Periodic fermentor yield and enhanced product enrichment from autonomous oscillations

Applied Biochemistry and Biotechnology

Volumn 156, Issue 1-3, 2009, Pages 59-75

  Stowers, Chris C ^a   Robertson, J Brian ^b   Ban, Hyunju ^c   Tanner, Robert D ^a   Boczko, Erik M ^c  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Ambient biocomplexity; Enrichment ratio; Mitotic cell cycle; Protein purification

Indexed keywords

AMBIENT BIOCOMPLEXITY; AUTONOMOUS OSCILLATION; BIOPROCESS CONTROL; CELL CYCLE; ENRICHMENT RATIO; EXPERIMENTAL DATA; FERMENTORS; MITOTIC CELL CYCLE; OPERATIONAL PARAMETERS; OSCILLATING SYSTEMS; OSCILLATORY PHENOMENA; POPULATION STRUCTURES; PROTEIN PURIFICATION; SUBSTRATE CONVERSION; YEAST CULTURE; YEAST GROWTH;

BIOMASS; CELL MEMBRANES; MATHEMATICAL MODELS; PURIFICATION; YEAST;

CELL CULTURE;

BIOMASS; BIOPROCESS; BIOREACTOR; CELL CYCLE; CELL DENSITY; CONFERENCE PAPER; ENRICHMENT CULTURE; FUNGUS CULTURE; FUNGUS GROWTH; MATHEMATICAL MODEL; NONHUMAN; OSCILLATION; PROTEIN PURIFICATION; YEAST;

BIOMASS; BIOREACTORS; CELL CYCLE; CELL DIVISION; FERMENTATION; KINETICS; MODELS, BIOLOGICAL; OSCILLOMETRY; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCETALES;

EID: 66149138898     PISSN: 02732289     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12010-008-8486-7     Document Type: Conference Paper

References (35)

1. B. Dumas C. Masson K. Lebrun T. Achstetter 2006 Hydrocortisone made in yeast: metabolic engineering turns a unicellular microorganism into a drug-synthesis factory Biotechnology Journal 1 299 307
2. T. Kjeldsen S. Ludvigsen I. Diers P. Balshmidt A. Sorensen N. Kaarshold 2002 Engineering-enhanced protein secretory expression in yeast with applications to insulin Journal of Biological Chemistry 277 18245 18248
3. F. Szczebara C. Changelier C. Villeret C. Masurel A. Masurel S. Bourot 2003 Total biosynthesis of hydrocortisone from a simple carbon source in yeast Nature 21 143 149
4. L. Thim M. Hansen K. Norris I. Holegh E. Boel J. Forstrom 1986 Secretion and processing of insulin precursors in yeast PNAS 83 6766 6770
5. E. Chan C. Chen L. Chen 1992 Recovery of invertase from ethanol fermentation broth Biotechnology Letters 14 573 576
6. K. Uchiyama M. Morimoto Y. Yokoyama S. Shioya 1996 Cell cycle dependency of rice α-amylase production in a recombinant yeast Biotechnology and Bioengineering 54 262 271
7. V. Bansal P. Roychoudhurry B. Mattiasson A. Kumar 2006 Recovery of urokinase from integrated mammalian cell culture cryogel bioreactor and purification of the enzyme using p-aminobenzamidine affinity chromatography Journal of Molecular Recognition 19 332 339
8. L. Sajc D. Grubisic G. Novakovic 2000 Bioreactors for plant engineering: An outlook for further research Biochemical Engineering Journal 4 89 99
9. C. Smith 2005 Striving for purity: Advances in protein purification Nature 2 71 77
10. C. Stowers E. M. Boczko 2007 Reliable cell disruption in yeast Yeast 24 533 541
11. M. Gleeson C. White D. Meininger A. Komives 1998 Generation of protease-deficient strains and their use in heterologous protein expression Methods in Molecular Biology 103 81 94
12. L. Alberghina L. Mariani E. Martegani M. Vanoni 1983 Analysis of protein distribution in budding yeast Biotechnology and Bioengineering 15 1295 1310
13. M. Vanoni M. Vai L. Popolo L. Alberghina 1983 Structural heterogeneity in populations of budding yeast Saccharomyces cerevisiae Journal of Bacteriology 156 1282 1291
14. M. Hortso 1996 Population balance models of autonomous periodic dynamics in microbial cultures: Their use in process optimization Canadian Journal of Chemical Engineering 74 612 620
15. G. Walker 1999 Synchronization of yeast cell populations Methods in Cell Science 21 87 93
16. Stowers, C., Hackworth, D., Mischaikow, K., Gedeon, T., & Boczko, E. (2008). Extending synchrony and deconvolving population effects in budding yeast through an analysis of volume growth with a structured Leslie model. Theoretical Population Biology (in press).
17. P. Richard 2003 The rhythm of yeast FEMS Microbiology Reviews 27 547 557
18. Dawson, P. (1972). Continuous synchronous culture-The production of extracellular enzymes by continuous phased culture of Bacillus subtilis. Proceedings of the IV IFS: Ferment. Technol. Today, pp. 121-128.
19. M. Jules J. Francois J. Parrou 2005 Autonomous oscillations in Saccharomyces cerevisiae during batch cultures of trehalose FEBS Journal 272 1490 1500
20. K. H. Bellgardt 1994 Analysis of synchronous growth of bakers yeast. Part I: Development of a theoretical model for sustained oscillations Journal of Biotechnology 35 19 33
21. K. H. Bellgardt 1994 Analysis of synchronous growth of bakers yeast. Part II: Development of a theoretical model for sustained oscillations Journal of Biotechnology 35 35 49
22. M. Beuse R. Bartling A. Kopmann H. Deikmann M. Thoma 1998 Effect of the dilution rate on the mode of oscillation in continuous cultures of Saccharomyces cerevisiae Journal of Biotechnology 61 15 31
23. P. Crooke R. Tanner D. Park 1986 Time dependent differential yield as a scale-up parameter in enzyme and fermentation reactors Biotechnology Progress 2 40 47
24. C. Essajee R. D. Tanner 1979 The effect of extracellular variables on the stability of continuous baker's yeast-ethanol fermentation process Process Biochemistry 25 16 21
25. E. Heinzle I. Dunn K. Furukawa R. D. Tanner 1982
26. D. Murray R. Klevecz D. Lloyd 2003 Generation and maintenance of synchrony in Saccharomyces cerevisiae continuous culture Experimental Cell Research 287 10 15
27. B. P. Tu A. Kudlicki M. Rowicka S. L. McKnight 2006 Logic of the yeast metabolic cycle: Temporal compartmentalization of cellular processes Science 310 1152 1158
28. Z. Xu K. Tsurugi 2006 A potential mechanism of energy-metabolism oscillation in an aerobic chemostat culture of the yeast Saccharomyces cerevisiae FEBS Journal 273 1696 1709
29. S. Aldridge 1996 Downstream processing needs a boost Genetic Engineering and Biotechnology News 26 1
30. M. Ramesh N. Charyulu N. Chand B. Lonsane 2004 Non-growth associated production of enzymes in solid state fermentation systems: Its mathematical description for two enzymes produced by Bacillus licheniformis Bioprocess and Biosystems Engineering 15 289 294
31. O. Cos R. Ramon J. L. Luis Montesinos F. Valero 2006 Operational strategies, monitoring and control of heterologous protein production in the methylotrophis yeast Pichia pastoris under different promoters: a review Microbial Cell Factories 5 17
32. M. Taufer C. An A. Kerstens C. Brooks 2006 Predictor @ home: A "protein structure prediction supercomputer" based on global computing IEEE Transactions on Parallel and Distributed Systems 17 786 796
33. J. Qui W. Noble 2008 Predicting co-complexed protein pairs from heterogeneous data PLOS Computation Biology 4 e1000054
34. L. Hartwell 1974 Saccharomyces cerevisiae cell cycle Bacteriological Reviews 38 164 198
35. L. Hartwell M. Unger 1977 Unequal division in Saccharomyces cerevisiae and its implications for the control of the cell division Journal of Cell Biology 75 422 435 (Pubitemid 8204997)