Serine protease inhibitor 8 is a novel immunohistochemical marker for neuroendocrine tumors of the pancreas

Pancreas

Volumn 38, Issue 4, 2009, Pages 461-467

  De Koning, Pieter J A ^a   Bovenschen, Niels ^a   Broekhuizen, Roel ^a   Lips, Cornelis J M ^a   Kummer, J Alain ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Insulin; Islet cell tumor; Marker; Neuroendocrine; Pancreas; SERPINB8

Indexed keywords

BIOLOGICAL MARKER; CHROMOGRANIN A; GLUCAGON; INSULIN; SERINE PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR 8; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; CALCITONIN; SERPINB8 PROTEIN, HUMAN; TUMOR MARKER;

ADRENAL CORTEX; ARTICLE; CLINICAL ARTICLE; COLON; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; HYPOPHYSIS; IMMUNOHISTOCHEMISTRY; INSULINOMA; MALE; NEUROSECRETORY CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENSITIVITY ANALYSIS; THYROID GLAND; ADULT; AGED; CHILD; CYTOLOGY; METABOLISM; MIDDLE AGED; NEUROENDOCRINE TUMOR; PANCREAS TUMOR; PATHOLOGY; PRESCHOOL CHILD;

ADRENAL CORTEX; ADULT; AGED; CALCITONIN; CHILD; CHILD, PRESCHOOL; CHROMOGRANIN A; COLON; FEMALE; GLUCAGON; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-SECRETING CELLS; MALE; MIDDLE AGED; NEUROENDOCRINE CELLS; NEUROENDOCRINE TUMORS; PANCREATIC NEOPLASMS; PITUITARY GLAND; SERPINS; SYNAPTOPHYSIN; THYROID GLAND; TUMOR MARKERS, BIOLOGICAL;

EID: 66149122661     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e318194fcc2     Document Type: Article

References (24)

1. Barakat MT, Meeran K, Bloom SR. Neuroendocrine tumours. Endocr Relat Cancer. 2004;11(1):1-18.
2. Baudin E, Bidart JM, Bachelot A, et al. Impact of chromogranin A measurement in the work-up of neuroendocrine tumors. Ann Oncol. 2001;12(suppl 2):S79-S82. (Pubitemid 33069692)
3. Steiner DF. The proprotein convertases. Curr Opin Chem Biol. 1998; 2(1):31-39.
4. Thomas G. Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol. 2002;3(10): 753-766.
5. Rouille Y, Duguay SJ, Lund K, et al. Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases. Front Neuroendocrinol. 1995;16(4):322-361.
6. Bird PI. Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins. Immunol Cell Biol. 1999;77(1):47-57.
7. Dahlen JR, Jean F, Thomas G, et al. Inhibition of soluble recombinant furin by human proteinase inhibitor 8. J Biol Chem. 1998;273(4): 1851-1854. (Pubitemid 28069224)
8. Leblond J, Laprise MH, Gaudreau S, et al. The serpin proteinase inhibitor 8: an endogenous furin inhibitor released from human platelets. Thromb Haemost. 2006;95(2):243-252.
9. Silverman GA, Whisstock JC, Askew DJ, et al. Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis. Cell Mol Life Sci. 2004;61(3):301-325.
10. Strik MC, Bladergroen BA, Wouters D, et al. Distribution of the human intracellular serpin protease inhibitor 8 in human tissues. J Histochem Cytochem. 2002;50(11):1443-1454. (Pubitemid 36024891)
11. Kloppel G, Perren A, Heitz PU. The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification. Ann N Y Acad Sci. 2004;1014:13-27. (Pubitemid 38594787)
12. Dahlen JR, Foster DC, Kisiel W. Expression, purification, and inhibitory properties of human proteinase inhibitor 8. Biochemistry. 1997;36(48):14874- 14882. (Pubitemid 27524411)
13. Frankel WL. Update on pancreatic endocrine tumors. Arch Pathol Lab Med. 2006;130(7):963-966.
14. Vortmeyer AO, Huang S, Lubensky I, et al. Non-islet origin of pancreatic islet cell tumors. J Clin Endocrinol Metab. 2004;89(4): 1934-1938. (Pubitemid 38507955)
15. Vinik AI, Moattari AR. Treatment of endocrine tumors of the pancreas. Endocrinol Metab Clin North Am. 1989;18(2):483-518.
16. Nehar D, Lombard-Bohas C, Olivieri S, et al. Interest of chromogranin A for diagnosis and follow-up of endocrine tumours. Clin Endocrinol (Oxf ). 2004;60(5):644-652. (Pubitemid 38669857)
17. Brioschi PA, Bischof P, Delafosse C, et al. Squamous-cell carcinoma antigen (SCC-A) values related to clinical outcome of pre-invasive and invasive cervical carcinoma. Int J Cancer. 1991;47(3):376-379.
18. Molina R, Torres MD, Moragas M, et al. Prognostic significance of SCC antigen in the serum of patients with head and neck cancer. Tumour Biol. 1996;17(2):81-89. (Pubitemid 26077980)
19. Bladergroen BA, Meijer CJ, ten Berge RL, et al. Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system? Blood. 2002;99(1):232-237.
20. van Houdt IS, Oudejans JJ, van den Eertwegh AJ, et al. Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma. Clin Cancer Res. 2005;11(17):6400- 6407.
21. Sun J, Bird CH, Sutton V, et al. A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. J Biol Chem. 1996;271(44): 27802-27809. (Pubitemid 26367355)
22. Strik MC, Wolbink A, Wouters D, et al. Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers. Blood. 2004;103(7): 2710-2717. (Pubitemid 38393029)
23. Sprecher CA, Morgenstern KA, Mathewes S, et al. Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. J Biol Chem. 1995; 270(50):29854-29861. (Pubitemid 26001658)
24. Dahlen JR, Foster DC, Kisiel W. The inhibitory specificity of human proteinase inhibitor 8 is expanded through the use of multiple reactive site residues. Biochem Biophys Res Commun. 1998;244(1):172-177. (Pubitemid 28419919)