Synthesis and antibacterial activity of some novel imidazole-based dicationic quinolinophanes

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 13, 2009, Pages 3466-3470

  Rajakumar, Perumal ^a   Raja, Rathinam ^a   Selvam, Subramaniyan ^a   Rengasamy, Ramasamy ^a   Nagaraj, Subramani ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Antibacterial activity; Chiral cyclophanes; Dicationic quinolinophanes

Indexed keywords

IMIDAZOLE; QUINOLINE; QUINOLINOPHANE DERIVATIVE; STREPTOMYCIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; PSEUDOMONAS AERUGINOSA; SHIGELLA; STAPHYLOCOCCUS AUREUS; VIBRIO CHOLERAE;

ANTI-BACTERIAL AGENTS; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; QUINOLINES;

EID: 66349091256     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.019     Document Type: Article

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43. Antibacterial activity: Antibacterial activity of the cyclophanes against the selected human pathogens was evaluated by the agar well diffusion method. About 1 ml of inoculums of each test pathogen was added to the molten NA medium and poured into sterile Petri plates under aseptic conditions. After solidification, a 5 mm well was made in four wells of each plate using a sterile cork borer. Each compound was dissolved in 10% DMSO to get different concentrations and filtered using 0.25 μm sterilized filter paper. Each well received 50 μl solutions of each compound and the plates incubated at room temperature. Sterile DMSO (10%) was used as control. After 48 h, the appearance of inhibition zone around the well was observed. The plates were incubated overnight at 37 °C. Microbial growth was determined by measuring the minimum inhibitory concentration in μl/ml. For each bacterial strain, controls and commercial antibiotics were maintained.