Breakdown kinetics of C-hydroxymethyl β-dicarbonyl derivatives of carbon acids: Implications in the bioconversion rate of C-phosphoryloxymethyl prodrugs of carbon acids

Journal of Pharmaceutical Sciences

Volumn 98, Issue 5, 2009, Pages 1804-1812

  Dhareshwar, Sundeep S ^a,b   Stella, Valentino J ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Carbon carbon bond break; Dehydroxymethylation; pH rate profile; pKa; dicarbonyl carbon acids

Indexed keywords

C HYDROXYMETHYL BETA DICARBONYL DERIVATIVE; C PHOSPHORYLOXYMETHYL; CARBONYL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG HALF LIFE; DRUG METABOLISM; DRUG STRUCTURE; PH MEASUREMENT; TEMPERATURE MEASUREMENT;

EID: 65949124876     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21540     Document Type: Article

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