Abnormal expression of MMP-9 and imbalance of MMP-9/TIMP-1 is associated with prolonged uterine bleeding after a medical abortion with mifepristone and misoprostol

Acta Obstetricia et Gynecologica Scandinavica

Volumn 88, Issue 6, 2009, Pages 673-679

  Li, Li ^a   Zhou, Zanhua ^b   Huang, Lili ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Lishui Medical College   (China)

Author keywords

Endometrium; Medical abortion; MMP 9; Prolonged uterine bleeding

Indexed keywords

GELATINASE B; MIFEPRISTONE; MISOPROSTOL; TISSUE INHIBITOR OF METALLOPROTEINASE 1; ABORTIVE AGENT;

ADULT; ARTICLE; CLINICAL ARTICLE; ENDOMETRIUM; FEMALE; FIRST TRIMESTER PREGNANCY; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; MEDICAL ABORTION; MENSTRUAL CYCLE; PRIORITY JOURNAL; PROLONGED UTERUS BLEEDING; PROTEIN EXPRESSION; REPEATED DRUG DOSE; UTERINE BLEEDING PATTERN; UTERUS BLEEDING; BIOSYNTHESIS; CROSS-SECTIONAL STUDY; INDUCED ABORTION; METABOLISM; METHODOLOGY; PREGNANCY;

ABORTIFACIENT AGENTS; ABORTION, INDUCED; ADULT; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MATRIX METALLOPROTEINASE 9; MIFEPRISTONE; MISOPROSTOL; PREGNANCY; TISSUE INHIBITOR OF METALLOPROTEINASE-1; UTERINE HEMORRHAGE;

EID: 66149141431     PISSN: 00016349     EISSN: 16000412     Source Type: Journal    
DOI: 10.1080/00016340902898024     Document Type: Article

References (28)

1. Cheng L. Medical abortion in early pregnancy: experience in China. Contraception. 2006;74:61-5.
2. Tang OS, Gao PP, Cheng L, Lee SW, Ho PC. A randomized double-blind placebo-controlled study to assess the effect of oral contraceptive pills on the outcome of medical abortion with mifepristone and misoprostol. Hum Reprod. 1999;14: 722-5.
3. Page-McCaw A, Ewald AJ, Werb Z. Matrix metalloprotei-nases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol. 2007;8:221-33.
4. Jiang Y, Goldberg ID, Shi YE. Complex roles of tissue inhibitors of metalloproteinases in cancer. Oncogene. 2002; 21:2245-52.
5. Curry TE Jr, Osteen KG. Cyclic changes in the matrix metalloproteinase system in the ovary and uterus. Biol Reprod. 2001;64:1285-96.
6. Zhang X, Nothnick WB. The role and regulation of the uterine matrix metalloproteinase system in menstruating and non-menstruating species. Front Biosci. 2005;10:353-66.
7. Cornet PB, Galant C, Eeckhout Y, Courtoy PJ, Marbaix E, Henriet P. Regulation of matrix metalloproteinase-9/gelati-nase B expression and activation by ovarian steroids and LEFTY-A/endometrial bleeding-associated factor in the human endometrium. J Clin Endocrinol Metab. 2005;90: 1001-11.
8. Galant C, Berliere M, Dubois D, Verougstraete JC, Charles A, Lemoine P, et al. Focal expression and final activity of matrix metalloproteinases may explain irregular dysfunctional endometrial bleeding. Am J Pathol. 2004;165:83-94.
9. Galant C, Vekemans M, Lemoine P, Kokorine I, Twagirayezu P, Henriet P, et al. Temporal and spatial association of matrix metalloproteinases with focal endometrial breakdown and bleeding upon progestin-only contraception. J Clin Endocrinol Metab. 2000;85:4827-34.
10. Zhong Y, Shi X, Weng L. Study on mechanism of prolonged bleeding after mifepristone medical abortion. Reproduction and Contraception. 2004;24:149-52.
11. Salamonsen LA, Lathbury LJ. Endometrial leukocytes and menstruation. Hum Reprod Update. 2000;6:16-27.
12. Ferenczy A. Pathophysiology of endometrial bleeding. Ma-turitas. 2003;45:1-14.
13. Iwahashi M, Nakano R. Decreased type V collagen expression in human decidual tissues of spontaneous abortion during early pregnancy. J Clin Pathol. 1998;51:/44-6.
14. Iwahashi M, Muragaki Y, Ooshima A, Nakano R. Decreased type IV collagen expression by human decidual tissues in spontaneous abortion. J Clin Endocrinol Metab. 1996;81: 2925-9.
15. Christin-Maitre S, Bouchard P, Spitz IM. Medical termination of pregnancy. N Engl J Med. 2000;342:946-56.
16. Jeziorska M, Nagase H, Salamonsen LA, Woolley DE. Immunolocalization of the matrix metalloproteinases gelati-nase B and stromelysin 1 in human endometrium throughout the menstrual cycle. J Reprod Fertil. 1996;107:43-51.
17. Zhang J, Salamonsen LA. Tissue inhibitor of metalloproteinases (TIMP)-1, -2 and -3 in human endometrium during the menstrual cycle. Mol Hum Reprod. 1997;3:735-41.
18. Jabbour HN, Kelly RW, Fraser HM, Critchley HO. Endocrine regulation of menstruation. Endocr Rev. 2006;27: 17-46.
19. Tsatas D, Baker MS, Rice GE. Differential expression of proteases in human gestational tissues before, during and after spontaneous-onset labour at term. J Reprod Fertil. 1999; 116:43-9.
20. Salamonsen LA, Butt AR, Hammond FR, Garcia S, Zhang J. Production of endometrial matrix metalloproteinases, but not their tissue inhibitors, is modulated by progesterone withdrawal in an in vitro model for menstruation. J Clin Endocrinol Metab. 1997;82:1409-15.
21. Vassilev V, Pretto CM, Cornet PB, Delvaux D, Eeckhout Y, Courtoy PJ, et al. Response of matrix metalloproteinases and tissue inhibitors of metalloproteinases messenger ribonucleic acids to ovarian steroids in human endometrial explants mimics their gene- and phase-specific differential control in vivo. J Clin Endocrinol Metab. 2005;90:5848-57.
22. Zhang J, Hampton AL, Nie G, Salamonsen LA. Progesterone inhibits activation of latent matrix metalloproteinase (MMP)-2 by membrane-type 1 MMP: enzymes coordinately expressed in human endometrium. Biol Reprod. 2000;62: 85-94.
23. Zhang J, Salamonsen LA. In vivo evidence for active matrix metalloproteinases in human endometrium supports their role in tissue breakdown at menstruation. J Clin Endocrinol Metab. 2002;87:2346-51.
24. Zhang X, Xiao D, Yao N. Expression of MMPs in deciduous and villi of women with medical abortion and artificial abortion. J Huazhong Univ Sci Tech. 2002;31:570-2.
25. Salamonsen LA. Tissue injury and repair in the female human reproductive tract. Reproduction. 2003;125:301-11.
26. Guedez L, McMarlin AJ, Kingma DW, Bennett TA, Stetler-Stevenson M, Stetler-Stevenson WG. Tissue inhibitor of metalloproteinase-1 alters the tumorigenicity of Burkitt's lymphoma via divergent effects on tumor growth and angio-genesis. Am J Pathol. 2001;158:1207-15.
27. Plaisier M, Kapiteijn K, Koolwijk P, Fijten C, Hanemaaijer R, Grimbergen JM, et al. Involvement of membrane-type matrix metalloproteinases (MT-MMPs) in capillary tube formation by human endometrial microvascular endothelial cells: role of MT3-MMP. J Clin Endocrinol Metab. 2004;89:5828-36.
28. Hickey M, Higham J, Sullivan M, Miles L, Fraser IS. Endometrial bleeding in hormone replacement therapy users: preliminary findings regarding the role of matrix metalloproteinase 9 (MMP-9) and tissue inhibitors of MMPs. Fertil Steril. 2001;75:288-96.