 AMINOPHENYL)BENZO[D]ISOXAZOL 4 YL] 4 HYDROXYBENZYLPHENOL; 2 [6 (4 BROMOPHENYL)BENZO[D]ISOXAZOL 4 YL] 4 3 [6 (4 BROMOPHENYL)BENZO[D]ISOXAZOL 4 YL] 4 HYDROXYBENZYLPHENOL; 2 [6 (4 CHLOROPHENYL)BENZO[D]ISOXAZOL 4 YL] 4 3 [6 (4 CHLOROPHENYL)BENZO[D]ISOXAZOL 4 YL] 4 HYDROXYBENZYLPHENOL; 4 4 HYDROXY 3 [6 (1,3 THIAZOL 5 YL)BENZO[D]ISOXAZOL 4 YL]BENZYL 2 [6 (1,3 THIAZOL 5 YL)BENZO[D]ISOXAZOL 4 YL]PHENOL; 4 4 HYDROXY 3 [6 (2 PYRAZINYL)BENZO[D]ISOXAZOL 4 YL]BENZYL 2 [6 (2 PYRAZINYL)BENZO[D]ISOXAZOL 4 YL]PHENOL; 4 4 HYDROXY 3 [6 (2 PYRIDYL)BENZO[D]ISOXAZOL 4 YL]BENZYL 2 [6 (2 PYRIDYL)BENZO[D]ISOXAZOL 4 YL]PHENOL; 4 4 HYDROXY 3 [6 (4 METHOXYPHENYL)BENZO[D]ISOXAZOL 4 YL]BENZYL 2 [6 (4 METHOXYPHENYL)BENZO[D]ISOXAZOL 4 YL]PHENOL; 4 [4 HYDROXY 3 (6 PHENYLBENZO[D]ISOXAZOL 4 YL)BENZYL] 2 (6 PHENYLBENZO[D]ISOXAZOL 4 YL)PHENOL; AMPHOTERICIN B; ANTIFUNGAL AGENT; BENZOQUINONE DERIVATIVE; CYCLOHEXENE DERIVATIVE; HYDROXYLAMINE; ISOXAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; AROMATIZATION; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TRICHOPHYTON MENTAGROPHYTES; TRICHOPHYTON RUBRUM;

EID: 66349114758     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.100     Document Type: Article

References (40)

1. De Logu, A.; Saddi, M.; Cardia, M. C.; Borgna, R.; Sanna, C.; Saddi, B.; Maccioni, E. J Antimicrob Chemother 2005, 55, 692.
2. (a) Desai, J. T.; Desai, C. K.; Desai, K. R. J Iran Chem Soc 2008, 5, 67;
3. (b) Basawaraj, R.; Ahmad, A.; Omkar, K.; Sangapure, S. S. Indian J Heterocycl Chem 2007, 17, 11.
4. Rajeshwar, N.; Marcus, P.; Stefanie, L.; Karlheinz, B.; Sabine, K.; Thomas, D.; Sascha, W.; Eckhard, M.; Boris, S. Chem Med Chem 2008, 3, 165.
5. Cho, S. Y.; Ahn, J. H.; Ha, J. D.; Kang, S. K.; Back, J. Y.; Han, S. S.; Shin, E. Y.; Kim, S. S.; Kim, K. R.; Cheon, H. G.; Choi, J. K. Bull Korean Chem Soc 2003, 24, 1455.
6. Schmidt, J.; Widmann, K. Lab Pure and Pharm; Lem Royal Technochschule: Stultgart Bet, 1908; Vol.41, p 1252.
7. Hansen, J. F.; Strong, S. A. J Heterocycl Chem 1977, 14, 1289.
8. Tayade, V. B.; Jamode, V. S. Asian J Chem 1997, 9, 866.
9. Balalaie, S.; Sharifi, A.; Ahangarian, B. Indian J Heterocycl Chem 2000, 10, 149.
10. (a) Tibor, M.; Neil, P. S.; Henry Gount, S. P. PCT Int Appl WO 9414, 782;
11. (b) Holla, B. S.; Ambekar, S. Y. J Indian Chem Soc 1973, 50, 673.
12. Kachhadia, V. V.; Patel, M. R.; Joshi, H. S. J Sci Islamic Republic of Iran, 2004, 15, 47.
13. Marcin, M.; Michal, Z.; Ewa, D. S.; Stanislaw, R. Cell Mol Biol Lett 2005, 10, 613.
14. Nagar, N. R.; Shan, V. H.; Mehta, T. Indian J Heterocycl Chem 2003, 13, 173.
15. Dannhardt, G.; Kiefer, W.; Kramer, G.; Maehrlein, S.; Nowe, U.; Fiebich, B. Eur J Med Chem 2000, 35, 499.
16. (a) Gaziz, M. H.; Hosseir, N. L.; Doss, A. S.; Rock, S. Indian J Chem 1976, 14B, 286;
17. (b) Witezak, A.; Mrolikowaska, M. Pol J Chem 1981, 55, 89;
18. (c) Lohiya, S. B.; Ghiya, B. J. Indian J Chem 1986, 25B, 279.
19. (a) Adam, G. M.; Christopher, J. E.; Stephen, F. L.; Gregory, W. S. J Org Chem 1998, 63, 9069;
20. (b) Robert, E.; Sammelson, R.; Bryan, M.; Mark, J. K. J Org Chem 2000, 65, 2225;
21. (c) Trond, V. H.; Peng, W.; Valery, V. F. J Org Chem 2005, 70, 7761.
22. (a) Claisen, L. Ber 1903, 36, 3664;
23. (b) Claisen, L. Ber 1909, 42, 59.
24. Padmavathi, V.; Jagan Mohan Reddy, B.; Balaiah, A.; Venugopal Reddy, K.; Bhaskar Reddy, D. Molecules 2000, 5, 1281.
25. (a) Smitha, G.; Sanjeeva Reddy, Ch. Synth Commun 2004, 34, 3997;
26. (b) Smitha, G.; Sanjeeva Reddy, Ch. Synth Commun 2006, 36, 1795;
27. (c) Sanjeeva Reddy, Ch.; Nagaraj, A. Heterocycl Commun 2007, 13, 67;
28. (d) Sanjeeva Reddy, Ch.; Nagaraj, A. Chin Chem Lett 2007, 18, 1431;
29. (e) Sanjeeva Reddy, Ch.; Nagaraj, A.; Jalapathi, P. Chin Chem Lett 2007, 18, 1213;
30. (f) Nagaraj, A.; Sanjeeva Reddy, Ch. J Heterocycl Chem 2007, 44, 1357;
31. (g) Nagaraj, A.; Sanjeeva Reddy, Ch. J Heterocycl Chem 2007, 44, 1181;
32. (h) Sanjeeva Reddy, Ch.; Nagaraj, A. Indian J Chem 2008, 47B, 319;
33. (i) Nagaraj, A.; Sanjeeva Reddy, Ch. J Iran Chem Soc 2008, 5, 262;
34. (j) Srinivas, A.; Nagaraj, A.; Sanjeeva Reddy, Ch. Indian J Chem 2008, 47B, 787;
35. (k) Srinivas, A.; Nagaraj, A.; Sanjeeva Reddy, Ch. J Heterocycl Chem 2008, 45, 999;
36. (l) Srinivas, A.; Nagaraj, A.; Sanjeeva Reddy, Ch. J Heterocycl Chem 2008, 45, 1121;
37. (m) Raghu, M.; Nagaraj, A.; Sanjeeva Reddy, Ch. J Heterocycl Chem 2008, 45, 1115;
38. (n) Sanjeeva Reddy, Ch.; Nagaraj, A. Indian J Chem 2008, 47B, 1154.
39. Marvel, C. S.; Tarkoy, N. J Am Chem Soc 1957, 79, 6000.
40. National Committee for Clinical Laboratory Standards (NCCLs). Standard Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria, Which Grows Aerobically; National Committee for Clinical Laboratory Standards: Villanova, 1982; p 242.