Contamination of antibiotics resulting in severe pediatric methadone poisoning

Annals of Pharmacotherapy

Volumn 33, Issue 3, 1999, Pages 314-317

  Lalkin, Arieh ^a   Kapur, Bhushan M ^b   Koren, Gideon ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Amoxicillin; Contamination; Methadone

Indexed keywords

AMOXICILLIN; ANTIBIOTIC AGENT; METHADONE;

ANTIBIOTIC THERAPY; ARTICLE; CASE REPORT; CHILD; CONTAMINATION; COUGHING; DISEASE SEVERITY; DRUG INTOXICATION; FEVER; HUMAN; MALE; PRIORITY JOURNAL; SUSPENSION; UNCONSCIOUSNESS;

AMOXICILLIN; CANADA; CHILD, PRESCHOOL; DRUG CONTAMINATION; HUMANS; MALE; METHADONE; NARCOTICS; PENICILLINS; PHARMACY; POISONING; SUSPENSIONS;

EID: 0032930204     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.18132     Document Type: Article

References (20)

1. Ling W, Wesson DR. Drugs of abuse - opiates. West J Med 1990;152: 565-72.
2. Farrell M, Ward J, Mattick R, Hall W, Stimson G, des Jarlais D, et al. Methadone maintenance treatment in opiate dependence: a review. BMJ 1994;309:997-1001.
3. Aronov R, Paul SD, Woolley PV Jr. Childhood poisoning. An unfortunate consequence of methadone availability. JAMA 1972;219:321-4.
4. Aronov R, Brenner SL, Woolley PV Jr. An apparent epidemic: methadone poisoning in children. Clinical Toxicol 1973;6:175-81.
5. Smialek JE, Monforte JR, Aronov R, Spitz WU. Methadone deaths in children. A continuing problem. JAMA 1977;238:2516-7.
6. Binchy JM, Molyneux EM, Manning J. Accidental ingestion of methadone by children in Merseyside. BMJ 1994;308:1335-6.
7. Baselt RC, Cravey RH. Methadone in disposition of toxic drugs and chemicals in man. 4th ed. Foster City, CA: Chemical Toxicology Institute, 1995:472-5.
8. Dole VJ. Interim methadone clinics: an undervalued approach. Am J Public Health 1991;81:1111-2.
9. Newman RG. Methadone treatment: defining and evaluating success. N Engl J Med 1987;317:447-50.
10. Grabinski PY, Kaiko RF, Rogers AG, Houde RW. Plasma levels and analgesia following deltoid and gluteal injections of methadone and morphine. J Clin Pharm 1983;23:48-55.
11. Inturrisi CE, Verebely K. Disposition of methadone in man after a single oral dose. Clin Pharmacol Ther 1972c;13:923-30.
12. Goldfrank LR, Weisman RS. Opioids. In: Goldfrank LR. ed. Goldfrank's toxicologic emergencies. 5th ed. Stamford, CT: Appleton & Lange, 1994:769-83.
13. Olsen GD, Wendel HA, Livermore JD, Leger RM, Lynn RK, Gerber N. Clinical effects and pharmacokinetics of racemic methadone and its isomers. Clin Pharmacol Ther 1977;21:147-59.
14. Hendra TJ, Gerrish SP, Forrest ARW. Fatal methadone poisoning. BMJ 1996;313:481-2.
15. Harding-Pink D. Les décès associès a la méthadone. J Toxicol Clin Exp 1991;11:31-49.
16. Blatman S. Narcotic poisoning of children (I) through accidental ingestion of methadone and (II) in utero. Pediatrics 1974;54:329-32.
17. Roland EH, Lockitch G, Dunn HG, Peacock D, Pirie GE. Methadone poisoning due to accidental contamination of prescribed medication. Can Med Assoc J 1984;131:1357-8.
18. Gayle MO, Ryan CA, Nazarali S. Unusual cause of methadone poisoning. Acta Paediatr 1991;80:486-7.
19. Discipline committee dismisses charges. Coll Pharm B C Bull 1984;9:3-4.
20. Moore PA, Rumack BH, Conner CS, Peterson RG. Naloxone underdosage after narcotic poisoning. Am J Dis Child 1981;134:156-8.