메뉴 건너뛰기




Volumn 75, Issue 11, 2009, Pages 3808-3812

Molecular diversification in the quorum-sensing system of Vibrio cholerae: Role of natural selection in the emergence of pandemic strains

Author keywords

[No Author keywords available]

Indexed keywords

HAPLOTYPES; NATURAL SELECTION; PANDEMIC STRAINS; QUORUM-SENSING SYSTEMS; VIBRIO CHOLERAE;

EID: 66249125662     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.02496-08     Document Type: Article
Times cited : (9)

References (54)
  • 1
    • 33644784801 scopus 로고    scopus 로고
    • Evidence for a selective sweep in the wapl region of Drosophila melanogaster
    • Beisswanger, S., W. Stephan, and D. De Lorenzo. 2005. Evidence for a selective sweep in the wapl region of Drosophila melanogaster. Genetics 172:265-274.
    • (2005) Genetics , vol.172 , pp. 265-274
    • Beisswanger, S.1    Stephan, W.2    De Lorenzo, D.3
  • 4
    • 0028847868 scopus 로고
    • Genesis of the novel epidemic Vibrio cholerae O139 strains: Evidence for horizontal transfer of genes involved in polysaccharide synthesis
    • Bik, E. M., A. E. Bunschoten, R. D. Gouw, and F. R. Mooi. 1995. Genesis of the novel epidemic Vibrio cholerae O139 strains: evidence for horizontal transfer of genes involved in polysaccharide synthesis. EMBO J. 14:209-216.
    • (1995) EMBO J. , vol.14 , pp. 209-216
    • Bik, E.M.1    Bunschoten, A.E.2    Gouw, R.D.3    Mooi, F.R.4
  • 5
    • 34347354390 scopus 로고    scopus 로고
    • Serogroup conversion of Vibrio cholerae in aquatic reservoirs
    • Blokesch, M., and G. K. Schoolnik. 2007. Serogroup conversion of Vibrio cholerae in aquatic reservoirs. PloS Pathog. 3:733-742.
    • (2007) PloS Pathog. , vol.3 , pp. 733-742
    • Blokesch, M.1    Schoolnik, G.K.2
  • 6
    • 0035987249 scopus 로고    scopus 로고
    • Evolutionary and functional analyses of variants of the toxin-coregulated pilus protein TcpA from toxigenic Vibrio cholerae non-O1/non-O139 serogroup isolates
    • Boyd, E. F., and M. K. Waldor. 2002. Evolutionary and functional analyses of variants of the toxin-coregulated pilus protein TcpA from toxigenic Vibrio cholerae non-O1/non-O139 serogroup isolates. Microbiology 148:1655-1666.
    • (2002) Microbiology , vol.148 , pp. 1655-1666
    • Boyd, E.F.1    Waldor, M.K.2
  • 7
    • 0031931505 scopus 로고    scopus 로고
    • Ordered cloned DNA map of the genome of Vibrio cholerae 569B and localization of genetic markers
    • Chatterjee, S., A. K. Mondal, N. A. Begum, S. Roychoudhury, and J. Das. 1998. Ordered cloned DNA map of the genome of Vibrio cholerae 569B and localization of genetic markers. J. Bacteriol. 180:901-908.
    • (1998) J. Bacteriol. , vol.180 , pp. 901-908
    • Chatterjee, S.1    Mondal, A.K.2    Begum, N.A.3    Roychoudhury, S.4    Das, J.5
  • 9
    • 0037022337 scopus 로고    scopus 로고
    • Comparative genomic analysis of Vibrio cholerae: Genes that correlate with cholera endemic and pandemic disease
    • Dziejman, M., E. Balon, D. Boyd, C. M. Fraser, J. F. Heidelberg, and J. J. Mekalanos. 2002. Comparative genomic analysis of Vibrio cholerae: genes that correlate with cholera endemic and pandemic disease. Proc. Natl. Acad. Sci. USA 99:1556-1561.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 1556-1561
    • Dziejman, M.1    Balon, E.2    Boyd, D.3    Fraser, C.M.4    Heidelberg, J.F.5    Mekalanos, J.J.6
  • 11
    • 0242321088 scopus 로고    scopus 로고
    • Pathogenicity islands and phages in Vibrio cholerae evolution
    • Faruque, S. M., and J. J. Mekalanous. 2003. Pathogenicity islands and phages in Vibrio cholerae evolution. Trends Microbiol. 11:505-510.
    • (2003) Trends Microbiol. , vol.11 , pp. 505-510
    • Faruque, S.M.1    Mekalanous, J.J.2
  • 13
    • 0020053230 scopus 로고
    • Purification and characterization of the soluble hemagglutinin (cholera lectin) produced by Vibrio cholerae
    • Finkelstein, R. A., and L. F. Hanne. 1982. Purification and characterization of the soluble hemagglutinin (cholera lectin) produced by Vibrio cholerae. Infect. Immun. 36:1199-1208.
    • (1982) Infect. Immun. , vol.36 , pp. 1199-1208
    • Finkelstein, R.A.1    Hanne, L.F.2
  • 14
    • 0026332855 scopus 로고
    • Vibrio cholerae hemagglutinin/protease, colonial variation, virulence, and detachment
    • Finkelstein, R. A., M. Boesman-Finkelstein, Y. Chang, and C. C. Häse. 1992. Vibrio cholerae hemagglutinin/protease, colonial variation, virulence, and detachment. Infect. Immun. 60:472-478.
    • (1992) Infect. Immun. , vol.60 , pp. 472-478
    • Finkelstein, R.A.1    Boesman-Finkelstein, M.2    Chang, Y.3    Häse, C.C.4
  • 15
    • 0037710467 scopus 로고    scopus 로고
    • Molecular epidemiology of O139 Vibrio cholerae: Mutation, lateral gene transfer, and founder flush
    • Garg, P., A. Aydanian, D. Smith, J. G. Morris, Jr., G. B. Nair, and O. C. Stine. 2003. Molecular epidemiology of O139 Vibrio cholerae: mutation, lateral gene transfer, and founder flush. Emerg. Infect. Dis. 9:810-814.
    • (2003) Emerg. Infect. Dis. , vol.9 , pp. 810-814
    • Garg, P.1    Aydanian, A.2    Smith, D.3    Morris Jr., J.G.4    Nair, G.B.5    Stine, O.C.6
  • 16
    • 0022521415 scopus 로고
    • Cloning of the Vibrio cholerae recA gene and construction of a Vibrio cholerae recA mutant
    • Goldberg, I., and J. J. Mekalanos. 1986. Cloning of the Vibrio cholerae recA gene and construction of a Vibrio cholerae recA mutant. J. Bacteriol. 165:715-722.
    • (1986) J. Bacteriol. , vol.165 , pp. 715-722
    • Goldberg, I.1    Mekalanos, J.J.2
  • 17
    • 0141707658 scopus 로고    scopus 로고
    • Quorum sensing controls biofilm formation in Vibrio cholerae
    • Hammer, B. K., and B. L. Bassler. 2003. Quorum sensing controls biofilm formation in Vibrio cholerae. Mol. Microbiol. 50:101-114.
    • (2003) Mol. Microbiol. , vol.50 , pp. 101-114
    • Hammer, B.K.1    Bassler, B.L.2
  • 18
    • 0022655091 scopus 로고
    • Plasmid-mediated changes in virulence of Vibrio cholerae
    • Hamood, A. N., R. D. Sublett, and C. D. Parker. 1986. Plasmid-mediated changes in virulence of Vibrio cholerae. Infect. Immun. 52:476-483.
    • (1986) Infect. Immun. , vol.52 , pp. 476-483
    • Hamood, A.N.1    Sublett, R.D.2    Parker, C.D.3
  • 19
    • 0027944329 scopus 로고
    • Genetic characterization of mannose-sensitive hemagglutinin (MSHA)-negative mutants of Vibrio cholerae derived by Tn5 mutagenesis
    • Häse, C. C., M. E. Bauer, and R. A. Finkelstein. 1994. Genetic characterization of mannose-sensitive hemagglutinin (MSHA)-negative mutants of Vibrio cholerae derived by Tn5 mutagenesis. Gene 150:17-25.
    • (1994) Gene , vol.150 , pp. 17-25
    • Häse, C.C.1    Bauer, M.E.2    Finkelstein, R.A.3
  • 20
    • 0035692320 scopus 로고    scopus 로고
    • Two-locus sampling distributions and their application
    • Hudson, R. R. 2001. Two-locus sampling distributions and their application. Genetics 159:1805-1817. (Pubitemid 34087616)
    • (2001) Genetics , vol.159 , Issue.4 , pp. 1805-1817
    • Hudson, R.R.1
  • 21
    • 0036184745 scopus 로고    scopus 로고
    • Generating samples under a Wright-Fisher neutral model of genetic variation
    • Hudson, R. R. 2002. Generating samples under a Weight-Fisher neutral model of genetic variation. Bioinformatics 18:337-338. (Pubitemid 34183119)
    • (2002) Bioinformatics , vol.18 , Issue.2 , pp. 337-338
    • Hudson, R.R.1
  • 22
    • 0022211482 scopus 로고
    • Statistical properties of the number of recombination events in the history of a sample of DNA sequences
    • Hudson, R. R., and N. L. Kaplan. 1985. Statistical properties of the number of recombination events in the history of a sample of DNA sequences. Genetics 111:147-164. (Pubitemid 16248827)
    • (1985) Genetics , vol.111 , Issue.1 , pp. 147-164
    • Hudson, R.R.1    Kaplan, N.L.2
  • 23
    • 31844439534 scopus 로고    scopus 로고
    • Genetic and phenotypic diversity of quorum-sensing systems in clinical and environmental isolates of Vibrio cholerae
    • DOI 10.1128/IAI.74.2.1141-1147.2006
    • Joelsson, A., Z. Liu, and J. Zhu. 2006. Genetic and phenotypic diversity of quorum-sensing systems in clinical and environmental isolates of Vibrio cholerae. Infect. Immun. 74:1141-1147. (Pubitemid 43185552)
    • (2006) Infection and Immunity , vol.74 , Issue.2 , pp. 1141-1147
    • Joelsson, A.1    Liu, Z.2    Zhu, J.3
  • 24
    • 34249908150 scopus 로고    scopus 로고
    • Quorum sensing enhances the stress response in Vibrio cholerae
    • Joelsson, A., B. Kan, and J. Zhu. 2007. Quorum sensing enhances the stress response in Vibrio cholerae. Appl. Environ. Microbiol. 73:3742-3746.
    • (2007) Appl. Environ. Microbiol. , vol.73 , pp. 3742-3746
    • Joelsson, A.1    Kan, B.2    Zhu, J.3
  • 26
    • 34249875438 scopus 로고    scopus 로고
    • Genomic and phenotypic diversity of coastal Vibrio cholerae strains is linked to environmental factors
    • Keymer, D. P., M. C. Miller, G. K. Schoolnik, and A. B. Boehm. 2007. Genomic and phenotypic diversity of coastal Vibrio cholerae strains is linked to environmental factors. Appl. Environ. Microbiol. 73:3705-3714.
    • (2007) Appl. Environ. Microbiol. , vol.73 , pp. 3705-3714
    • Keymer, D.P.1    Miller, M.C.2    Schoolnik, G.K.3    Boehm, A.B.4
  • 27
    • 0036189827 scopus 로고    scopus 로고
    • Detecting a local signature of genetic hitchhiking along a recombining chromosome
    • Kim, Y., and W. Stephan. 2002. Detecting a local signature of genetic hitchhiking along a recombining chromosome. Genetics 160:765-777. (Pubitemid 34194545)
    • (2002) Genetics , vol.160 , Issue.2 , pp. 765-777
    • Kim, Y.1    Stephan, W.2
  • 28
    • 42049089720 scopus 로고    scopus 로고
    • Rapid growth of planktonic Vibrio cholerae non-O1/non-O139 strains in a large alkaline lake in Austria: Dependence on temperature and dissolved organic carbon quality
    • Kirscher, A. K., J. Schlesinger, A. H. Farnleitner, R. Hornek, B. Süß, B. Golda, A. Herzig, and B. Reitner. 2008. Rapid growth of planktonic Vibrio cholerae non-O1/non-O139 strains in a large alkaline lake in Austria: dependence on temperature and dissolved organic carbon quality. Appl. Environ. Microbiol. 74:2004-2015.
    • (2008) Appl. Environ. Microbiol. , vol.74 , pp. 2004-2015
    • Kirscher, A.K.1    Schlesinger, J.2    Farnleitner, A.H.3    Hornek, R.4    Süß, B.5    Golda, B.6    Herzig, A.7    Reitner, B.8
  • 30
    • 29144469019 scopus 로고    scopus 로고
    • Territorial waters of the Baltic Sea as a source of infections caused by Vibrio cholerae non-O1, non-O139: Report of 3 hospitalized cases
    • Lukinmaa, S., K. Mattila, V. Lehtinen, M. Hakkinen, M. Koskela, and A. Siitonen. 2006. Territorial waters of the Baltic Sea as a source of infections caused by Vibrio cholerae non-O1, non-O139: report of 3 hospitalized cases. Diagn. Microbiol. Infect. Dis. 54:1-6.
    • (2006) Diagn. Microbiol. Infect. Dis. , vol.54 , pp. 1-6
    • Lukinmaa, S.1    Mattila, K.2    Lehtinen, V.3    Hakkinen, M.4    Koskela, M.5    Siitonen, A.6
  • 31
    • 0030071927 scopus 로고    scopus 로고
    • Physical linkage of the Vibrio cholerae mannose-sensitive hemagglutinin secretory and structural subunit gene loci: Identification of the mshG coding sequence
    • Marsh, J. W., D. Sun, and R. K. Taylor. 1996. Physical linkage of the Vibrio cholerae mannose-sensitive hemagglutinin secretory and structural subunit gene loci: identification of the mshG coding sequence. Infect. Immun. 64:460-465. (Pubitemid 26032814)
    • (1996) Infection and Immunity , vol.64 , Issue.2 , pp. 460-465
    • Marsh, J.W.1    Sun, D.2    Taylor, R.K.3
  • 34
    • 5144229755 scopus 로고    scopus 로고
    • Identification of a locus under complex positive selection in Drosophila simulans by haplotype mapping and composite-likelihood estimation
    • Meiklejohn, C. D., Y. Kim, D. L. Hartl, and J. Parsh. 2004. Identification of a locus under complex positive selection in Drosophila simulans by haplotype mapping and composite-likelihood estimation. Genetics 168:265-279.
    • (2004) Genetics , vol.168 , pp. 265-279
    • Meiklejohn, C.D.1    Kim, Y.2    Hartl, D.L.3    Parsh, J.4
  • 35
    • 34249869578 scopus 로고    scopus 로고
    • Detection and transformation of genome segments that differ within a coastal population of Vibrio cholerae strains
    • Miller, M. C., D. P. Keymer, A. Avelar, A. B. Boehm, and G. K. Schoolnik. 2007. Detection and transformation of genome segments that differ within a coastal population of Vibrio cholerae strains. Appl. Environ. Microbiol. 73:3695-3704.
    • (2007) Appl. Environ. Microbiol. , vol.73 , pp. 3695-3704
    • Miller, M.C.1    Keymer, D.P.2    Avelar, A.3    Boehm, A.B.4    Schoolnik, G.K.5
  • 36
    • 5444240735 scopus 로고    scopus 로고
    • Evolutionary genetic analysis of the emergence of epidemic Vibrio cholerae isolates on the basis of comparative nucleotide sequence analysis and multilocus virulence gene profiles
    • O'Shea, Y. A., F. J. Reen, A. M. Quirke, and E. F. Boyd. 2004. Evolutionary genetic analysis of the emergence of epidemic Vibrio cholerae isolates on the basis of comparative nucleotide sequence analysis and multilocus virulence gene profiles. J. Clin. Microbiol. 42:4657-44671.
    • (2004) J. Clin. Microbiol. , vol.42 , pp. 4657-44671
    • O'Shea, Y.A.1    Reen, F.J.2    Quirke, A.M.3    Boyd, E.F.4
  • 37
    • 0027522375 scopus 로고
    • CTX genetic element encodes a site-specific recombination system and an intestinal colonization factor
    • Pearson, G. D. N., A. Woods, S. L. Chiang, and J. J. Mekalanos. 1993. CTX genetic element encodes a site-specific recombination system and an intestinal colonization factor. Proc. Natl. Acad. Sci. USA 90:3750-3754.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3750-3754
    • Pearson, G.D.N.1    Woods, A.2    Chiang, S.L.3    Mekalanos, J.J.4
  • 38
    • 33644637994 scopus 로고    scopus 로고
    • Identification of a constitutively active variant of LuxO that affects production of HA/protease and biofilm development in a non-O1, non-O139 Vibrio cholerae O110
    • DOI 10.1016/j.gene.2005.10.031, PII S0378111905006906
    • Raychaudhuri, S., V. Jain, and M. Dongre. 2006. Identification of a constitutively active variant of LuxO that affects production of HA/protease and biofilm development in a non-O1, non-O139 Vibrio cholerae O110. Gene 369:126-133. (Pubitemid 43327339)
    • (2006) Gene , vol.369 , Issue.1-2 , pp. 126-133
    • Raychaudhuri, S.1    Jain, V.2    Dongre, M.3
  • 39
    • 0023950725 scopus 로고
    • Cholera toxin gene-positive Vibrio cholerae O1 Ogawa and Inaba strains produce the new cholera toxin
    • Saha, S., and S. C. Sanyal. 1988. Cholera toxin gene-positive Vibrio cholerae O1 Ogawa and Inaba strains produce the new cholera toxin. FEMS Microbiol. Lett. 50:113-116.
    • (1988) FEMS Microbiol. Lett. , vol.50 , pp. 113-116
    • Saha, S.1    Sanyal, S.C.2
  • 41
    • 0035146335 scopus 로고    scopus 로고
    • Molecular analysis of Vibrio cholerae O1, O139, non-O1, and non-O139 strains: Clonal relationships between clinical and environmental isolates
    • Singh, D. V., M. H. Matte, G. R. Matte, S. Jiang, F. Sabeena, B. N. Shukla, S. C. Sanyal, A. Huq, and R. R. Colwell. 2001. Molecular analysis of Vibrio cholerae O1, O139, non-O1, and non-O139 strains: clonal relationships between clinical and environmental isolates. Appl. Environ. Microbiol. 67:910-921.
    • (2001) Appl. Environ. Microbiol. , vol.67 , pp. 910-921
    • Singh, D.V.1    Matte, M.H.2    Matte, G.R.3    Jiang, S.4    Sabeena, F.5    Shukla, B.N.6    Sanyal, S.C.7    Huq, A.8    Colwell, R.R.9
  • 42
    • 0024313579 scopus 로고
    • Statistical method for testing the neutral mutation hypothesis by DNA polymorphism
    • Tajima, F. 1989. Statistical methods to test for nucleotide mutation hypothesis by DNA polymorphism. Genetics 123:585-595. (Pubitemid 19274682)
    • (1989) Genetics , vol.123 , Issue.3 , pp. 585-595
    • Tajima, F.1
  • 43
    • 33644778674 scopus 로고    scopus 로고
    • Directional positive selection on an allele of arbitrary dominance
    • DOI 10.1534/genetics.105.044065
    • Teshima, K. M., and M. Przeworski. 2006. Directional positive selection on an allele of arbitrary dominance. Genetics 172:713-718. (Pubitemid 43345528)
    • (2006) Genetics , vol.172 , Issue.1 , pp. 713-718
    • Teshima, K.M.1    Przeworski, M.2
  • 44
    • 0344464730 scopus 로고    scopus 로고
    • Libsequence: A C++ class library for evolutionary genetic analysis
    • DOI 10.1093/bioinformatics/btg316
    • Thornton, K. 2003. Application note libsequence: a C++ class library for evolutionary genetic analysis. Bioinformatics 19:2325-2327. (Pubitemid 37483994)
    • (2003) Bioinformatics , vol.19 , Issue.17 , pp. 2325-2327
    • Thornton, K.1
  • 45
    • 0036721177 scopus 로고    scopus 로고
    • Occurrence of antibiotic resistance gene cassettes aac(6′)-Ib, dfrA5, dfrA12, and ereA2 in class I integrons in non-O1, non-O139 Vibrio cholerae strains in India
    • Thungapathra, M., Amita, K. K. Sinha, S. R. Chaudhuri, P. Garg, T. Ramamurthy, G. B. Nair, and A. Ghosh. 2002. Occurrence of antibiotic resistance gene cassettes aac(6′)-Ib, dfrA5, dfrA12, and ereA2 in class I integrons in non-O1, non-O139 Vibrio cholerae strains in India. Antimicrob. Agents Chemother. 46:2948-2955.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 2948-2955
    • Thungapathra, M.1    Sinha, A.K.K.2    Chaudhuri, S.R.3    Garg, P.4    Ramamurthy, T.5    Nair, G.B.6    Ghosh, A.7
  • 46
    • 0029964829 scopus 로고    scopus 로고
    • Cloning and genetic analysis of the Vibrio cholerae aminopeptidase gene
    • Toma, C., and Y. Honma. 1996. Cloning and genetic analysis of the Vibrio cholerae aminopeptidase gene. Infect. Immun. 64:4495-4500.
    • (1996) Infect. Immun. , vol.64 , pp. 4495-4500
    • Toma, C.1    Honma, Y.2
  • 47
    • 0033573960 scopus 로고    scopus 로고
    • Cloning and characterization of a novel ompB operon from Vibrio cholerae 569B
    • Tow, L. A., and V. E. Coyne. 1999. Cloning and characterization of a novel ompB operon from Vibrio cholerae 569B. Biochim. Biophys. Acta 1444:269-275.
    • (1999) Biochim. Biophys. Acta , vol.1444 , pp. 269-275
    • Tow, L.A.1    Coyne, V.E.2
  • 48
    • 0031707437 scopus 로고    scopus 로고
    • Vibrio cholerae O1 strain TSI-4 produces the exopolysaccharide materials that determine colony morphology, stress resistance, and biofilm formation
    • Wai, S. N., Y. Mizunoe, A. Takade, S.-I. Kawabata, and S.-I. Yoshida. 1998. Vibrio cholerae O1 strain TSI-4 produces the exopolysaccharide materials that determine colony morphology, stress resistance, and biofilm formation. Appl. Environ. Microbiol. 64:3648-3655.
    • (1998) Appl. Environ. Microbiol. , vol.64 , pp. 3648-3655
    • Wai, S.N.1    Mizunoe, Y.2    Takade, A.3    Kawabata, S.-I.4    Yoshida, S.-I.5
  • 49
    • 0028039053 scopus 로고
    • ToxR regulates virulence gene expression in non-O1 strains of Vibrio cholerae that cause epidemic cholera
    • Waldor, M. K., and J. J. Mekalanos. 1994. ToxR regulates virulence gene expression in non-O1 strains of Vibrio cholerae that cause epidemic cholera. Infect. Immun. 62:72-78.
    • (1994) Infect. Immun. , vol.62 , pp. 72-78
    • Waldor, M.K.1    Mekalanos, J.J.2
  • 50
    • 0016491430 scopus 로고
    • On the number of segregation sites
    • Watterson, G. 1975. On the number of segregation sites. Theor. Popul. Biol. 7:256-276.
    • (1975) Theor. Popul. Biol. , vol.7 , pp. 256-276
    • Watterson, G.1
  • 51
    • 0031897964 scopus 로고    scopus 로고
    • Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution
    • Yang, Z. 1998. Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. Mol. Biol. Evol. 15:568-573.
    • (1998) Mol. Biol. Evol. , vol.15 , pp. 568-573
    • Yang, Z.1
  • 52
    • 0031906352 scopus 로고    scopus 로고
    • Role of rpoS in stress survival and virulence of Vibrio cholerae
    • Yildiz, F. H., and G. K. Schoolnik. 1998. Role of rpoS in stress survival and virulence of Vibrio cholerae. J. Bacteriol. 180:773-784.
    • (1998) J. Bacteriol. , vol.180 , pp. 773-784
    • Yildiz, F.H.1    Schoolnik, G.K.2
  • 54
    • 0141989893 scopus 로고    scopus 로고
    • Quorum sensing-dependent biofilms enhance colonization in Vibrio cholerae
    • Zhu, J., and J. J. Mekalanos. 2003. Quorum sensing-dependent biofilms enhance colonization in Vibrio cholerae. Dev. Cell 5:647-656.
    • (2003) Dev. Cell , vol.5 , pp. 647-656
    • Zhu, J.1    Mekalanos, J.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.