Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors

Journal of Medicinal Chemistry

Volumn 52, Issue 10, 2009, Pages 3142-3145

  Takahashi, Toshiyuki ^a   Nagase, Tsuyoshi ^a   Sasaki, Takahide ^a   Nagumo, Akira ^a   Shimamura, Ken ^a   Miyamoto, Yasuhisa ^a   Kitazawa, Hidefumi ^a   Kanesaka, Maki ^a   Yoshimoto, Ryo ^a   Aragane, Katsumi ^a   Tokita, Shigeru ^a   Sato, Nagaaki ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; INDOLE DERIVATIVE; LONG CHAIN FATTY ACID ELONGASE 6 INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG IDENTIFICATION; DRUG PENETRATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; LIVER; MALE; MOUSE; NONHUMAN; REACTION OPTIMIZATION;

ACETYLTRANSFERASES; ADMINISTRATION, ORAL; ANIMALS; DRUG STABILITY; ENZYME INHIBITORS; INDOLES; LIVER; MICE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 66249093783     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900391x     Document Type: Article

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