A subnormal peak cortisol response to stimulation testing does not predict a subnormal cortisol production rate

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 5, 2009, Pages 1757-1760

  Paisley, A N ^a   Rowles, S V ^a   Brandon, D ^b   Trainer, P J ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE; INSULIN; ANTIDIABETIC AGENT; DIAGNOSTIC AGENT;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOCRINE FUNCTION TEST; FEMALE; HORMONE RESPONSE; HORMONE SUBSTITUTION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; HYDROCORTISONE URINE LEVEL; HYPOGLYCEMIA; HYPOPHYSIS DISEASE; MALE; PRIORITY JOURNAL; BIOSYNTHESIS; BLOOD; CHEMICALLY INDUCED DISORDER; GLUCOSE BLOOD LEVEL; KINETICS; MASS FRAGMENTOGRAPHY; METABOLISM; MIDDLE AGED;

ADULT; BLOOD GLUCOSE; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HORMONE REPLACEMENT THERAPY; HUMANS; HYDROCORTISONE; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; KINETICS; MALE; MIDDLE AGED; PITUITARY DISEASES;

EID: 66149088875     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-2392     Document Type: Article

References (21)

1. Bates AS, Van't Hoff W, Jones PJ, Clayton RN 1996 The effect of hypopituitarism on life expectancy. J Clin Endocrinol Metab 81:1169-1172
2. Greenspan FS, Gardner DG 2001 Basic, clinical endocrinology. New York: The McGraw Hill Companies
3. Plumpton FS, Besser GM, Cole PV 1969 Corticosteroid treatment and surgery. 1. An investigation of the indications for steroid cover. Anaesthesia 24:3-11
4. Wass J, Shalet SM 2002 Pituitary assessment strategy. Oxford textbook of endocrinology and diabetes. New York: Oxford University Press; 129
5. Cope CL, Black EG 1958 The behaviour of 14c-cortisol and estimation of cortisol production rate in man. Clin Sci (Lond) 17:147-163
6. Fukushima DK, Gallagher TF, Greenberg W, Pearson OH 1960 Studies with an adrenal inhibitor in adrenal carcinoma. J Clin Endocrinol Metab 20:1234-1245
7. Brooks RV, Dupre J, Gogate AN, Mills IH, Prunty FT 1963 Appraisal of adrenocortical hyperfunction: patients with Cushing's syndrome or "non-endocrine" tumors. J Clin Endocrinol Metab 23:725-736
8. Peterson RE, Wyngaarden JB 1956 The miscible pool and turnover rate of hydrocortisone in man. J Clin Invest 35:552-561
9. Tait JF, Little B, Tait SA, Flood C 1962 The metabolic clearance rate of aldosterone in pregnant and nonpregnant subjects estimated by both single-injection and constant-infusion methods. J Clin Invest 41:2093-2100
10. Zumoff B, Fukushima DK, Hellman L 1974 Intercomparison of four methods for measuring cortisol production. J Clin Endocrinol Metab 38:169-175
11. Esteban NV, Loughlin T, Yergey AL, Zawadzki JK, Booth JD, Winterer JC, Loriaux DL 1991 Daily cortisol production rate in man determined by stable isotope dilution/mass spectrometry. J Clin Endocrinol Metab 72:39-45 (Pubitemid 21921653)
12. Gallagher TF, Fukushima DK, Hellman L 1970 The clarification of discrepancies in cortisol secretion rate. J Clin Endocrinol Metab 31:625-631
13. Agha A, Liew A, Finucane F, Baker L, O'Kelly P, Tormey W, Thompson CJ 2004 Conventional glucocorticoid replacement overtreats adult hypopituitary patients with partial ACTH deficiency. Clin Endocrinol (Oxf) 60:688-693 (Pubitemid 38788075)
14. Samuels MH, Brandon DD, Isabelle LM, Cook DM, Graham KE, Purnell JQ, Loriaux DL 2000 Cortisol production rates in subjects with suspected Cushing's syndrome: assessment by stable isotope dilution methodology and comparison to other diagnostic methods. J Clin Endocrinol Metab 85:22-28 (Pubitemid 32268784)
15. Brandon DD, Isabelle LM, Samuels MH, Kendall JW, Loriaux DL 1999 Cortisol production rate measurement by stable isotope dilution using gas chromatography-negative ion chemical ionization mass spectrometry. Steroids 64:372-378 (Pubitemid 29340520)
16. Filipsson H, Monson JP, Koltowska-Haggstrom M, Mattsson A, Johannsson G 2006 The impact of glucocorticoid replacement regimens on metabolic outcome and comorbidity in hypopituitary patients. J Clin Endocrinol Metab 91:3954-3961 (Pubitemid 44536870)
17. Purnell JQ, Brandon DD, Isabelle LM, Loriaux DL, Samuels MH 2004 Association of 24-hour cortisol production rates, cortisol-binding globulin, and plasma-free cortisol levels with body composition, leptin levels, and aging in adult men and women. J Clin Endocrinol Metab 89:281-287 (Pubitemid 38183894)
18. Stewart PM, Boulton A, Kumar S, Clark PM, Shackleton CH 1999 Cortisol metabolism in human obesity: impaired cortisone→cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab 84:1022-1027 (Pubitemid 29138237)
19. Andrew R, Phillips DI, Walker BR 1998 Obesity and gender influence cortisol secretion and metabolism in man. J Clin Endocrinol Metab 83:1806-1809
20. Mah PM, Jenkins RC, Rostami-Hodjegan A, Newell-Price J, Doane A, Ibbotson V, Tucker GT, Ross RJ 2004 Weight-related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency. Clin Endocrinol (Oxf) 61:367-375 (Pubitemid 39287067)
21. Cope CL, Black EG 1959 The reliability of some adrenal function tests. Br Med J 2:1117-1122