Dengue-4 envelope domain III fused twice within the meningococcal P64k protein carrier induces partial protection in mice

Biotechnology and Applied Biochemistry

Volumn 52, Issue 4, 2009, Pages 265-271

  Lazo, Laura ^a   Zulueta, Aída ^a   Hermida, Lisset ^a   Blanco, Aracelys ^a   Sánchez, Jorge ^a   Valdés, Iris ^a   Gil, Lázaro ^a   López, Carlos ^a   Romero, Yaremis ^a   Guzmán, María G ^b   Guillén, Gerardo ^a  

^a CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

^b WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

Dengue 4 envelope domain III; Flavivirus; Meningococcal p64k protein carrier; Vaccine

Indexed keywords

C-TERMINUS; DENGUE VIRUS; DENGUE-4 ENVELOPE DOMAIN III; EXPRESSION IN ESCHERICHIA COLI; FLAVIVIRUS; FUSION PROTEINS; HIGH MOLECULAR MASS; IMMUNE RESPONSE; IMMUNOGENICITY; LOW LEVEL; MENINGOCOCCAL P64K PROTEIN CARRIER; MURINE MODEL; POLYCLONAL ANTIBODY; PROTECTIVE CAPACITY; PROTEIN CARRIER; RECOMBINANT PROTEIN; SEROTYPE; SEROTYPES;

AMINES; AMINO ACIDS; ANIMALS; ESCHERICHIA COLI; IMMUNOLOGY; ORGANIC ACIDS; VACCINES;

ANTIBODIES;

ALUMINUM HYDROXIDE; DENGUE VIRUS SEROTYPE 4 ENVELOPE DOMAIN III PROTEIN PD24 FUSION PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN G; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; DENGUE VACCINE; GLYCOPROTEIN E, DENGUE VIRUS TYPE 4; LPDA PROTEIN, NEISSERIA MENINGITIDIS; OUTER MEMBRANE PROTEIN; VIRUS ENVELOPE PROTEIN;

ACTIVE IMMUNIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; CHIMERA; CONTROLLED STUDY; DENGUE; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; EXPERIMENTAL INFECTION; FEMALE; GENE CONSTRUCT; GENE EXPRESSION; GENE INSERTION; HUMORAL IMMUNITY; IMMUNOGENICITY; MOLECULAR CLONING; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PROTEIN DOMAIN; PROTEIN PURIFICATION; SEROTYPE; VACCINE PRODUCTION; VIRUS ENCEPHALITIS; ANIMAL; BAGG ALBINO MOUSE; GENETICS; METABOLISM; TREATMENT OUTCOME; VIROLOGY;

ANIMALIA; DENGUE VIRUS; ESCHERICHIA COLI; FLAVIVIRUS; MURINAE; MUS;

ANIMALS; BACTERIAL OUTER MEMBRANE PROTEINS; DENGUE; DENGUE VACCINES; FEMALE; MICE; MICE, INBRED BALB C; RECOMBINANT FUSION PROTEINS; TREATMENT OUTCOME; VIRAL ENVELOPE PROTEINS;

EID: 66149156249     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20080074     Document Type: Article

References (25)

1. Khanam, S., Etemad, B., Khanna, N. and Swaminathan, S. (2006) Am. J. Trop. Med. Hyg. 74, 266-277
2. Chanthavanich, P., Luxemburger, C., Sirivichayakul, C., Lapphra, K., Pengsaa, K., Yoksan, S., Sabchareon, A. and Lang, J. (2006) Am. J. Trop. Med. Hyg. 75, 26-28
3. Sabchareon, A., Lang, J., Chanthavanich, P., Yoksan, S., Forrat, R., Attanath, P., Sirivichayakul, C., Pengsaa, K., Pojjaroen-Anant, C., Chokejindachai, W. et al. (2002) Am. J. Trop. Med. Hyg. 66, 264-272
4. Sabchareon, A., Lang, J., Chanthavanich, P., Yoksan, S., Forrat, R., Attanath, P., Sirivichayakul, C., Pengsaa, K., Pojjaroen-Anant, C., Chambonneau, L. et al. (2004) Pediatr. Infect. Dis J. 23, 99-109
5. Sun, W., Edelman, R., Kanesa-Thasan, N., Eckels, K. H., Putnak, J. R., King, A. D., Houng, H. S., Tang, D., Scherer, J. M., Hoke, Jr, C. H. and Innis, B. L. (2003) Am. J. Trop. Med. Hyg. 69, 24-31
6. Simmons, M., Murphy, G. S. and Hayes, C. G. (2001) Am. J. Trop. Med. Hyg. 65, 159-161
7. Zulueta, A., Hermida, L., Lazo, L., Valdés, I., Rodríguez, R., López, C., Silva, R., Rosario, D., Martín, J., Guzmán, M. G. and Guillén, G. (2003) Biochem. Biophys. Res. Commun. 308, 619-626.
8. Hermida, L., Rodríguez, R., Lazo, L, Bernardo, L., Silva, R., Zulueta, A., López, C., Martín, J., Valdés, I., Del Rosario, D. et al. (2004) Biotechnol. Appl. Biochem. 39, 107-114
9. Hermida, L., Rodríguez, R., Lazo, L., Silva, R., Zulueta, A., Chinea, G., López, C., Guzmán, M. G. and Guillén, G. (2004) J. Virol. 115, 41-49.
10. Clarke, D. H. and Casals, J. (1989) Am. J. Trop. Med. Hyg. 7, 561-573
11. Sambrook, J., Fritsch, E. F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
12. Brown, R., Jarvis, K. and Hyland, K. (1989) Anal Biochem. 180, 136-139
13. Laemmli, U. K. (1970) Nature 227, 680-683
14. Hermida, L., Bernardo, L., Martín, J., Alvarez, M., Prado, I., Lopez, C., Sierra, B., Martínez, R., Rodrígues, R., Zulueta, A. et al. (2006) Vaccine 24, 3165-3171
15. Towbin, H., Staehelin, T. and Gordon, H. (1979) Proc. Natl. Acad. Sci. U.S.A. 76, 4350-4354
16. Morens, D. M., Halstead, S. B. and Repik, P. M. (1985) J. Clin. Microbiol. 22, 250-254
17. López, C., Sánchez, J., Hermida, L., Zulueta, A. and Márquez, G. (2004) Protein Expression Purif. 34, 176-182
18. Chen, Y., Maguire, T. and Marks, R. M. (1996) J. Virol. 70, 8765-8772
19. Mota, J., Acosta, M., Argotte, R., Figueroa, R., Méndez, A. and Ramos, C. (2005) Vaccine 16, 3469-3476
20. Volk, D. E., Lee, Y. C., Li, X., Thiviyanathan, V., Gromowski, G. D., Li, L., Lamb, A. R. and Beasley, D. W. (2007) Virology 364, 147-154
21. Sousa, C. R. and Germain, N. R. (1995) J. Exp. Med. 182, 241-251
22. Vaughn, D. W. (2000) Am. J. Epidemiol. 152, 800-803
23. Barrett, A. D., Gorenstein, D. G., Clarke, D. H. and Casals, J. (1958) Am. J. Trop. Med. Hyg. 7, 561-573
24. Lazo, L., Hermida, L., Zulueta, A., Sanchez, J., Lopez, C., Silva, R., Guillen, G. and Guzman, M. G. (2007) Vaccine 25, 1064-1070
25. Van der most, R., Murali-krishna, K., Ahmed, R. and Strauss, J. (2000) J. Virol. 74, 8094-8101