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Volumn , Issue 13, 2009, Pages 2055-2058

Photolabile carbonyl protecting group: A new tool for light-controlled release of anticancer agents

Author keywords

Antitumor agents; Drug delivery; Phosphorus; Photolabile groups; Prodrugs; Protecting groups

Indexed keywords


EID: 66149115099     PISSN: 1434193X     EISSN: 10990690     Source Type: Journal    
DOI: 10.1002/ejoc.200900093     Document Type: Article
Times cited : (21)

References (35)
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    • B. A. Chabner, J. M. Collins Eds, J. L. Lippincott, Philadelphia, PA
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  • 4
    • 34249844568 scopus 로고    scopus 로고
    • For recent reviews of CP and related prodrugs, see: a
    • For recent reviews of CP and related prodrugs, see: a) J. Zhang, Q. Tian, S.-F. Zhou, Curr. Drug Ther. 2006, 1,55-84;
    • (2006) Curr. Drug Ther , vol.1 , pp. 55-84
    • Zhang, J.1    Tian, Q.2    Zhou, S.-F.3
  • 16
  • 17
    • 0141538127 scopus 로고    scopus 로고
    • and references cited therein;
    • a) L. F. Tietze, T. Feuerstein, Curr. Pharm. Des. 2003, 9, 2155-2175 and references cited therein;
    • (2003) Curr. Pharm. Des , vol.9 , pp. 2155-2175
    • Tietze, L.F.1    Feuerstein, T.2
  • 24
    • 66149123801 scopus 로고    scopus 로고
    • It is well established that PEG improves the aqueous solubility, circulation half-life, and other pharmacokinetic properties of a drug. It is also known that PEG conjugates (MW > 10 K Dalton) have higher accumulation in tumors than in normal tissues as a result of the enhanced permeation and retention effect associated with macromolecules;
    • a) It is well established that PEG improves the aqueous solubility, circulation half-life, and other pharmacokinetic properties of a drug. It is also known that PEG conjugates (MW > 10 K Dalton) have higher accumulation in tumors than in normal tissues as a result of the "enhanced permeation and retention effect" associated with macromolecules;
  • 26
    • 66149093957 scopus 로고    scopus 로고
    • 31P NMR spectra were recorded at 161.97 MHz and chemical shifts were measured relative to external H3PO4 (85 %) in a coaxial capillary tube.
    • 31P NMR spectra were recorded at 161.97 MHz and chemical shifts were measured relative to external H3PO4 (85 %) in a coaxial capillary tube.
  • 29
    • 66149100553 scopus 로고    scopus 로고
    • The chemical shifts of the intermediates are not identical to the values reported by others,[10,12] owing to the sensitivity of 31P NMR chemical shifts to the different experimental conditions. However, the growth of the signals and the disappearance pattern support the assignments.
    • The chemical shifts of the intermediates are not identical to the values reported by others,[10,12] owing to the sensitivity of 31P NMR chemical shifts to the different experimental conditions. However, the growth of the signals and the disappearance pattern support the assignments.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.