Endometrial bleeding in hormone replacement therapy users: Preliminary findings regarding the role of matrix metalloproteinase 9 (MMP-9) and tissue inhibitors of MMPs

Fertility and Sterility

Volumn 75, Issue 2, 2001, Pages 288-296

  Hickey, Martha ^a,b,c,d   Higham, Jenny ^a,b,c   Sullivan, Mark ^a,b,c   Miles, Lyn ^a,b,c   Fraser, Ian S ^a,b,c  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b QUEEN CHARLOTTE S AND CHELSEA HOSPITAL   (United Kingdom)

^c UNIVERSITY OF SYDNEY   (Australia)

^d ST MARY S HOSPITAL   (United Kingdom)

Author keywords

Bleeding; Endometrium; Menopause; MMP 9; TIMP 1

Indexed keywords

CYPROTERONE ACETATE; DYDROGESTERONE; ESTROGEN; GELATINASE B; GESTAGEN; LEVONORGESTREL; MEDROXYPROGESTERONE ACETATE; NORETHISTERONE; NORGESTREL; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOMETRIUM; ENDOMETRIUM BIOPSY; FEMALE; HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; IN SITU HYBRIDIZATION; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VAGINA BLEEDING;

BASE SEQUENCE; BIOPSY; ENDOMETRIUM; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; FEMALE; GENE EXPRESSION; HUMANS; IN SITU HYBRIDIZATION; MATRIX METALLOPROTEINASE 9; MENOPAUSE; MOLECULAR SEQUENCE DATA; POSTMENOPAUSE; PROGESTINS; PROSPECTIVE STUDIES; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-1; UTERINE HEMORRHAGE;

EID: 0035142761     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(00)01690-3     Document Type: Article

References (24)

1. Regular bleeding on hormone replacement therapy; a myth?
2. What women want from hormone replacement therapy; results of an international survey
3. Unexpected vaginal bleeding and associated gynecologic care in postmenopausal women using hormone replacement therapy; comparison of cyclic versus continuous combined schedules
4. Women's beliefs and decisions about hormone replacement therapy
5. A review of the role of progestogens in hormone replacement therapy; influence on bleeding patterns
6. Expression of messenger ribonucleic acid encoding matrix metalloproteinases and their tissue inhibitors is related to menstruation
7. Focal cellular origin and regulation of interstitial collagenase (matrix metalloproteinase-1) are related to menstrual breakdown in the human endometrium
8. Menstrual breakdown on human endometrium can be mimicked in vitro and is selectively and reversibly blocked by inhibitors of matrix metalloproteinases
9. Immunolocalisation of the matrix metalloproteinases gelatinase B and stromolysin 1 in human endometrium throughout the menstrual cycle
10. Matrix metalloproteinases as mediators of reproductive function
11. Progesterone regulates the activity of collagenase and related gelatinases A and B in human endometrial explants
12. Production of endometrial matrix metalloproteinases, but not their tissue inhibitors, is modulated by progesterone withdrawal in an in vitro model for menstruation
13. Expression and localization of matrilysin, a matrix metalloproteinase, in human endometrium during the reproductive cycle
14. Changes in endothelial cell basement membrane in Norplant users
15. Matrix metalloproteinases in normal menstruation
16. Matrix metalloproteinase and matrix metalloproteinase inhibitor expression in endometrial stromal cells during progestin-initiated decidualization and menstruation-related progestin withdrawal
17. Impications of decidualized-associated protease expression in implantation and menstruation
18. Mechanisms of menstrual bleeding; dysfunctional uterine bleeding and break-through bleeding
19. The endometrial vasculature in Norplant users; preliminary results from an hysteroscopic study
20. Superficial endometrial vascular fragility in Norplant users and in women with ovulatory dysfunctional uterine bleeding
21. Progestin receptor isoforms and prostaglandin dehydrogenase in the endometrium of women using a levonorgestrel-releasing intrauterine system
22. Endometrial breakdown in women using Norplant is associated with migratory cells expressing matrix metalloproteinase-9 (gelatinase B)
23. Regulation of matrix metalloproteinase-9 in endometrium during the menstrual cycle and following administration of intrauterine levonorgestrel
24. Disturbances of bleeding with hormone replacement therapy