Genetic and Environmental Causes of Individual Differences in Thyroid Size: A Study of Healthy Danish Twins

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 5, 2004, Pages 2071-2077

  Hansen, Pia Skov ^a,b   Brix, Thomas Heiberg ^a   Bennedbæk, Finn Noe ^a   Bonnema, Steen Joop ^a   Kyvik, Kirsten Ohm ^b   Hegedüs, Laszlo ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHYROID AGENT; IODINE; THYROTROPIN;

ADULT; AGE; ARTICLE; BODY MASS; CIGARETTE SMOKING; CORRELATION FUNCTION; DENMARK; DIETARY INTAKE; DIZYGOTIC TWINS; ENVIRONMENTAL FACTOR; FEMALE; GENDER; GENETIC MODEL; GENETICS; HUMAN; HUMAN EXPERIMENT; IODINE DEFICIENCY; MALE; MONOZYGOTIC TWINS; NORMAL HUMAN; PARITY; PRIORITY JOURNAL; REGISTER; THYROID WEIGHT; THYROTROPIN BLOOD LEVEL; TWINS; ULTRASOUND;

ADOLESCENT; ADULT; BIOMETRY; ENVIRONMENT; FEMALE; HUMANS; MALE; MIDDLE AGED; MODELS, ANATOMIC; ORGAN SIZE; REFERENCE VALUES; THYROID GLAND; TWINS;

EID: 2442526246     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-031999     Document Type: Article

References (42)

1. Hegedüs L 1990 Thyroid size determined by ultrasound. Influence of physiological factors and non-thyroidal disease. Dan Med Bull 37:249-263
2. Knudsen N, Laurberg P, Perrild H, Bülow I, Ovesen L, Jørgensen T 2002 Risk factors for goiter and thyroid nodules. Thyroid 12:879-888
3. Knudsen N, Bülow I, Jørgensen T, Laurberg P, Ovesen L, Perrild H 2000 Goitre prevalence and thyroid abnormalities at ultrasonography: a comparative epidemiological study in two regions with slightly different iodine status. Clin Endocrinol (Oxf) 53:479-485
4. Pedersen KM, Laurberg P, Nøhr S, Jørgensen A, Andersen S 1999 Iodine in drinking water varies by more than 100-fold in Denmark. Importance for iodine content of infant formulas. Eur J Endocrinol 140:400-403
5. Gomez JM, Maravall FJ, Gomez N, Guma A, Soler J 2000 Determinants of thyroid volume as measured by ultrasonography in healthy adults randomly selected. Clin Endocrinol (Oxf) 53:629-634
6. Wesche MF, Wiersinga WM, Smits NJ 1998 Lean body mass as a determinant of thyroid size. Clin Endocrinol (Oxf) 48:701-706
7. Barrere X, Valeix P, Preziosi P, Bensimon M, Pelletier B, Galan P, Hercberg S 2000 Determinants of thyroid volume in healthy French adults participating in the SU.VI.MAX cohort. Clin Endocrinol (Oxf) 52:273-278
8. Rasmussen NG, Hornnes PJ, Hegedüs L 1989 Ultrasonographically determined thyroid size in pregnancy and post partum: the goitrogenic effect of pregnancy. Am J Obstet Gynecol 160:1216-1220
9. Hegedüs L, Karstrup S, Veiergang D, Jacobsen B, Skovsted L, Feldt-Rasmussen U 1985 High frequency of goitre in cigarette smokers. Clin Endocrinol (Oxf) 22:287-292
10. Knudsen N, Bülow I, Laurberg P, Ovesen L, Perrild H, Jørgensen T 2002 Association of tobacco smoking with goiter in a low-iodine-intake area. Arch Intern Med 162:439-443
11. Berghout A, Wiersinga WM, Smits NJ, Touber JL 1987 Determinants of thyroid volume as measured by ultrasonography in healthy adults in a non-iodine deficient area. Clin Endocrinol (Oxf) 26:273-280
12. Brix TH, Kyvik KO, Hegedüs L 1999 Major role of genes in the etiology of simple goiter in females: a population-based twin study. J Clin Endocrinol Metab 84:3071-3075
13. Hegedüs L 2001 Thyroid ultrasound. Endocrinol Metab Clin North Am 30:339-360
14. Skytthe A, Kyvik K, Holm NV, Vaupel JW, Christensen K 2002 The Danish Twin Registry: 127 birth cohorts of twins. Twin Res 5:352-357
15. Delange F 1994 The disorders induced by iodine deficiency. Thyroid 4:107-128
16. Gutekunst R, Becker W, Hehrmann R, Olbricht T, Pfannenstiel P 1988 Ultrasonic diagnosis of the thyroid gland. Dtsch Med Wochenschr 113:1109-1112
17. Hegedüs L, Perrild H, Poulsen LR, Andersen JR, Holm B, Schnohr P, Jensen G, Hansen JM 1983 The determination of thyroid volume by ultrasound and its relationship to body weight, age, and sex in normal subjects. J Clin Endocrinol Metab 56:260-263
18. PerkinElmer 1997 User's manual. Foster City, CA: PerkinElmer
19. Brunner E 1991 A nonparametric estimator of the shift effect for repeated observations. Biometrics 47:1149-1153
20. Neale MC, Maes HH 2002 Methodology for genetic studies of twins and families. Dordrecht: Kluwer
21. Boomsma D, Busjahn A, Peltonen L 2002 Classical twin studies and beyond. Nat Rev Genet 3:872-882
22. Evans DM, Gillespie NA, Martin NG 2002 Biometrical genetics. Biol Psychol 61:33-51
23. Rijsdijk FV, Sham PC 2002 Analytic approaches to twin data using structural equation models. Brief Bioinform 3:119-133
24. Devore JL 1987 Probability and statistics for engineering and the sciences. Monterey: Brooks/Cole; 322-367
25. Stata Corp. 2001 Stata statistical software: release 7.0. College Station: Stata Corp.
26. Neale MC, Boker SM, Xie G, Maes HH 2002 Mx: statistical modeling, 6th Ed. Richmond: Virginia Conunonwealth University
27. Gutekunst R, Smolarek H, Hasenpusch U, Stubbe P, Friedrich HJ, Wood WG, Scriba PC 1986 Goitre epidemiology: thyroid volume, iodine excretion, thyroglobulin and thyrotropin in Germany and Sweden. Acta Endocrinol (Copenh) 112:494-501
28. Jarløv AE, Hegedüs L, Gjorup T, Hansen JM 1991 Observer variation in the clinical assessment of the thyroid gland. J Intern Med 229:159-161
29. Langer P 1999 Minireview: discussion about the limit between normal thyroid goiter. Endocr Regul 33:39-45
30. Langer P, Tajtakova M, Bohov P, Klimes I 1999 Possible role of genetic factors in thyroid growth rate and in the assessment of upper limit of normal thyroid volume in iodine-replete adolescents. Thyroid 9:557-562
31. Hansen PS, Brix TH, Sørensen TIA, Kyvik KO, Hegedüs L 2004 Major genetic influence on the regulation of the pituitary-thyroid axis. A study of healthy Danish twins. J Clin Endocrinol Metab 89:1181-1187
32. Vassart G, Dumont JE 1992 The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev 13:596-611
33. Dumont JE, Jauniaux JC, Roger PP 1989 The cyclic AMP-mediated stimulation of cell proliferation. Trends Biochem Sci 14:67-71
34. Dumont JE, Maenhaut C, Lamy F, Pirson I, Clement S, Roger PP 2003 Growth and proliferation of the thyroid cell in normal physiology and in disease. Ann Endocrinol (Paris) 64:10-11
35. Maes HH, Neale MC, Eaves LJ 1997 Genetic and environmental factors in relative body weight and human adiposity. Behav Genet 27:325-351
36. Arden NK, Spector TD 1997 Genetic influences on muscle strength, lean body mass, and bone mineral density: a twin study. J Bone Miner Res 12:2076-2081
37. Hegedüs L, Rasmussen N, Knudsen N 1987 Seasonal variation in thyroid size in healthy males. Horm Metab Res 19:391-392
38. Bertelsen JB, Hegedüs L 1994 Cigarette smoking and the thyroid. Thyroid 4:327-331
39. Knudsen N, Büllow I, Laurberg P, Ovesen L, Perrild H, Jørgensen T 2002 Parity is associated with increased thyroid volume solely among smokers in an area with moderate to mild iodine deficiency. Eur J Endocrinol 146:39-43
40. Hegedüs L, Karstrup S, Rasmussen N 1986 Evidence of cyclic alterations of thyroid size during the menstrual cycle in healthy women. Am J Obstet Gynecol 155:142-145
41. Hopper JL 1993 Variance components for statistical genetics: applications in medical research to characteristics related to human diseases and health. Stat Methods Med Res 2:199-223
42. Rietveld MJ, Posthuma D, Dolan CV, Boomsma DL 2003 ADHD: sibling interaction or dominance: an evaluation of statistical power. Behav Genet 33:247-255