Nanoscale probing reveals that reduced stiffness of clots from fibrinogen lacking 42 N-terminal Bβ-chain residues is due to the formation of abnormal oligomers

Biophysical Journal

Volumn 96, Issue 6, 2009, Pages 2415-2427

  Abou Saleh, Radwa H ^a,b   Connell, Simon D ^a   Harrand, Robert ^a   Ajjan, Ramzi A ^a   Mosesson, Michael W ^c   Smith, D Alastair M ^a   Grant, Peter J ^a   Ariëns, Robert A S ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b Mansoura University   (Egypt)

^c BLOOD RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DES BBETA 1 42 FIBRIN; FIBRIN; FIBRINOGEN; OLIGOMER; SNAKE VENOM; UNCLASSIFIED DRUG; THROMBIN;

AMINO TERMINAL SEQUENCE; ARTICLE; ATOMIC FORCE MICROSCOPY; BETA CHAIN; BLOOD CLOTTING; CONTROLLED STUDY; ELASTICITY; NANOANALYSIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERIZATION; PROTEIN FUNCTION; RIGIDITY; STRUCTURE ANALYSIS; BINDING SITE; CHEMISTRY; HUMAN; METABOLISM; PROTEIN MULTIMERIZATION; SPECTROSCOPY;

CROTALUS ATROX;

BINDING SITES; ELASTICITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FIBRINOGEN; HUMANS; MICROSCOPY, ATOMIC FORCE; PROTEIN MULTIMERIZATION; SPECTRUM ANALYSIS; THROMBIN;

EID: 66149085279     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2008.12.3913     Document Type: Article

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