A promising new alternative for the rapid reversal of warfarin coagulopathy in traumatic intracranial hemorrhage

American Journal of Surgery

Volumn 197, Issue 6, 2009, Pages 785-790

  Safaoui, Marian N ^a   Aazami, Roshanak ^a   Hotz, Heidi ^a   Wilson, Matthew T ^a   Margulies, Daniel R ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Factor IX complex; Prothrombin complex concentrate; Traumatic intracranial hemorrhage; Warfarin reversal; Warfarin induced coagulopathy

Indexed keywords

BLOOD CLOTTING FACTOR 9 COMPLEX; VITAMIN K GROUP; WARFARIN;

ADULT; AGED; ALLERGIC REACTION; ARTICLE; BLOOD CLOTTING DISORDER; BRAIN HEMORRHAGE; CLINICAL ARTICLE; FEMALE; HOSPITAL ADMISSION; HUMAN; INTERNATIONAL NORMALIZED RATIO; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RETROSPECTIVE STUDY; THROMBOSIS; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; ANTICOAGULANTS; BLOOD COAGULATION DISORDERS; CEREBRAL HEMORRHAGE, TRAUMATIC; FACTOR IX; FEMALE; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; TIME FACTORS; WARFARIN;

EID: 66149136817     PISSN: 00029610     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjsurg.2008.04.003     Document Type: Article

References (31)

1. Ivascu F.A., Howells G.A., Junn F.S., et al. Rapid warfarin reversal in anticoagulated patients with traumatic intracranial hemorrhage reduces hemorrhage progression and mortality. J Trauma 59 (2005) 1131-1139
2. Boulis N.M., Bobek M.P., Schmaier A., et al. Use of factor IX complex in warfarin-related intracranial hemorrhage. Neurosurgery 45 (1999) 1113-1119
3. Hanley J.P. Warfarin reversal. J Clin Pathol 57 (2004) 1132-1139
4. Baker R.I., Coughlin P.B., Gallus A.S., et al. Warfarin reversal: consensus guidelines, on behalf of the Australasian Society of Thrombosis and Haemostasis. Med J Aust 181 (2004) 492-497
5. Shapiro A.D., Di Paola J., Cohen A., et al. The safety and efficacy of recombinant human blood coagulation factor IX in previously untreated patients with severe or moderately severe hemophilia B. Blood 105 (2005) 518-525
6. Yasaka M., Oomura M., Ikeno K., et al. Effect of prothrombin complex concentrate on INR and blood coagulation system in emergency patients treated with warfarin overdose. Ann Hematol 82 (2003) 121-123
7. Yasaka M., Sakata T., Minematsu K., et al. Correction of INR by prothrombin complex concentrate and vitamin K in patients with warfarin related hemorrhagic complication. Thromb Res 108 (2003) 25-30
8. Preston F.E., Laidlaw S.T., Sampson B., et al. Rapid reversal of oral anticoagulation with warfarin by a prothrombin complex concentrate (Beriplex): efficacy and safety in 42 patients. Br J Haematol 116 (2002) 619-624
9. Cartmill M., Dolan G., Byrne J.L., et al. Prothrombin complex concentrate for oral anticoagulant reversal in neurosurgical emergencies. Br J Neurosurg 14 (2000) 458-461
10. Vigué B., Ract C., Tremey B., et al. Ultra-rapid management of oral anticoagulant therapy-related surgical intracranial hemorrhage. Intensive Care Med 33 (2007) 721-725
11. Aguilar M., Hart R.G., Kase C.S., et al. Treatment of warfarin-associated intracerebral hemorrhage: literature review and expert opinion. Mayo Clin Proc 82 (2007) 82-92
12. Yasaka M., Minematsu K., Naritomi H., et al. Predisposing factors for enlargement of intracerebral hemorrhage in patients treated with warfarin. J Thromb Haemost 89 (2003) 278-283
13. Kessler C.M. Urgent reversal of warfarin with prothrombin complex concentrate: where are the evidence-based data?. J Thromb Haemost 4 (2006) 963-966
14. Lankiewicz M.W., Hays J., Friedman K.D., et al. Urgent reversal of warfarin with prothrombin complex concentrate. J Thromb Haemost 4 (2006) 967-970
15. Lavenne-Pardonge E., Itegwa M.A., Kalaai M., et al. Emergency reversal of oral anticoagulation through PPSB-SD: the fastest procedure in Belgium. Acta Anaesth Belg 57 (2006) 121-125
16. Makris M. Optimization of the prothrombin complex concentrate dose for warfarin reversal. Thromb Res 115 (2005) 451-453
17. van Aart L., Eijkhout H., Kamphuis J.S., et al. Individualized dosing regimen for prothrombin complex concentrate more effective than standard treatment in the reversal of oral anticoagulant therapy: an open, prospective randomized controlled trial. Thromb Res 118 (2006) 313-320
18. Kohler M., Hellstern P., Lechler E., et al. Thromboembolic complications associated with the use of prothrombin complex and factor IX concentrates. J Thromb Haemost 80 (1998) 399-402
19. Kohler M. Thrombogenicity of prothrombin complex concentrates. Thromb Res 95 (1999) S13-S17
20. ®) for rapid reversal of oral anticoagulation. Thromb Res 113 (2004) 371-378
21. Evans G., Luddington R., and Baglin T. Beriplex T/N reverses severe warfarin-induced overanticoagulation immediately and completely in patients presenting with major bleeding. Br J Haematol 115 (2001) 998-1001
22. Lin J., Hanigan W.C., Tarantino M., et al. The use of recombinant activated factor VII to reverse warfarin-induced anticoagulation in patients with hemorrhages in the central nervous system: preliminary findings. J Neurosurg 98 (2003) 737-740
23. Veshchev I., Elran H., and Salame K. Recombinant coagulation factor VIIa for rapid preoperative correction of warfarin-related coagulopathy in patients with acute subdural Hematoma. Med Sci Monit 8 (2002) CS98-CS100
24. Park P., Fewel M.E., Garton H.J., et al. Recombinant activated factor VII for the rapid correction of coagulopathy in nonhemophilic neurosurgical patients. Neurosurgery 53 (2003) 34-39
25. Deveras R.A., and Kessler C.M. Reversal of warfarin-induced excessive anticoagulation with recombinant human factor VIIa concentrate. Ann Intern Med 137 (2002) 884-888
26. Brody D.L., Aiyagari V., Shackleford A.M., et al. Use of recombinant factor VIIa in patients with warfarin-associated intracranial hemorrhage. Neurocrit Care 2 (2005) 263-267
27. Mayer S.A., Brun N.C., Begtrup K., et al. Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 352 (2005) 777-785
28. Bartal C., Freedman J., Bowman K., et al. Coagulopathic patients with traumatic intracranial bleeding: defining the role of recombinant Factor VIIa. J Trauma 63 (2007) 725-732
29. Thompson K.M., Gerlach S.Y., Jorn K.S., et al. Advances in the care of patients with intracerebral hemorrhage. Mayo Clin Proc 82 (2007) 987-990
30. O'Connell K.A., Wood J.J., Wise R.P., et al. Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. JAMA 295 (2006) 293-298
31. Dickneite G. Prothrombin complex concentrate versus recombinant factor VIIa for reversal of coumarin anticoagulation. Thromb Res 119 (2007) 643-651