Small intestinal MUC2 synthesis in human preterm infants

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 296, Issue 5, 2009, Pages

  Schaart, Maaike W ^a   De Bruijn, Adrianus C J M ^a   Schierbeek, Henk ^a   Tibboel, Dick ^a   Renes, Ingrid B ^a   Van Goudoever, Johannes B ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

Mucin 2; Small intestine; Threonine

Indexed keywords

MUCIN 2; THREONINE; CARBON; MUC2 PROTEIN, HUMAN;

ARTICLE; CALCULATION; CLINICAL ARTICLE; FRACTIONAL SYNTHETIC RATE; HUMAN; INFANT; INTESTINE FLUID; INTESTINE MUCOSA PERMEABILITY; MALE; NECROTIZING ENTEROCOLITIS; NEWBORN; PREMATURITY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SMALL INTESTINE; BIOSYNTHESIS; ENTERIC FEEDING; GESTATIONAL AGE; ILEOSTOMY; INTRAVENOUS DRUG ADMINISTRATION; JEJUNOSTOMY; KINETICS; METABOLISM;

CARBON ISOTOPES; ENTERAL NUTRITION; ENTEROCOLITIS, NECROTIZING; GESTATIONAL AGE; HUMANS; ILEOSTOMY; INFANT, NEWBORN; INFANT, PREMATURE; INFUSIONS, INTRAVENOUS; INTESTINE, SMALL; JEJUNOSTOMY; KINETICS; MALE; MUCIN-2; THREONINE;

EID: 66149097397     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.90444.2008     Document Type: Article

References (36)

1. Barle H, Hammarqvist F, Westman B, Klaude M, Rooyackers O, Garlick PJ, Wernerman J. Synthesis rates of total liver protein and albumin are both increased in patients with an acute inflammatory response. Clin Sci (Lond) 110: 93-99, 2006.
2. Bertolo RF, Chen CZ, Law G, Pencharz PB, Ball RO. Threonine requirement of neonatal piglets receiving total parenteral nutrition is considerably lower than that of piglets receiving an identical diet intragastrically. J Nutr 128: 1752-1759, 1998.
3. Burrin DG, Stoll B, Chang X, Van Goudoever JB, Fujii H, Hutson SM, Reeds PJ. Parenteral nutrition results in impaired lactose digestion and hexose absorption when enteral feeding is initiated in infant pigs. Am J Clin Nutr 78: 461-470, 2003.
4. Burrin DG, Stoll B, Jiang R, Chang X, Hartmann B, Holst JJ, Greeley GH Jr, Reeds PJ. Minimal enteral nutrient requirements for intestinal growth in neonatal piglets: how much is enough? Am J Clin Nutr 71: 1603-1610, 2000.
5. Caplan MS, Jilling T. New concepts in necrotizing enterocolitis. Curr Opin Pediatr 13: 111-115, 2001.
6. Ebner S, Schoknecht P, Reeds P, Burrin D. Growth and metabolism of gastrointestinal and skeletal muscle tissues in protein-malnourished neonatal pigs. Am J Physiol Regul Integr Comp Physiol 266: R1736-R1743, 1994.
7. Edelstone DI, Holzman IR. Oxygen consumption by the gastrointestinal tract and liver in conscious newborn lambs. Am J Physiol Gastrointest Liver Physiol 240: G297-G304, 1981.
8. Faure M, Moennoz D, Montigon F, Fay LB, Breuille D, Finot PA, Ballevre O, Boza J. Development of a rapid and convenient method to purify mucins and determine their in vivo synthesis rate in rats. Anal Biochem 307: 244-251, 2002.
9. Forstner JF, Forstner GG. Gastrointestinal mucus In: Physiology of the Gastrointestinal Tract, edited by Johnson L. New York: Raven, 1994, p. 1255-1283.
10. Francois C, Marshall RD, Neuberger A. Carbohydrates in protein. 4. The determination of mannose in hen's-egg albumin by radioisotope dilution. Biochem J 83: 335-341, 1962.
11. Iiboshi Y, Nezu R, Kennedy M, Fujii M, Wasa M, Fukuzawa M, Kamata S, Takagi Y, Okada A. Total parenteral nutrition decreases luminal mucous gel and increases permeability of small intestine. JPEN J Parenter Enteral Nutr 18: 346-350, 1994.
12. Kansagra K, Stoll B, Rognerud C, Niinikoski H, Ou CN, Harvey R, Burrin D. Total parenteral nutrition adversely affects gut barrier function in neonatal piglets. Am J Physiol Gastrointest Liver Physiol 285: G1162-G1170, 2003.
13. Konat G, Offner H, Mellah J. Improved method for staining of glycoproteins in polyacrylamide gels. Experientia 40: 303-304, 1984.
14. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
15. Lobley GE, Milne V, Lovie JM, Reeds PJ, Pennie K. Whole body and tissue protein synthesis in cattle. Br J Nutr 43: 491-502, 1980.
16. Maenz DD, Patience JF. L-threonine transport in pig jejunal brush border membrane vesicles. Functional characterization of the unique system B in the intestinal epithelium. J Biol Chem 267: 22079-22086, 1992.
17. McNurlan MA, Essen P, Milne E, Vinnars E, Garlick PJ, Wernerman J. Temporal responses of protein synthesis in human skeletal muscle to feeding. Br J Nutr 69: 117-126, 1993.
18. McNurlan MA, Garlick PJ. Contribution of rat liver and gastrointestinal tract to whole-body protein synthesis in the rat. Biochem J 186: 381-383, 1980.
19. Nakshabendi IM, McKee R, Downie S, Russell RI, Rennie MJ. Rates of small intestinal mucosal protein synthesis in human jejunum and ileum. Am J Physiol Endocrinol Metab 277: E1028-E1031, 1999.
20. Reeds PJ, Burrin DG, Jahoor F, Wykes L, Henry J, Frazer EM. Enteral glutamate is almost completely metabolized in first pass by the gastrointestinal tract of infant pigs. Am J Physiol Endocrinol Metab 270: E413-E418, 1996.
21. Reeds PJ, Burrin DG, Stoll B, Jahoor F, Wykes L, Henry J, Frazer ME. Enteral glutamate is the preferential source for mucosal glutathione synthesis in fed piglets. Am J Physiol Endocrinol Metab 273: E408-E415, 1997.
22. 13C]leucine infusion. Am J Physiol Endocrinol Metab 278: E634-E638, 2000.
23. Rossi TM, Lee PC, Young C, Tjota A. Small intestinal mucosa changes, including epithelial cell proliferative activity, of children receiving total parenteral nutrition (TPN). Dig Dis Sci 38: 1608-1613, 1993.
24. Schaart MW, Schierbeek H, de Bruijn AC, Tibboel D, van Goudoever JB, Renes IB. A novel method to determine small intestinal barrier function in human neonates in vivo. Gut 55: 1366-1367, 2006.
25. Schaart MW, Schierbeek H, van der Schoor SR, Stoll B, Burrin DG, Reeds PJ, van Goudoever JB. Threonine utilization is high in the intestine of piglets. J Nutr 135: 765-770, 2005.
26. Stoll B, Burrin DG, Henry J, Yu H, Jahoor F, Reeds PJ. Substrate oxidation by the portal drained viscera of fed piglets. Am J Physiol Endocrinol Metab 277: E168-E175, 1999.
27. Stoll B, Burrin DG, Henry JF, Jahoor F, Reeds PJ. Dietary and systemic phenylalanine utilization for mucosal and hepatic constitutive protein synthesis in pigs. Am J Physiol Gastrointest Liver Physiol 276: G49-G57, 1999.
28. Stoll B, Henry J, Reeds PJ, Yu H, Jahoor F, Burrin DG. Catabolism dominates the first-pass intestinal metabolism of dietary essential amino acids in milk protein-fed piglets. J Nutr 128: 606-614, 1998.
29. Strous GJ, Dekker J. Mucin-type glycoproteins. Crit Rev Biochem Mol Biol 27: 57-92, 1992.
30. Tytgat KM, Buller HA, Opdam FJ, Kim YS, Einerhand AW, Dekker J. Biosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin. Gastroenterology 107: 1352-1363, 1994.
31. van der Schoor SR, van Goudoever JB, Stoll B, Henry JF, Rosenberger JR, Burrin DG, Reeds PJ. The pattern of intestinal substrate oxidation is altered by protein restriction in pigs. Gastroenterology 121: 1167-1175, 2001.
32. van Goudoever JB, Stoll B, Henry JF, Burrin DG, Reeds PJ. Adaptive regulation of intestinal lysine metabolism. Proc Natl Acad Sci USA 97: 11620-11625, 2000.
33. Van Klinken BJ, Dekker J, Buller HA, Einerhand AW. Mucin gene structure and expression: protection vs. adhesion. Am J Physiol Gastrointest Liver Physiol 269: G613-G627, 1995.
34. Volpi E, Sheffield-Moore M, Rasmussen BB, Wolfe RR. Basal muscle amino acid kinetics and protein synthesis in healthy young and older men. JAMA 286: 1206-1212, 2001.
35. Walker WA. Development of the intestinal mucosal barrier. J Pediatr Gastroenterol Nutr 34, Suppl 1: S33-S39, 2002.
36. Yu YM, Burke JF, Vogt JA, Chambers L, Young VR. Splanchnic and whole body L-[1-13C,15N]leucine kinetics in relation to enteral and parenteral amino acid supply. Am J Physiol Endocrinol Metab 262: E687-E694, 1992.