Validation and application of an LC-ESI-MS method for simultaneous determination of astilbin and its major metabolite 3′-O-methylastilbin in rat plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 18-19, 2009, Pages 1765-1770

  Liang, Yan ^a   Xu, Qiang ^b   Kang, An ^a   Xie, Yuan ^a   Xie, Tong ^a   Liu, Li ^a   Hao, Haiping ^a   Xie, Lin ^a   Wang, Guang ji ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

3 O methylastilbin; Astilbin; LC ESI MS; Metabolite

Indexed keywords

ACCURACY AND PRECISION; ASTILBIN; CALIBRATION CURVES; CORRELATION COEFFICIENT; EXTRACTION EFFICIENCIES; GRADIENT ELUTION; IONIZATION MODES; LC-ESI-MS; LC-MS METHODS; MATRIX EFFECTS; PHARMACOKINETIC STUDIES; RAT PLASMA; RELATIVE DEVIATIONS; SIMPLE LIQUIDS; SIMULTANEOUS DETERMINATIONS; TEST RANGE;

BIOMOLECULES; IONIZATION OF LIQUIDS; LINEARIZATION; LIQUIDS; METABOLISM; METABOLITES; PLASMA (HUMAN); PLASMAS;

SOLVENT EXTRACTION;

3' O METHYLASTILBIN; ASTILBIN; FLAVONE DERIVATIVE; SILIBININ; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALIBRATION; DIAGNOSTIC ACCURACY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG ISOLATION; DRUG STABILITY; ELECTRON SPIN RESONANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CHROMATOGRAPHY, LIQUID; FLAVONOLS; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

RATTUS;

EID: 66149138875     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.04.040     Document Type: Article

References (13)

1. Zhou S., and Wang G. Curr. Drug Metab. 8 (2007) 526
2. Chu K.T. B. Biochem. Res. Commun. 340 (2006) 118
3. Chen T., and Xu Q. Phytochemistry 53 (2000) 1051
4. Wang J., and Xu Q. J. Pharm. Pharmacol. 56 (2004) 495
5. Ru Y., and Xu Q. Pharmacol. Res. 44 (2001) 135
6. Xu Q., Wang F., Chen J., and Chen T. Eur. J. Pharmacol. 377 (1999) 93
7. Chen Y., Chen T., and Xu Q. J. Pharm. Pharmacol. 55 (2003) 691
8. Yi H., Lu X., Fang F., Wang J., and Xu Q. Int. Immunopharmacol. 8 (2008) 1467
9. Joshua D., Shengmin S., Anthony Y.H., and Yang S. Curr. Drug Metab. 8 (2007) 499
10. Zhu B.T. Curr. Drug Metab. 3 (2002) 321
11. Guo J., Qian F., Li J., Xu Q., and Chen T. Clin. Chem. 53 (2007) 465
12. Guo J., Xu Q., and Chen T. J. Chromatogr. B 805 (2004) 357
13. US Department of Health and Human Services, Food and Drug Administration, and Center for Drug Evaluation and Research (CDER). Guidance for Industry, Bioanalytical Method Validation (2001)