IL-12 stimulates the osteoclast inhibitory peptide-1 (OIP-1/hSca) gene expression in CD4+ T cells

Journal of Cellular Biochemistry

Volumn 107, Issue 1, 2009, Pages 104-111

  Shanmugarajan, Srinivasan ^a   Kawanabe, Noriaki ^b   Koide, Masanori ^c   Tsuruga, Eichi ^a   Arroyo, Jazmine E ^a   Key Jr , Lyndon L ^a   Reddy, Sakamuri V ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b OKAYAMA UNIVERSITY   (Japan)

^c MATSUMOTO DENTAL UNIVERSITY   (Japan)

Author keywords

Bone marrow cells; Interferon ; Osteoclast inhibitory peptide 1; STAT; T cells

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON ANTIBODY; INTERLEUKIN 12; MESSENGER RNA; NEUTRALIZING ANTIBODY; STAT1 PROTEIN; STAT3 PROTEIN;

ARTICLE; BONE MARROW CELL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE; GENE ACTIVITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOREGULATION; IMMUNOSTIMULATION; MONONUCLEAR CELL; OSTEOCLAST INHIBITORY PEPTIDE 1 GENE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; REPORTER GENE; T LYMPHOCYTE ACTIVATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CD4-POSITIVE T-LYMPHOCYTES; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-12; JURKAT CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS;

EID: 66149185550     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22104     Document Type: Article

References (25)

1. Abu-Amer Y. 2001. IL-4 abrogates osteoclastogenesis through STAT6- dependent inhibition of NF-kappaB. J Clin Invest 107:1375-1385.
2. Bonyadi M, Waldman SD, Liu D, Aubin JE, Grynpas MD, Stanford WL. 2003. Mesenchymal progenitor self-renewal deficiency leads to age-dependent osteoporosis in Sca-1/Ly-6A null mice. Proc Natl Acad Sci USA 100:5840-5845.
3. Bright JJ, Sriram S. 1998. TGF-beta inhibits IL-12-induced activation of Jak- STAT pathway in T lymphocytes. J Immunol 161:1772-1777.
4. Choi Y, Woo KM, Ko SH, Lee YJ, Park SJ, Kim HM, Kwon BS. 2001. Osteoclastogenesis is enhanced by activated B cells but suppressed by activated CD8(+) T cells. Eur J Immunol 31:2179-2188.
5. Classon BJ, Coverdale L. 1996. Genomic organization and expression of mouse thymic shared antigen-1 (TSA-1): Evidence for a processed pseudogene. Immunogenetics 44:222-226.
6. Gerosa F, Paganin C, Peritt D, Paiola F, Scupoli MT, Aste-Amezaga M, Frank I, Trinchieri G. 1996. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10. J Exp Med 183:2559-2569.
7. Grcevic D, Katavic V, Lukic IK, Kovacic N, Lorenzo JA, Marusic A. 2001. Cellular and molecular interactions between immune system and bone. Croat Med J 42:384-392.
8. Horwood NJ, Elliott J, Martin TJ, Gillespie MT. 2001. IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro. J Immunol 166:4915-4921.
9. Ikeda F, Nishimura R, Matsubara T, Tanaka S, Inoue J, Reddy SV, Hata K, Yamashita K, Hiraga T, Watanabe T, Kukita T, Yoshioka K, Rao A, Yoneda T. 2004. Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest 114:475-484.
10. John V, Hock JM, Short LL, Glasebrook AL, Galvin RJ. 1996. A role for CD8+ T lymphocytes in osteoclast differentiation in vitro. Endocrinology 137: 2457-2463.
11. Kitaura H, Nagata N, Fujimura Y, Hotokezaka H, Yoshida N, Nakayama K. 2002. Effect of IL-12 on TNF-alpha-mediated osteoclast formation in bone marrow cells: Apoptosis mediated by Fas/Fas ligand interaction. J Immunol 169:4732-4738.
12. Koide M, Kurihara N, Maeda H, Reddy SV. 2002. Identification of the functional domain of osteoclast inhibitory peptide-1/hSca. J Bone Miner Res 17:111-118.
13. Koide M, Maeda H, Roccisana JL, Kawanabe N, Reddy SV. 2003. Cytokine regulation and the signaling mechanism of osteoclast inhibitory peptide-1 (OIP-1/hSca) to inhibit osteoclast formation. J Bone Miner Res 18:458-465.
14. Kosugi A, Saitoh S, Noda S, Miyake K, Yamashita Y, Kimoto M, Ogata M, Hamaoka T. 1998. Physical and functional association between thymic shared antigen-1/stem cell antigen-2 and the T cell receptor complex. J Biol Chem 273:12301-12306.
15. MacNeil I, Kennedy J, Godfrey DI, Jenkins NA, Masciantonio M, Mineo C, Gilbert DJ, Copeland NG, Boyd RL, Zlotnik A. 1993. Isolation of a cDNA encoding thymic shared antigen-1. A new member of the Ly6 family with a possible role in T cell development. J Immunol 151:6913-6923.
16. Mirosavljevic D, Quinn JM, Elliott J, Horwood NJ, Martin TJ, Gillespie MT. 2003. T-cells mediate an inhibitory effect of interleukin-4 on osteoclastogenesis. J Bone Miner Res 18:984-993.
17. Nagata N, Kitaura H, Yoshida N, Nakayama K. 2003. Inhibition of RANKL-induced osteoclast formation in mouse bone marrow cells by IL-12: Involvement of IFN-gamma possibly induced from non-T cell population. Bone 33:721-732.
18. Robinson DS, O'Garra A. 2002. Further checkpoints in Th1 development. Immunity 16:755-758.
19. Roodman GD. 1996. Advances in bone biology: The osteoclast. Endocr Rev 17:308-332.
20. Roodman GD. 1999. Cell biology of the osteoclast. Exp Hematol 27:1229-1241.
21. Srinivasan S, Ito M, Kajiya H, Key LL, Jr., Johnson-Pais TL, Reddy SV. 2006. Functional characterization of human osteoclast inhibitory peptide-1 (OIP-1/ hSca) gene promoter. Gene 371:16-24.
22. Takayanagi H, Ogasawara K, Hida S, Chiba T, Murata S, Sato K, Takaoka A, Yokochi T, Oda H, Tanaka K, Nakamura K, Taniguchi T. 2000. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature 408:600-605.
23. Watford WT, Moriguchi M, Morinobu A, O'Shea JJ. 2003. The biology of IL- 12: Coordinating innate and adaptive immune responses. Cytokine Growth Factor Rev 14:361-368.
24. Yamada N, Niwa S, Tsujimura T, Iwasaki T, Sugihara A, Futani H, Hayashi S, Okamura H, Akedo H, Terada N. 2002. Interleukin-18 and interleukin-12 synergistically inhibit osteoclastic bone-resorbing activity. Bone 30:901-908.
25. Ylikoski E, Lund R, Kylaniemi M, Filen S, Kilpelainen M, Savolainen J, Lahesmaa R. 2005. IL-12 up-regulates T-bet independently of IFN-gamma in human CD4+ T cells. Eur J Immunol 35:3297-3306.