Study on the anti-seizure activity of methanolic extracts of Indigofera Tinctoria (L.)

Pharmacologyonline

Volumn 1, Issue , 2009, Pages 1341-1351

  Saravana Kumar, A ^a   Madhan Mohan, E ^b   Gandhimathi, R ^a   Amudha, P ^b  

^a Prince Dr K Vasudevan College of Engineering and Technology   (India)

^b C L BAID METHA COLLEGE OF PHARMACY   (India)

Author keywords

Antiseizure activity; Indigofera tinctoria; Maximal Electroshock; Pentylenetetrazole; Traditional Medicine

Indexed keywords

4 AMINOBUTYRIC ACID; BENZODIAZEPINE RECEPTOR; CHLORIDE CHANNEL; DIAZEPAM; INDIGOFERA TINCTORIA EXTRACT; METHANOL; PENTETRAZOLE; PHENYTOIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CLONIC SEIZURE; CONTROLLED STUDY; DISEASE DURATION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG SCREENING; ELECTRIC SHOCK; HINDLIMB; INDIGOFERA; INDIGOFERA TINCTORIA; NONHUMAN; PLANT LEAF; RAT; RECOMMENDED DRUG DOSE; SOXHLET EXTRACTION; STUPOR; WISTAR RAT;

EID: 66249096020     PISSN: None     EISSN: 18278620     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Rapp PR., Bachevalier J. Cognitive development and aging. In: Squire, L.R., Bloom, F.E., McConnell, S.K., Roberts, J.L., Spitzer, N.C., Zigmond, M.J. (Eds.), Fundamental Neuroscience, 2nd ed. Academic Press, USA, 2003:1167-1199.
2. Gupta YK, Malhotra. J. Indian J. Physiol. Pharmacol. 2000: 44; 8.
3. Raza M, Shaheen F, Choudhary MI, Sombati S, Rafiq A, Suria, A, Rahman AU, De Lorenzo RJ. Anticonvulsant activities of ethanolic extract and aqueous fraction isolated from Delphinium denudatum. J. Ethnopharmacol. 2001: 78; 73-78.
4. Dichter MA. Basic mechanisms of epilepsy: targets for therapeutic intervention. Epilepsia. 1997: 38 (9); S2-S6.
5. Löscher W. New visions in the pharmacology of anticonvulsion. Eur. J. Pharmacol. 1998: 342; 1-13.
6. Meldrum B. Identification and preclinical testing of novel antiepileptic compounds. Epilepsia 1997: 38 (Suppl. 9); S7-S15.
7. Indigofera tinctoria (L.). http://en.wikipedia.org/wiki/ Indigofera_tinctoria
8. Nadkarni AK. Indian Materia Medica 1926; 1: 680-682.
9. Chopra RN, Nayer SL, Chopra IC. Glossary of Indian Medicinal Plants, National Institute of Science Communication 1996: 141.
10. Singh B, Saxena AK, Chandan BK, Bhardwaj V, Gupta VN, Suri OP and Handa SS. Hepatoprotective Activity of Indigtone-A Bioactive fraction from Indigofera tinctoria Linn. Phytotherapy Reserch 2001; 15: 294-297.
11. Narender T, Tanvir K, Anjupuri and Ramesh Chander. Antidyslipidemic activity of furano-flavonoids isolated from Indigofera tinctoria. Bioorganic & Medicinal Chemistry Letters 2006; 16: 3411-3414.
12. Kameswaran R and Ramanibai R. The Antiproliferative Activity of Flavanoidal Fraction of Indigofera tinctoria is Through Cell Cycle Arrest and Apoptotic Pathway in A-549 Cells. Journal of Biological Sciences 2008: 1-7.
13. Hoessel R, Eisenbrand G and Meijer L. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nature cell biology 1999; 1: 60-67.
14. Cragg GM and Newman. Plants as a Source of Anti-Cancer Agents. Developed under the Auspices of the UNESCO, Encyclopedia of Life Support System (EOLLS), Oxford, UK 2006.
15. Harbone JP, Phytochemical methods, a guide to modern technique of plant analysis (Chapmann and Hall, London). 1973;1-271.
16. OECD, 2002. Acute oral toxicity. Acute oral toxic class method guideline 423 adopted 23.03.1996. In: Eleventh Addendum to the, OECD, guidelines for the testing of chemicals organisation for economical co-operation and development, Paris, June, 2000.
17. Balakrishnan S, Pandhi P, Bhargava VK. Effects of Nimodipine on the efficacy of commonly used anti-epileptic drugs in rats. Ind J Exp Biol. 1998; 36:51-54.
18. Kulkarni SK and George B. Significance of long term potentiation in cognitive functions and epilepsy. Ind J Pharmacol. 1999; 31:14-22.
19. Loscher W. and Schmidt D. Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res. 1988; 2: 145-181.
20. Oliveira FA, Almeida RN, Sousa MFV, Barbosa-Filho JM, Diniz SA, Medeiros IA. Anticonvulsant properties of N-salicyloyltryptamine in mice. Pharmacol Biochem Behav. 2001; 68: 199-202.
21. Quintans-Júnior LJ, Almeida RN, Falcão ACGM, Agra MF, Sousa MFV, Barbosa-Filho JM. Avaliação da Atividade anticonvulsivante de plantas do Nordeste Brasileiro. Acta Farm Bonaerense. 2002; 21: 179-184.
22. Kupferberg HJ. Antiepileptic drug development program: a cooperative effort of government and industry. Epilepsia. 1989; 30(Suppl 1):S51-S56.
23. Stables JP, Kupferberg HJ. The NIH Anticonvulsant Drug Development (ADD) Program: Preclinical Anticonvulsant Screening project. In: Antiepileptic Drugs, 4th edn. Ed. Levy RH, Mattson RH, Meldrum BS, Raven Press, New York. 1995; 4-17.
24. White H S. Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs. Epilepsia.1997; 38 (Suppl. 1): 9.
25. McDonald RL, Kelly KM. Antiepileptic drugs: Mechanisms of action. Epilepsia. 1993; 34:S1-S8.
26. Almeida RN, Navarro DS, Assis TA, Medeiros A, Thomas G. Antidepressant effect of an ethanolic extract of the leaves of Cissampelos sympodialis in rats and mice. J Ethnopharmacol. 1998; 63: 247-252.
27. Ngo Bum E, Schmutz M, Meyer C, Rakotonirina A, Bopelet M, Portet C, Jeker A, Rakotonirina SV, Olpe HR and Herrling P. Anticonvulsant properties of the methanolic extract of Cyperus articulatus (Cyperaceae). J Ethnopharmacol. 2001; 76: 145-150.
28. De Deyn PP, D'Hooge R, Marescau B and Pei YQ. Chemical model of epilepsy with some reference to their applicability in the development of anticonvulsant. Epilepsy Res. 1992; 12: 87-110.
29. Coulter DA, Hugenard JR and Prince DA. Characterization of the ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann. Neurol. 1989; 25: 582-593.
30. Rogawski MA and Porter RJ. Antiepileptic drugs and pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol Rev. 1995; 42: 223-286.
31. Macdonald RL and Kelly KM. Antiepileptic drug mechanisms of action. Epilapsia. 1995; 36: S2-S12.