Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields

Cardiovascular Research

Volumn 82, Issue 3, 2009, Pages 411-420

  Gaetani, Roberto ^a   Ledda, Mario ^b   Barile, Lucio ^a   Chimenti, Isotta ^a   De Carlo, Flavia ^b   Forte, Elvira ^a   Ionta, Vittoria ^a   Giuliani, Livio ^c   D'Emilia, Enrico ^c   Frati, Giacomo ^a,d   Miraldi, Fabio ^a   Pozzi, Deleana ^a   Messina, Elisa ^a   Grimaldi, Settimio ^b   Giacomello, Alessandro ^a   Lisi, Antonella ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CNR   (Italy)

^c ISPESL   (Italy)

^d IRCCS NEUROMED   (Italy)

Author keywords

Ca2+ ion cyclotron resonance; Cardiac regenerative medicine; Clinical translation protocols; ELF EMF

Indexed keywords

CALCIUM; CALCIUM ION;

ADULT; AGED; AMINO ACID SEQUENCE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROMAGNETIC FIELD; FEMALE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MALE; PHENOTYPE; PRIORITY JOURNAL; STEM CELL;

ADULT STEM CELLS; CALCIUM; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; ELECTROMAGNETIC FIELDS; HUMANS; MYOCARDIUM;

EID: 66249112518     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp067     Document Type: Article

References (34)

1. Abraham MR, Henrikson CA, Tung L, Chang MG, Aon M, Xue T et al. Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation.Circ Res 2005;97:159-167.
2. Cho HJ, Lee N, Lee JY, Choi YJ, Ii M, Wecker A et al. Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart. J Exp Med 2007;204:3257- 3269.
3. Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003;114:763-776.
4. Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S et al. Postnatal isl1p cardioblasts enter fully differentiated cardiomyocyte lineages. Nature 2005;433:647-653.
5. Messina E, De Angelis L, Frati G, Morrone S, Chimenti S, Fiordaliso F et al. Isolation and expansion of adult cardiac stem cells from human and murine heart.Circ Res 2004;95:911-921.
6. Oh H, Bradfute SB, Gallardo TD, Nakamura T, Gaussin V, Mishina Y et al. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci USA 2003;100: 12313-12318.
7. Ott HC, Matthiesen TS, Brechtken J, Grindle S, Goh SK, Nelson W et al. The adult human heart as a source for stem cells: repair strategies with embryonic-like progenitor cells. Nat Clin Pract Cardiovasc Med 2007;4(Suppl. 1):S27-S39.
8. van Vliet P, Roccio M, Smits AM, van Oorschot AA, Metz CH, van Veen TA et al. Progenitor cells isolated from the human heart: a potential cell source for regenerative therapy. Neth Heart J 2008;16:163-169.
9. Oyama T, Nagai T, Wada H, Naito AT, Matsuura K, Iwanaga K et al. Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. J Cell Biol 2007;176:329-341.
10. Smith RR, Barile L, Cho HC, Leppo MK, Hare JM, Messina E et al. Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens.Circulation 2007;115:896-908.
11. Cossarizza A, Monti D, Bersani F, Scarfi MR, Zanotti M, Cadossi R et al. Exposure to low-frequency pulsed electromagnetic fields increases mitogen-induced lymphocyte proliferation in Down's syndrome. Aging (Milano) 1991;3:241-246.
12. Cossarizza A, Monti D, Bersani F, Cantini M, Cadossi R, Sacchi A et al. Extremely low frequency pulsed electromagnetic fields increase cell proliferation in lymphocytes from young and aged subjects. Biochem Biophys Res Commun 1989;160:692-698.
13. Cadossi R, Bersani F, Cossarizza A, Zucchini P, Emilia G, Torelli G et al. Lymphocytes and low-frequency electromagnetic fields. FASEB J 1992;6:2667-2674.
14. Cossarizza A, Angioni S, Petraglia F, Genazzani AR, Monti D, Capri M et al. Exposure to low frequency pulsed electromagnetic fields increases interleukin-1 and interleukin-6 production by human peripheral blood mononuclear cells. Exp Cell Res 1993;204:385-387.
15. Lisi A, Ciotti MT, Ledda M, Pieri M, Zona C, Mercanti D et al. Exposure to 50 Hz electromagnetic radiation promote early maturation and differentiation in newborn rat cerebellar granule neurons. J Cell Physiol 2005;204:532-538.
16. Lisi A, Ledda M, Rosola E, Pozzi D, D'Emilia E, Giuliani L et al. Extremely low frequency electromagnetic field exposure promotes differentiation of pituitary corticotrope-derived AtT20 D16V cells. Bioelectromagnetics 2006;27:641-651.
17. Thomas AW, Kavaliers M, Prato FS, Ossenkopp KP. Pulsed magnetic field induced 'analgesia' in the land snail, Cepaea nemoralis, and the effects of mu, delta, and kappa opioid receptor agonists/antagonists. Peptides 1997;18:703-709.
18. Vorobyov VV, Sosunov EA, Kukushkin NI, Lednev VV. Weak combined magnetic field affects basic and morphine-induced rat's EEG. Brain Res 1998;781:182-187.
19. Ibiwoye MO, Powell KA, Grabiner MD, Patterson TE, Sakai Y, Zborowski M et al. Bone mass is preserved in a critical-sized osteotomy by low energy pulsed electromagnetic fields as quantitated by in vivo micro-computed tomography. J Orthop Res 2004;22:1086-1093.
20. Albertini A, Zucchini P, Noera G, Cadossi R, Napoleone CP, Pierangeli A. Protective effect of low frequency low energy pulsing electromagnetic fields on acute experimental myocardial infarcts in rats. Bioelectromag-netics 1999;20:372-377.
21. Ventura C, Maioli M, Asara Y, Santoni D, Mesirca P, Remondini D et al. Turning on stem cell cardiogenesis with extremely low frequency magnetic fields. FASEB J 2005;19:155-157.
22. Lisi A, Ledda M, de Carlo F, Pozzi D, Messina E, Gaetani R et al. Ion cyclotron resonance as a tool in regenerative medicine. Electromagn Biol Med 2008;27:127-133.
23. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001;25:402-408.
24. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685.
25. Lednev VV. Possible mechanism for the influence of weak magnetic fields on biological systems. Bioelectromagnetics 1991;12:71-75.
26. Liboff AR. Electric-field ion cyclotron resonance. Bioelectromagnetics 1997;18:85-87.
27. 2+ signalling in development and maturation of mammalian cerebellar granule cells. J Physiol 2006;575:389-395.
28. Cai H, Liu D, Garcia JG. CaM kinase II-dependent pathophysiological signalling in endothelial cells. Cardiovasc Res 2008;77:30-34.
29. Means AR. Calcium, calmodulin and cell cycle regulation. FEBS Lett 1994;347:1-4.
30. Takuwa N, Zhou W, Takuwa Y. Calcium, calmodulin and cell cycle progression. Cell Signal 1995;7:93-104.
31. Whitfield JF, Boynton AL, MacManus JP, Sikorska M, Tsang BK. The regulation of cell proliferation by calcium and cyclic AMP. Mol Cell Biochem 1979;27:155-179.
32. Manni V, Lisi A, Pozzi D, Rieti S, Serafino A, Giuliani L et al. Effects of extremely low frequency (50 Hz) magnetic field on morphological and biochemical properties of human keratinocytes. Bioelectromagnetics 2002;23:298-305.
33. Walleczek J, Budinger TF. Pulsed magnetic field effects on calcium signaling in lymphocytes: dependence on cell status and field intensity. FEBS Lett 1992;314:351-355.
34. Manni V, Lisi A, Rieti S, Serafino A, Ledda M, Giuliani L et al. Low electromagnetic field (50 Hz) induces differentiation on primary human oral keratinocytes (HOK). Bioelectromagnetics 2004;25:118-126.