Quantitative PET analysis of the dopamine D2 receptor agonist radioligand 11C-(R)-2-CH3O-N-n-propylnorapomorphine in the human brain

Journal of Nuclear Medicine

Volumn 50, Issue 5, 2009, Pages 703-710

  Otsuka, Tatsui ^a,b   Ito, Hiroshi ^a   Halldin, Christer ^c   Takahashi, Hidehiko ^a   Takano, Harumasa ^a   Arakawa, Ryosuke ^a   Okumura, Masaki ^a   Kodaka, Fumitoshi ^a   Miyoshi, Michie ^a   Sekine, Mizuho ^a   Seki, Chie ^a   Nakao, Ryuji ^a   Suzuki, Kazutoshi ^a   Finnema, Sjoerd ^c   Hirayasu, Yoshio ^b   Suhara, Tetsuya ^a   Farde, Lars ^c  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

11C MNPA; Agonist; Dopamine D2 receptor; Human; Positron emission tomography

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR STIMULATING AGENT; PROPYLNORAPOMORPHINE; RADIOLIGAND;

ADULT; ARTICLE; BRAIN RADIOGRAPHY; CAUDATE NUCLEUS; CEREBELLUM; CONTROLLED STUDY; DRUG DISTRIBUTION; HUMAN; HUMAN EXPERIMENT; MALE; MOLECULAR IMAGING; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; THALAMUS;

ADULT; APOMORPHINE; BRAIN; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALE; METABOLIC CLEARANCE RATE; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RECEPTORS, DOPAMINE D2; TISSUE DISTRIBUTION; YOUNG ADULT;

EID: 66149149876     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.108.058503     Document Type: Article

References (36)

1. Montague PR, Hyman SE, Cohen JD. Computational roles for dopamine in behavioural control. Nature. 2004;431:760-767.
2. Carlsson A. Antipsychotic drugs, neurotransmitters, and schizophrenia. Am J Psychiatry. 1978;135:165-173.
3. Ehringer H, Hornykiewicz O. Klin Wochenschr. 1960;38:1236-1239.
4. Volkow ND, Fowler JS, Wang GJ, Swanson JM. Dopamine in drug abuse and addiction: results from imaging studies and treatment implications. Mol Psychiatry. 2004;9:557-569.
5. Strange PG. New insights into dopamine receptors in the central nervous system. Neurochem Int. 1993;22:223-236.
6. 2 receptor occupancy in living human brain from plasma pharmacokinetics of antipsychotics. Int J Neuropsychopharmacol. 2004;7:19-26.
7. 2 receptor binding in subregions of the thalamus in schizophrenia. Am J Psychiatry. 2004;161:1016-1022.
8. 2 receptor binding in the anterior cingulate cortex in schizophrenia. Arch Gen Psychiatry. 2002;59:25-30.
9. 2-dopamine receptor occupancy with risperidone. Psychopharmacology (Berl). 2001;154:112-114.
10. 11C]raclopride and positron emission tomography. Psychiatry Res. 2006;148:165-173.
11. 11C]FLB 457. Int J Neuropsychopharmacol. 2003;6:361-370.
12. 2 dopamine receptor. J Biol Chem. 1982;257:6351-6361.
13. Halldin C, Gulyas B, Langer O, Farde L. Brain radioligands: state of the art and new trends. Q J Nucl Med. 2001;45:139-152.
14. 11C]FLB 457 binding to extrastriatal dopamine receptors in the human brain. J Cereb Blood Flow Metab. 1999;19:1164-1173.
15. 2-dopamine receptors studied by PET: a comparison to the equilibrium analysis. J Cereb Blood Flow Metab. 1989;9:696-708.
16. 2 receptors. Nucl Med Biol. 2000;27:533-539.
17. 2 high-affinity state with positron emission tomography. J Med Chem. 2005;48:4153-4160.
18. Gao YG, Baldessarini RJ, Kula NS, Neumeyer JL. Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues. J Med Chem. 1990;33:1800-1805.
19. 2 agonist. J Med Chem. 1990;33:3122-3124.
20. 11C]MNPA in cynomolgus monkey. Nucl Med Biol. 2005;32:353-360.
21. 11C] raclopride. Synapse. 2006;59:260-269.
22. Friston KJ, Frith CD, Liddle PF, Dolan RJ, Lammertsma AA, Frackowiak RS. The relationship between global and local changes in PET scans. J Cereb Blood Flow Metab. 1990;10:458-466.
23. Innis RB, Cunningham VJ, Delforge J, et al. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab. 2007;27:1533-1539. (Pubitemid 47301451)
24. 125I] iodosulpride, a highly selective ligand. Science. 1985;228:752-755.
25. 2 dopamine receptors in the human brain. Neuroimage. 2001;13:531-539.
26. 11C]DOPA. Nucl Med Commun. 2006;27:723-731.
27. Lammertsma AA, Hume SP. Simplified reference tissue model for PET receptor studies. Neuroimage. 1996;4:153-158.
28. 11C]raclopride binding. J Cereb Blood Flow Metab. 1998;18:941-950.
29. Hatazawa J, Fujita H, Kanno I, et al. Regional cerebral blood flow, blood volume, oxygen extraction fraction, and oxygen utilization rate in normal volunteers measured by the autoradiographic technique and the single breath inhalation method. Ann Nucl Med. 1995;9:15-21.
30. Renkin EM. Transport of potassium-42 from blood to tissue in isolated mammalian skeletal muscles. Am J Physiol. 1959;197:1205-1210.
31. Crone C. The permeability of capillaries in various organs as determined by use of the 'indicator diffusion' method. Acta Physiol Scand. 1963;58:292-305.
32. 11C]-(1)-PHNO. Biol Psychiatry. 2006;59:389-394.
33. Ito H, Takahashi H, Arakawa R, Takano H, Suhara T. Normal database of dopaminergic neurotransmission system in human brain measured by positron emission tomography. Neuroimage. 2008;39:555-565.
34. 11C] raclopride in man. Synapse. 1995;20:200-208.
35. 11C]MNPA in the monkey brain using PET [abstract]. Eur J Nucl Med Mol Imaging. 2005;32(S82):293.
36. 2 receptors in vivo using positron emission tomography. J Neurochem. 2006;97:1089-1103.