The enzymatic glucuronidation of 3-O-protected morphine - A new route to 7,8-dihydromorphine-6-glucuronide

Tetrahedron Asymmetry

Volumn 11, Issue 2, 2000, Pages 413-416

  Jenkins, Gareth N ^a   Stachulski, Andrew V ^a   Scheinmann, Feodor ^a   Turner, Nicholas J ^b  

^a Synergy House   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; GLUCURONIDE; MORPHINE; MORPHINE DERIVATIVE;

DRUG GLUCURONIDATION; DRUG STRUCTURE; DRUG SYNTHESIS; GLUCURONIDATION; HUMAN; HUMAN TISSUE; LIVER MICROSOME; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0034635626     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(99)00582-0     Document Type: Article

References (11)

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2. Brown, R. T.; Carter, N. E.; Scheinmann, F.; Turner, N. J. Tetrahedron Lett. 1995, 36, 1117; EP 0733120.
3. Burchell, B. Rev. Biochem. Toxic. 1981, 3, 1; Irshaid, Y. M.; Tephly, T. R. Mol. Pharmacol. 1987, 31, 27.
4. Burchell, B. Rev. Biochem. Toxic. 1981, 3, 1; Irshaid, Y. M.; Tephly, T. R. Mol. Pharmacol. 1987, 31, 27.
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8. Scheinmann, F.; Lumbard, K. W.; Brown, R. T.; Mayalarp, S. P. International Patent, 1993, WO 93/3051; Brown, R. T.; Mayalarp, S. P.; McGown, A. T.; Hadfield, J. A. J. Chem. Res. 1993, 496.
9. Lacy, C.; Sainsbury, M. Tetrahedron Lett. 1995, 36, 3949; Berrang, B.; Brine, G. A.; Carroll, F. I. Synthesis 1997, 1165.
10. Lacy, C.; Sainsbury, M. Tetrahedron Lett. 1995, 36, 3949; Berrang, B.; Brine, G. A.; Carroll, F. I. Synthesis 1997, 1165.
11. Joel, S. P.; Scheinmann, F.; Stachulski, A. V. PCT 1998, GB 98/01071.