"Evidence that an early pregnancy causes a persistent decrease in the number of functional mammary epithelial stem cells - Implications for pregnancy-induced protection against breast cancer" by Siwko et al.

Stem Cells

Volumn 27, Issue 5, 2009, Pages 1223-

  Smith, Gilbert H ^a   Salomon, David S ^a   Vonderhar, Barbara K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; PROTEIN P53;

BREAST CANCER; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CANCER HORMONE THERAPY; CANCER MODEL; CANCER PREVENTION; CANCER RISK; CELL ACTIVITY; CELL COUNT; CELL FUNCTION; FIRST TRIMESTER PREGNANCY; GENE OVEREXPRESSION; GENETIC HETEROGENEITY; LETTER; NONHUMAN; PARITY; PRECANCER; STEM CELL; THIRD TRIMESTER PREGNANCY; TRANSGENIC MOUSE; ANIMAL; BREAST TUMOR; CYTOLOGY; EPITHELIUM CELL; FEMALE; FLOW CYTOMETRY; MOUSE; NOTE; PATHOLOGY; PHYSIOLOGY; PREGNANCY; TRANSPLANTATION; UDDER;

ANIMALS; BREAST NEOPLASMS; CELL COUNT; EPITHELIAL CELLS; FEMALE; FLOW CYTOMETRY; MAMMARY GLANDS, ANIMAL; MICE; PREGNANCY; STEM CELLS;

EID: 66149185429     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.19     Document Type: Letter

References (6)

1. Moon RC. Relationship between previous reproductive history and chemically induced mammary cancer in rats. Int J Cancer 1969;4:312-317.
2. Abrams TJ, Guzman RC, Swanson SM et al. Changes in the parous rat mammary gland environment are involved in parity-associated protection against mammary carcinogenesis. Anticancer Res 1998;18:4115-4121. (Pubitemid 29043622)
3. Rajkumar L, Kittrell FS, Guzman RC et al. Hormone-induced protection of mammary tumorigenesis in genetically engineered mouse models. Breast Cancer Res 2007;9:R12. (Pubitemid 350215149)
4. Smith GH, Medina D. A morphologically distinct candidate for an epithelial stem cell in mouse mammary gland. J Cell Sci 1988;90(Part 1):173-183. (Pubitemid 18128164)
5. Thordarson G, Jin E, Guzman RC et al. Refractoriness to mammary tumorigenesis in parous rats: Is it caused by persistent changes in the hormonal environment or permanent biochemical alterations in the mammary epithelia?Carcinogenesis 1995;16:2847-2853.
6. Moraes RC, Zhang X, Harrington N et al. Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia. Development 2007;134:1231-1242. (Pubitemid 46630090)