Patterns of failure in children with medulloblastoma: Effects of preirradiation chemotherapy

International Journal of Radiation Oncology Biology Physics

Volumn 39, Issue 1, 1997, Pages 15-24

  Hartsell, William F ^a,b,c   Gajjar, Amar ^a,b   Heideman, Richard L ^a,b   Langston, James A ^a,b   Sanford, Robert A ^b   Walter, Andrew ^a   Jones, Dana ^a   Chen, Gang ^a   Kun, Larry E ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c ADVOCATE LUTHERAN GENERAL HOSPITAL   (United States)

Author keywords

Medulloblastoma; Patterns of failure; Preirradiation chemotherapy

Indexed keywords

CARBOPLATIN; CYCLOPHOSPHAMIDE; ETOPOSIDE; VINCRISTINE;

ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; CHILD; CLINICAL FEATURE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MEDULLOBLASTOMA; NERVE FIBER TRANSPORT; NUCLEAR MAGNETIC RESONANCE IMAGING; POSTERIOR FOSSA; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RISK ASSESSMENT; SURVIVAL RATE; TREATMENT FAILURE;

ADOLESCENT; AGE FACTORS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CEREBELLAR NEOPLASMS; CHILD; CHILD, PRESCHOOL; COMBINED MODALITY THERAPY; CRANIAL IRRADIATION; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; HUMANS; INFANT; INFANT, NEWBORN; MEDULLOBLASTOMA; TREATMENT FAILURE;

EID: 0030846771     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(97)00136-3     Document Type: Article

References (34)

1. Albright, A. L.; Wisoff, J. H.; Zeltzer, P. M.; Boyett, J. M.; Rorke, L. B.; Stanley, P. Effects of medulloblastoma resections on outcome in children: A report from the Children's Cancer Group. Neurosurgery 38:265-271; 1996.
2. Attard-Montalto, S.; Plowman, N.; Breatnach, F.; Saha, V.; Eden, O. B. Is there a danger in delaying radiotherapy in childhood medulloblastoma? Br. J. Radiol. 66:807-813; 1993.
3. Bailey, C. C.; Gnekow, A.; Wellek, S.; Jones, M.; Round, C.; Brown, J.; Phillips, A.; Neihardt, M. K. Prospective randomized trial of chemotherapy given before radiotherapy in childhood medulloblastoma. International Society of Paediatric Oncology (SIOP) and the (German) Society of Paediatric Oncology (GPO): SIOP II. Med. Pediatr. Oncol. 25:166-178; 1995.
4. Baram, T. Z.; van Eys, J.; Dowell, R. E.; Cangir, A.; Pack, B.; Bruner, J. M. Survival and neurologic outcome of infants with medulloblastoma treated with surgery and MOPP chemotherapy. Cancer 60:173-177; 1987.
5. Bloom, H. J.; Bessell, E. M. Medulloblastoma in adults: A review of 47 patients treated between 1952 and 1981. Int. J. Radiat. Oncol. Biol. Phys. 18:763-772; 1990.
6. Bloom, H. J. G.; Wallace, E. N. K.; Henk, J. M. The treatment and prognosis of medulloblastoma in children. AJR 105:43-62, 1969.
7. Chang, C. H.; Housepian, E. M.; Herbert, J. An operative staging system and a megavoltage radiotherapeutic technique for cerebellar medulloblastomas. Radiology 93:1351-1359; 1969.
8. Cushing, H. Experiences with the cerebellar medulloblastomas: A critical review. Acta Pathol. Microbiol. Scand. 1:1-86; 1930.
9. Deutsch, M.; Thomas, P. R. M.; Krischer, J.; Boyett, J. M.; Albright, L.; Aronin, P.; Langston, J.; Allen, J. C.; Packer, R. P.; Linggood, R.; Mulhern, R.; Stanley, P.; Stehbens, J. A.; Duffner, P.; Kun, L.; Rorke, L.; Cherlow, J.; Friedman, H.; Finlay, J. L.; Vietti, T. Results of a prospective randomized trial comparing standard dose neuraxis irradiation (36.00 Gy/20) with reduced neuraxis irradiation (23.40 Gy/ 13) in patients with low stage medulloblastoma. A combined Children's Cancer Group - Pediatric Oncology Group study. Pediatr. Neurosurg. 24:167-177; 1996.
10. Duffner, P. K.; Horowitz, M. E.; Krischer, J. P.; Friedman, H. S.; Burger, P. C.; Cohen, M. E.; Sanford, R. A.; Mulhern, R. K.; James, H. E.; Freeman, C. R.; Seidel F. G.; Kun, L. E. Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N. Engl. J. Med. 328:1725-1731; 1993.
11. Dupuis-Girod, S.; Hartmann, O.; Benhamou, E.; Doz, F.; Mechinaud, F.; Bouffet, E.; Coze, C.; Kalifa, C. Will high dose chemotherapy followed by autologous bone marrow transplantation supplant cranio-spinal irradiation in young children treated for medulloblastoma? J. Neurooncol. 27:87-98; 1996.
12. Evans, A. E.; Jenkin, R. D. T.; Sposto, R.; Ortega, J. A.; Wilson, C. B.; Wara, W.; Ertel, I. J.; Kramer, S.; Chang, C. H.; Leikin, S. L.; Hammond, G. D. The treatment of medulloblastoma: Results of a prospective randomized trial of radiation therapy with and without CCNU, vincristine and prednisone. J. Neurosurg. 72:572-582; 1990.
13. Gajjar, A.; Mulhern, R. K.; Heideman, R. L.; Sanford, R. A.; Douglas, E. C.; Kovnar, E. H.; Langston, J. A.; Jenkins, J. J.; Kun, L. E. Medulloblastoma in very young children: Outcome of definitive craniospinal irradiation following incomplete response to chemotherapy. J. Clin. Oncol. 12:1212-1216; 1994.
14. Gentet, J. C.; Bouffet, E.; Doz, F.; Tron, P.; Roche, H.; Thyss, A.; Plantaz, D.; Stephan, J. L.; Mottolese, C.; Ponvert, D.; Carrie, C.; Raybaud, C.; Brunat-Mentigny, M.; Choux, M.; Philip, T.; Zucker, J. M.; Bernard, J. L. Preirradiation chemotherapy including ' 'eight drugs in 1 day regimen and high-dose methotrexate in childhood medulloblastoma: Results of the M7 French Cooperative Study. J. Neurosurg. 82:608-614; 1995.
15. Geyer, R. J.; Zeltzer, P. M.; Boyett, J. M.; Rorke, L. B.; Stanley, P.; Albright, A. L.; Wisoff, J. H.; Milstein, J. M.; Allen, J. C.; Finlay, J. L.; Ayers, G. D.; Shurin, S. B.; Stevens, K. R.; Bleyer, A. W. Survival of infants with primitive neuroectodermal tumors or malignant ependymomas of the CNS treated with eight drugs in 1 day: A report from the Childrens Cancer Group. J. Clin. Oncol. 12:1607-1615; 1994.
16. Heideman, R. L.; Kovnar, E. H.; Kellie, S. J.; Douglass, E. C.; Gajjar, A. J.; Walter, A. W.; Langston, J. A.; Jenkins, J. J.; Li, Y.; Greenwald, C.; Sanford, R. A.; Kun, L. E. Preirradiation chemotherapy with carboplatin and VP-16 in newly diagnosed embryonal pediatric central nervous system tumors. J. Clin. Oncol. 13:2247-2254, 1995..
17. Horowitz, M. E.; Kun, L. E.; Mulhern, R. K.; et al. Feasibility and efficacy of preirradiation chemotherapy for pediatric brain tumors. Neurosurgery 22:687-690; 1988.
18. Horowitz, M. E.; Mulhern, R. K.; Kun, L. E.; et al. Brain tumors in the very young child: Postoperative chemotherapy in combined modality treatment. Cancer 61:428-434; 1988.
19. Hughes, E. N.; Shilito, J.; Sallan, S. E.; et al. Medulloblastoma at the Joint Center for Radiation Therapy between 1968 and 1984: The influence of radiation dose on the patterns of failure and survival. Cancer 61:1992-1998, 1988.
20. Jenkin, D.; Goddard, K.; Armstrong, D.; Becker, L.; Berry, M.; Chan, H.; Doherty, M.; Greenberg, M.; Hendrick, B.; Hoffman, H.; Humphreys, R.; Sonley, M.; Weitzman, S.; Zipursky, A. Posterior fossa medulloblastoma in childhood: Treatment results and a proposal for a new staging system. Int. J. Radiat. Oncol. Biol. Phys. 19:265-274; 1990.
21. Kalbfleisch, J. D.; Prentice, R. L. The statistical analysis of failure time data. New York: John Wiley and Sons; 1980:169.
22. Kaplan, E. L.; Meier, P. Nonparametric estimates from incomplete observations. J. Am. Stat. Assoc. 53:457-448; 1957.
23. Kovnar, E. H.; Kellie, S. J.; Horowitz, M. E.; Sanford, R. A.; Langston, J. W.; Mulhern, R. K.; Jenkins, J. J.; Douglass, E. C.; Etcubanas, E. E.; Fairclough, D. L.; Kun, L. E. Preirradiation cisplatin and etoposide in the treatment of high-risk medulloblastoma and other malignant embryonal tumors of the central nervous system: A phase II study. J. Clin. Oncol. 8:330-336; 1990.
24. Landberg, T. G.; Lindgren, M. L.; Cavallin-Stahl, E. K.; Svahn-Tapper, G. O.; Sundbarg, G.; Garwicz, S.; Lagergren, J. A.; Gunnesson, V. L.; Brun, A. E.; Cronqvist, S. E. Improvements in the radiotherapy of medulloblastoma, 1946-1975. Cancer 45:670-678; 1980.
25. Loeffler, J. S.; Kretschmar, C. S.; Sallan, S. E.; LaVally, B. L.; Winston, K. R.; Fischer, E. G.; Tarbell, N. J. Preradiation chemotherapy for infants and poor prognosis children with medulloblastoma. Int. J. Radiat. Oncol. Biol. Phys. 15:177-181; 1988.
26. Mosijczuk, A. D.; Nigro, M. A.; Thomas, P. R.; Burger, P. C.; Krischer, J. P.; Morantz, R. A.; Kurdunowicz, B.; Mulne, A. F.; Towbin, R. B.; Freeman, A. I.; Nigro, E. D.; Friedman, H. S.; Kun, L. E. Preradiation chemotherapy in advanced medulloblastoma: A Pediatric Oncology Group pilot study. Cancer 72:2755-2762; 1993.
27. Nicholson, H. S.; Zeltzer, P. M.; Li, H.; Boyett, J. M.; Finlay, J.; Albright, L.; Wisoff, J.; Geyer, R.; McGuire-Cullen, P.; Rorke, L.; Stevens, K.; Shurin, S.; Milstein, J.; Packer, R. J. Patterns of failure in high-risk posterior fossa PNET/medulloblastoma (MB) patients treated with radiotherapy (XRT) and chemotherapy (CT). Med. Pediatr. Oncol. 25:238; 1995.
28. Packer, R. J.; Sutton, L. N.; Elterman, R.; Lange, B.; Goldwein, J.; Nicholson, H. S.; Mulne, L.; Boyett, J.; D'Angio, G.; Wechsler-Jentzsch, K.; Reaman, G.; Cohen, B. H.; Bruce, D. A.; Rorke, L. B.; Molloy, P.; Ryan, J.; LaFond, D.; Evans, A. E.; Schut, L. Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU and vincristine chemotherapy. J. Neurosurg. 81:690-698; 1994.
29. Patterson, E.; Farr, R. F. Cerebellar medulloblastoma: Treatment by irradiation of the whole central nervous system. Acta Radiol. 39:323-336; 1953.
30. Peto, R.; Pike, M. C.; Armitage, P.; et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II: Analysis and examples. Br. J. Cancer 35:1-39; 1977.
31. Radcliffe, J.; Bunin, G. R.; Sutton, L. N.; Goldwein, J. W.; Phillips, P. C. Cognitive deficits in long-term survivors of childhood medulloblastoma and other noncortical tumors: Age-dependent effects of whole brain irradiation. Int. J. Dev. Neurosci. 12:327-334; 1994.
32. Tait, D. M.; Thornton-Jones, H.; Bloom, H. J. G.; Lemerle, J.; Morris-Jones, P. Adjuvant chemotherapy for medulloblastoma: The first multi-centre control trial of the International Society of Pediatric Oncology (SIOP I). Eur. J. Cancer 26:464-469; 1990.
33. Tornesello, A.; Mastrangelo, S.; Piciacchia D.; Lasorella, A.; Riccardi, R.; Mastrangelo, R. Disease progression during preirradiation chemotherapy in children with medulloblastoma/PNET. Med. Pediatr. Oncol. 25:238; 1995.
34. Zeltzer, P. M.; Boyett, J.; Finlay, J.; Albright, L.; Wisoff, J.; Geyer, R.; McGuire, P.; Stanley, P.; Stehbens, J.; Stevens, K.; Shurin, S.; Rorke, L.; Milstein, J.; Allen, J.; Packer, R.; Bleyer, A. Tumor staging at diagnosis and therapy type for primitive neuroectodermal tumors (PNET) determine survival: Report from Childrens Cancer Study CCG-921. Med. Pediatr. Oncol. 25:238; 1995.