Accidental methadone ingestion in an infant: Case report and review of the literature

Pediatric Emergency Care

Volumn 25, Issue 2, 2009, Pages 109-111

  Glatstein, Miguel ^a   Finkelstein, Yaron ^a   Scolnik, Dennis ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b NONE   (Canada)

Author keywords

Methadone; Poisoning; Unintentional methadone poisoning; Unintentional narcotic poisoning

Indexed keywords

ANTIBIOTIC AGENT; DRUG METABOLITE; METHADONE; MORPHINE; NALOXONE;

ARTICLE; BACTERIAL INFECTION; CARBON DIOXIDE TENSION; CASE REPORT; CHILD BEHAVIOR; DRUG INTOXICATION; FEMALE; FOLLOW UP; GRANDPARENT; HOSPITAL DISCHARGE; HUMAN; INFANT; INGESTION; LETHARGY; MORPHINE ADDICTION; RESPIRATORY ACIDOSIS; SEPSIS; SOCIAL WORK; VITAL SIGN;

FEMALE; HUMANS; INFANT; METHADONE; NALOXONE; NARCOTIC ANTAGONISTS; NARCOTICS;

EID: 66249101645     PISSN: 07495161     EISSN: None     Source Type: Journal    
DOI: 10.1097/PEC.0b013e318196faff     Document Type: Article

References (34)

1. Dawe S, Harnett P. Reducing potential for child abuse among methadone-maintained parents: results from a randomized controlled trial. J Subst Abuse Treat. 2007;32:381-390.
2. Klupp N, Risser D, Stichenwirth M, et al. Fatal methadone poisoning of a child. Wien Klin Wochenschr. 2000;1 12:365-367.
3. Neeleman J, Farrel M. Fatal methadone and heroin overdoses: time trends in England and Wales. J Epidemiol Community Health. 1997;51:435-437.
4. Watson WA, Litovitz TL, Rodgers GC, et al. 2004 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med. 2005;23(5):589-666.
5. Nisse P, Cezard C, Peucelle D, et al. Accidental ingestion of methadone and buprenorphine by children. A case review of the Lille Poison Centre between 1995 and 2005 [In French]. Acta Clin Belg Suppl. 2006; 1:37-40.
6. Binchy JM, Molynewux EM, Manning J. Accidental ingestion of methadone by children in Merseyside. BMJ. 1994;308:1335-1336.
7. Couper FJ, Chopra K, Pierre-Louis MLY. Fatal methadone intoxication in an infant. Forensic Sci Int. 2005;153:71-73.
8. Li L, Levine B, Smialek JE. Fatal methadone poisoning in children: Maryland 1992-1996. Subst Use Misuse. 2000;35:1141-1148.
9. Lalkin A, Kapur BM, Verjee ZH, et al. Contamination of antibiotics resulting in severe pediatric methadone poisoning. Ann Phamacother. 1999;33:1011.
10. Riascos R, Kumfa P, Rojas R, et al. Fatal methadone intoxication in a child. Emerg Radiol. 2008;15:67-70.
11. Leblanc A, Benbrick N, Moreau Mh. Methadone poisoning in a 1-year-old child treated by continuous infusion of naloxone. Arch Pediatr. 2002;9:694-696.
12. Anselmo M, Campos Rainho A, do Carmo Vale M, et al. Methadone intoxication in a child: toxic encephalopathy. J Child Neurol. 2006;21:618-620.
13. Hainer C, Bernhard M, Gries A. Preclinical management of accidental methadone intoxication of a 4-year-old girl. Antagonist of intubation. Anaesthesist. 2004;53:955-958.
14. Tiras S, Haas V, Chevret L, et al. Nonketotic hyperglycemic coma in toddlers after unintentional methadone ingestion. Ann Emerg Med. 2006;48:448-451.
15. González Castro CA, Martin Egana M, Suberviola Canas B, et al. Pediatric methadone poisoning. An Pediatr (Barc). 2007;66:327-328.
16. Gourlay GK, Coulthard K. The role of naloxone infusions in the treatment of overdoses of long half-life narcotic agonists: application to nor-methadone. Br J Clin Pharmacol. 1983;15:269-271.
17. Schwab J, Caggiano A. Pediatric methadone poisoning revisited. Clin Pediatr. 2001;40:1 19-120.
18. Smialek JE, Monteforte JR, Aronow R, et al. Methadone deaths in childhood. JAMA. 1977;238:2516-2517.
19. Luke Y, Megarbane B, Borron SW Opioids. In: Shannon M, ed. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose. 4th ed. Philadelphia, PA: Saunders; 2007:635-658.
20. Milroy CM, Forrest ARW Methadone deaths: a toxicological analysis. J Clin Pathol. 2000;53:277-281.
21. Bloor RN, McAuley R, Smalldridge N. Safe storage of methadone in the home-an audit of the effectiveness of safety information giving. Harm Reduct J. 2005;2:9.
22. Kintz P, Villain M, Dumestre-Toulet V, et al. Methadone as a chemical weapon: two fatal cases involving babies. Ther Drug Monit. 2006; 28:712-713.
23. Winstock AR, Lea T. Safe storage of methadone takeaway dosesVa survey of patient practice. Aust N Z J Public Health. 2007;31:526-528.
24. Nadelmann E, McNeeley J, Ducker E. International perspectives. In: Lowinson JH, Ruiz P, Millman RB, et al, eds. Substance Abuse. A Comprehensive Textbook. 3rd ed. London, England: Lippincott Williams & Wilkins; 1997:22-39.
25. Kreek MK, Reisenger M. The addict as a patient. In: Lowinson JH, Ruiz P, Millman RB, et al, eds. Substance Abuse. A Comprehensive Textbook. 3rd ed. London, England: Lippincott Williams & Wilkins; 1997: 822-853.
26. Litovitz T, Magogurerra A. Comparison of pediatric poisoning hazards: an analysis of 3.8 million exposures incidents. A report for the American Association of Poison Control Centers. Pediatrics. 1992;89:999-1006.
27. Loimer N, Schmidt R. The use of plasma level to optimize maintenance treatment. Drug Alcohol Depend. 1992;20:241.
28. Robinson AE, Williams FM. The distribution of methadone in man. J Pharm Pharmacol. 1971;23:353-358.
29. Wilkerson R, Northington L, Fisher W Ingestion of toxic substances by infants and children. What we don't know can hurt. Crit Care Nurse. 2005;25:35-44.
30. Totah RA, Sheffels P, Roberts T, et al. Role of CYP2B6 in stereoselective human methadone metabolism. Anesthesiology. 2008;108:351-352.
31. Dart RC. Methadone. In: Dart RC, ed. Medical Toxicology. 3rd ed. Philadelphia, PA: Lippincott William & Wilkins; 2004:767-768.
32. Feldberg W, Pyke D, Stubbs WA. Hyperglycaemia: imitating Claude Bernard's piqure with drugs. J Auton Nerv Syst. 1985;14:213-228.
33. Ford M, Hoffman RS, Goldfrank LR. Opioid and designer drugs. Emerg Med Clin North Am. 1990;8:495-512.
34. Kleinschmidt KC, Wainscott M, Ford MD. Opioids. In: Ford M, Delaney K, Ling L, Erickson T, eds. Clinical Toxicology. Saunders: Philadelphia, PA; 2001:627-639.