Non-A type nucleophosmin 1 gene mutation predicts poor clinical outcome in de novo adult acute myeloid leukemia: Differential clinical importance of NPM1 mutation according to subtype

International Journal of Hematology

Volumn 90, Issue 1, 2009, Pages 1-5

  Koh, Youngil ^a   Park, Juwon ^b   Bae, Eun Kyung ^c   Ahn, Kwang Sung ^b   Kim, Inho ^a,b   Bang, Soo Mee ^d   Lee, Jae Hoon ^e   Yoon, Sung Soo ^a   Lee, Dong Soon ^a   Lee, Young Yiul ^f   Park, Seonyang ^a,b   Kim, Byoung Kook ^a,b  

^a Seoul National University Hospital   (South Korea)

^b Seoul National University   (South Korea)

^c Hanyang University   (South Korea)

^d Seoul National University Bundang Hospital   (South Korea)

^e Gachon University   (South Korea)

^f Hanyang University College of Medicine   (South Korea)

Author keywords

AML; NPM1; Prognosis

Indexed keywords

CYTARABINE; DAUNORUBICIN; FLT3 LIGAND; GENOMIC DNA; IDARUBICIN; NUCLEOPHOSMIN;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD SAMPLING; CANCER CHEMOTHERAPY; CONTROLLED STUDY; FEMALE; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; MUTATION; NUCLEAR PROTEINS; RETROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 66149093027     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12185-009-0350-1     Document Type: Article

References (17)

1. S Schnittger C Schoch W Kern C Mecucci C Tschulik MF Martelli, et al. 2005 Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype Blood 106 12 3733 3739 10.1182/blood-2005-06-2248 16076867 10.1182/blood-2005-06-2248 1:CAS:528:DC%2BD2MXht12ksbjJ (Pubitemid 41739006)
2. B Falini I Nicoletti MF Martelli C Mecucci 2007 Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features Blood 109 3 874 885 10.1182/blood-2006-07-012252 17008539 10.1182/blood-2006-07-012252 1:CAS:528:DC%2BD2sXjtFersLY%3D (Pubitemid 46220630)
3. RG Verhaak CS Goudswaard W van Putten MA Bijl MA Sanders W Hugens, et al. 2005 Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance Blood 106 12 3747 3754 10.1182/blood-2005-05-2168 16109776 10.1182/blood-2005-05-2168 1:CAS:528:DC%2BD2MXht12ksbnM (Pubitemid 41739008)
4. B Falini N Bolli J Shan MP Martelli A Liso A Pucciarini, et al. 2006 Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML Blood 107 11 4514 4523 10.1182/blood-2005-11-4745 16455950 10.1182/blood-2005-11-4745 1:CAS:528:DC%2BD28Xlt1Cgtrg%3D (Pubitemid 43801380)
5. AS Pitiot I Santamaria O Garcia-Suarez I Centeno A Astudillo C Rayon, et al. 2007 A new type of NPM1 gene mutation in AML leading to a C-terminal truncated protein Leukemia 21 7 1564 1566 10.1038/sj.leu.2404679 17410190 10.1038/sj.leu.2404679 1:CAS:528:DC%2BD2sXms1Wnu78%3D (Pubitemid 46965301)
6. K Wheatley AK Burnett AH Goldstone RG Gray IM Hann CJ Harrison, et al. 1999 A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial. United Kingdom Medical Research Council's Adult and Childhood Leukaemia Working Parties Br J Haematol 107 1 69 79 10.1046/j.1365-2141.1999.01684.x 10520026 10.1046/j.1365-2141.1999.01684.x 1:STN:280:DyaK1MvltV2ntw%3D%3D (Pubitemid 29500811)
7. ML Slovak KJ Kopecky PA Cassileth DH Harrington KS Theil A Mohamed, et al. 2000 Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study Blood 96 13 4075 4083 11110676 1:CAS:528:DC%2BD3cXosl2hsbo%3D
8. D Grimwade H Walker G Harrison F Oliver S Chatters CJ Harrison, et al. 2001 The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial Blood 98 5 1312 1320 10.1182/blood.V98.5.1312 11520776 10.1182/blood.V98.5.1312 1:CAS:528: DC%2BD3MXmvFGjtrw%3D
9. RH Don PT Cox BJ Wainwright K Baker JS Mattick 1991 Touchdown' PCR to circumvent spurious priming during gene amplification Nucleic Acids Res 19 14 4008 10.1093/nar/19.14.4008 1861999 10.1093/nar/19.14.4008 1:CAS:528: DyaK3MXmtVShu70%3D
10. B Falini C Mecucci E Tiacci M Alcalay R Rosati L Pasqualucci, et al. 2005 Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype N Engl J Med 352 3 254 266 10.1056/NEJMoa041974 15659725 10.1056/NEJMoa041974 1:CAS:528:DC%2BD2MXmslShug%3D%3D (Pubitemid 40110814)
11. S Kurki K Peltonen M Laiho 2004 Nucleophosmin, HDM2 and p53: players in UV damage incited nucleolar stress response Cell Cycle 3 8 976 979 15254398 1:CAS:528:DC%2BD2MXkvFCit7Y%3D
12. CJ Sherr 2006 Divorcing ARF and p53: an unsettled case Nat Rev Cancer 6 9 663 673 10.1038/nrc1954 16915296 10.1038/nrc1954 1:CAS:528:DC%2BD28XosVOmsLk%3D (Pubitemid 44285999)
13. E Colombo JC Marine D Danovi B Falini PG Pelicci 2002 Nucleophosmin regulates the stability and transcriptional activity of p53 Nat Cell Biol 4 7 529 533 10.1038/ncb814 12080348 10.1038/ncb814 1:CAS:528:DC%2BD38XmtVWksbc%3D (Pubitemid 34752440)
14. T Suzuki H Kiyoi K Ozeki A Tomita S Yamaji R Suzuki, et al. 2005 Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia Blood 106 8 2854 2861 10.1182/blood-2005-04-1733 15994285 10.1182/blood-2005-04-1733 1:CAS:528:DC%2BD2MXhtFantbbE (Pubitemid 41510764)
15. Y Yamamoto H Kiyoi Y Nakano R Suzuki Y Kodera S Miyawaki, et al. 2001 Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies Blood 97 8 2434 2439 10.1182/blood.V97.8.2434 11290608 10.1182/blood.V97.8.2434 1:CAS:528:DC%2BD3MXivFOgtbk%3D (Pubitemid 32291491)
16. HJ Kang SH Hong IH Kim BK Park KS Han HI Cho, et al. 2005 Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia Leuk Res 29 6 617 623 10.1016/j.leukres.2004.11.006 15863200 10.1016/j.leukres.2004.11.006 1:CAS:528:DC%2BD2MXjs1Klsbk%3D (Pubitemid 40603560)
17. KW Lee IS Choi EY Roh DY Kim T Yun DS Lee, et al. 2004 Adult patients with t(8;21) acute myeloid leukemia had no superior treatment outcome to those without t(8;21): a single institution's experience Ann Hematol 83 4 218 224 10.1007/s00277-003-0811-1 14628154 10.1007/s00277-003-0811-1 1:CAS:528:DC%2BD2cXitVOitLs%3D (Pubitemid 38443506)