In vitro formation of phase I and II metabolites of propranolol and determination of their structures using chemical derivatization and liquid chromatography-tandem mass spectrometry

Journal of Mass Spectrometry

Volumn 44, Issue 5, 2009, Pages 742-754

  Salomonsson, Matilda Lampinen ^a,b   Bondesson, Ulf ^a,b   Hedeland, Mikael ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b NATIONAL VETERINARY INSTITUTE   (Sweden)

Author keywords

1,2 dimethylimidazole 4 sulfonyl chloride (DMISC); Derivatization; Glucuronides; LC MS MS; Propranolol; Structural investigation

Indexed keywords

AMINES; AROMATIC COMPOUNDS; AROMATIZATION; CHLORINE COMPOUNDS; ELECTROSPRAY IONIZATION; GLUCOSE; ISOMERS; MASS SPECTROMETRY; METABOLITES;

1,2-DIMETHYLIMIDAZOLE-4-SULFONYL CHLORIDE (DMISC); DERIVATIZATIONS; GLUCURONIDES; LC-MS/MS; PROPRANOLOL; STRUCTURAL INVESTIGATION;

LIQUID CHROMATOGRAPHY;

1,2 DIMETHYLIMIDAZOLE 4 SULFONYL CHLORIDE; 4 HYDROXYPROPANOLOL GLUCURONIDE; AGLYCONE; ALIPHATIC COMPOUND; AMINE; AROMATIC COMPOUND; GLUCURONIC ACID; PROPRANOLOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; COMPARATIVE STUDY; DERIVATIZATION; ELECTROSPRAY; FRAGMENTATION REACTION; HYDROXYLATION; IN VITRO STUDY; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; METABOLITE; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

EID: 66249083499     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1551     Document Type: Article

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