Differential expression of vascular endothelial growth factor (VEGF) and VEGF receptors in the sequence of hyperplastic polyp, serrated adenoma and adenocarcinoma of colorectum

Acta Medica Nagasakiensia

Volumn 53, Issue 4, 2008, Pages 85-88

  Taba, Mitsuru ^a   Nakayama, Toshiyuki ^a   Naito, Shinji ^b   Mihara, Yumi ^a   Miura, Shiro ^a   Naruke, Yuki ^a   Sekine, Ichiro ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b Industrial Technology Center of Nagasaki   (Japan)

Author keywords

Adenocarcinoma; Hyperplastic polyp; Serrated adenoma; VEGF; Vegf receptor

Indexed keywords

VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ADENOMA; ARTICLE; COLON ADENOCARCINOMA; COLON ADENOMA; COLON POLYP; CYTOPLASM; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; POLYP; PROTEIN EXPRESSION; RECTUM ADENOMA; RECTUM CARCINOMA; RECTUM POLYP; TUMOR CELL;

EID: 66149171660     PISSN: 00016055     EISSN: 00016055     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Huang CS, O'brien MJ, Yang S, Farraye FA. Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathway. Am J Gastroenterol 99: 2242-2255, 2004
2. Kambara T, Simms LA, Whitehall VL et al. BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 53: 1137-44, 2004 (Pubitemid 38961968)
3. Hawkins NJ, Bariol C, Ward RL. The serrated neoplasia pathway Pathology 34: 548-555, 2002 (Pubitemid 36026730)
4. Hawkins NJ, Ward RL. Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas. J Natl Cancer Inst 93: 1307-1313, 2001
5. Rex DK, Smith JJ, Ulbright TM, Lehman GA. Distal colonic hyperplastic polyps do not predict proximal adenomas in asymptomatic average-risk subjects. Gastroenterol 102: 317-319, 1992
6. T Higuchi, J R Jass. My approach to serrated polyps of the colorectum. J Clin Pathol 57: 682-686, 2004
7. Snover DC, Jass JR, Fenoglio-Preiser C, Batts KP. Serrated polyps of the large intestine: a morphologic and molecular review of an evolving concept. Am J Clin Pathol 124: 380-391, 2005 (Pubitemid 41232924)
8. Longacre TA, Fenoglio-Preiser CM. Mixed hyperplastic adenomatous polyps/serrated adenomas: a distinct form of colorectal neoplasia. Am J Surg Pathol 14: 524-37, 1990
9. Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 6: 389-395, 2000 (Pubitemid 30208155)
10. Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2: 795-893, 2002 (Pubitemid 37328914)
11. Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Cline Invest 103: 159-165, 1999 (Pubitemid 29053133)
12. Carmaliet P, Jain RK. Angiogenesis in cancer and the other diseases. Nature 407: 249-257, 2000
13. Ferrara N, Alitalo K. Clinical applications of angiogenic growth factors and their inhibitors. Nat Med 5: 1359-1364, 1999
14. Dvorak HF, Brown LF, Detmar M, Dvorak AM. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pahtol 146: 1029-1039, 1995
15. Kim SJ, Seo JH, Lee YJ et al. Autocrine vascular endothelial growth factor/vascular endothelial growth factor receptor-2 growth pathway represents a cyclooxygenase-2-independent target for the cyclooxygenase-2 inhibitor NS-398 in colon cancer cells. Oncology 68: 204-211, 2005
16. Yokoi K, Thaker PH, Yazici S et al. Dual inhabitation of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis human colon carcinoma in an orthotopic nude mouse model. Cancer Res 65: 3716-3725, 2005 (Pubitemid 40616349)
17. Guo P, Fang Q, Tao HQ et al. Overexpression of vascular endothelial growth factor by MCF-7 breast cancer cells promotes estrogen-independent tumor growth in vivo. Cancer Res 63: 4684-4691, 2003 (Pubitemid 36951048)
18. Barozzi C, Ravaioli M, D'Errico A et al. Relevance of biologic markers in colorectal carcinoma: a comparative study of a broad panel. Cancer 94: 647-657, 2002 (Pubitemid 34132292)
19. Schlemper RJ, Riddell RH, Kato Y et al. The Vienna classification of gastrointestinal epithelial neoplasia. Gut 47: 251-255, 2000 (Pubitemid 30489769)
20. Nakayama T, Cho YC, Mine Y et al. Expression of vascular endothelial growth factor and its receptors VEGFR-1 and 2 in gastrointestinal stromal tumors, leiomyomas and schwannomas. World J Gastroenterol 12: 6182-6187, 2006 (Pubitemid 44688169)
21. Garvin S, Nilsson UW, Dabrosin C. Effects of oestradiol and tamoxifen on VEGF, soluble VEGFR-1, and VEGFR-2 in breast cancer and endothelial cells. Br J Cancer 93: 1005-1010, 2005 (Pubitemid 41548394)
22. Jass JR, Whitehall VL, Young J, Leggett BA. Emerging concepts in colorectal neoplasia. Gastroenterol 123: 862-876, 2002
23. Powell SM, Petersen GM, Krush AJ et al. Molecular diagnosis of familial adenomatous polyposis. N Engl J med 329: 1982-1987, 1993
24. Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal carcinomas. Nature 386: 623-627, 1997 (Pubitemid 27175430)
25. Tighe A, Johnson VL, Taylor SS. Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability. J Cell Sci 117: 6339-6353, 2004 (Pubitemid 40214561)
26. Yang S, Farraye FA, Mack C, Posnik O, O'Brien MJ. BRAF and KRAS mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. Am J Surg Pathol 28: 1452-1459, 2004 (Pubitemid 39425511)
27. Folkman J. The role of angiogenesis in tumor growth. Semin Cancer Biol 3: 65-71, 1992
28. Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82: 4-6, 1990 (Pubitemid 20020880)
29. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 324: 1-8, 1991
30. Liotta LA, Kleinerman J, Saidel GM. Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res 34: 997-1004, 1974
31. Takahashi Y, Kitadai Y, Bucana CD, Cleary KR, Ellis LM. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 55: 3964-3968, 1995
32. Staton CA, Chetwood AS, Cameron IC, Cross SS, Brown NJ, Reed MW. The angiogenic switch occurs at the adenoma stage of the adenoma carcinoma sequence in colorectal cancer. Gut 56: 1426-1432, 2007
33. Lee JC, Chow NH, Wang ST, Huang SM. Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients. Eur J Cancer 36: 748-753, 2000