Obesity: Mediators and treatment approaches

Diabetes Care

Volumn 32, Issue 5, 2009, Pages

  Bloomgarden, Zachary T ^a,b  

^a Mount Sinai School of Medicine ^*

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; ANTIOBESITY AGENT; CATECHOLAMINE; CORTICOSTERONE; G PROTEIN COUPLED RECEPTOR; GASTROINTESTINAL HORMONE; GHRELIN; GLUCOCORTICOID; INSULIN; INSULIN GLARGINE; LEPTIN; METFORMIN; METRELEPTINE; NEUROPEPTIDE Y; NORADRENALIN; OXYNTOMODULIN; PEPTIDE YY; PEPTIDE YY [3-36]; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; PHENTERMINE; PLACEBO; PRAMLINTIDE; RIMONABANT; SIBUTRAMINE; SULFONYLUREA; TOPIRAMATE; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ADIPOGENESIS; ANXIETY; AUTONOMIC NERVOUS SYSTEM; BARIATRIC SURGERY; COMBINATION CHEMOTHERAPY; CONFERENCE PAPER; CONTINUOUS INFUSION; DEPRESSION; DIABETES MELLITUS; DIET THERAPY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG MECHANISM; ENERGY EXPENDITURE; FOOD INTAKE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HYPERTRIGLYCERIDEMIA; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; LIPID METABOLISM; LIPOLYSIS; METABOLIC SYNDROME X; MONOTHERAPY; NAUSEA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; RISK ASSESSMENT; ROUX Y ANASTOMOSIS; SIDE EFFECT; STOMACH BYPASS;

AMYLOID; ANTI-OBESITY AGENTS; APPETITE; BARIATRIC SURGERY; DIABETES COMPLICATIONS; DIABETES MELLITUS; DIET, CARBOHYDRATE-RESTRICTED; FATTY LIVER; FEMALE; GASTRIC EMPTYING; HUMANS; INSULIN; LIPOLYSIS; MALE; NEUROPEPTIDE Y; OBESITY;

EID: 65949110150     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc09-zb05     Document Type: Conference Paper

References (18)

1. Eva C, Serra M, Mele P, Panzica G, Oberto A: Physiology and gene regulation of the brain NPY Y1 receptor. Front Neuroendocrinol 2006;27:308-339 (Pubitemid 44548041)
2. Abe K, Tilan JU, Zukowska Z: NPY and NPY receptors in vascular remodeling. Curr Top Med Chem 2007;7:1704-1709 (Pubitemid 350131007)
3. Kuo LE, Kitlinska JB, Tilan JU, Li L, Baker SB, Johnson MD, Lee EW, Burnett MS, Fricke ST, Kvetnansky R, Herzog H, Zukowska Z: Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat Med 2007;13:803-811 (Pubitemid 47038195)
4. Large V, Hellström L, Reynisdottir S, Lönnqvist F, Eriksson P, Lannfelt L, Arner P: Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function. J Clin Invest 1997;100:3005-3013 (Pubitemid 28022837)
5. Dahlman I, Arner P: Obesity and polymorphisms in genes regulating human adipose tissue. Int J Obes (Lond) 2007;31:1629-1641 (Pubitemid 350023156)
6. Dahlman I, Dicker A, Jiao H, Kere J, Blomqvist L, van Harmelen V, Hoffstedt J, Borch-Johnsen K, Jorgensen T, Hansen T, Pedersen O, Laakso M, Arner P: A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis. Am J Hum Genet 2007;80:1115-1124 (Pubitemid 47579347)
7. Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, Bergmann O, Blomqvist L, Hoffstedt J, Näslund E, Britton T, Concha H, Hassan M, Rydén M, Frisén J, Arner P: Dynamics of fat cell turnover in humans. Nature 2008;453:783-787
8. Sjöström L, Narbro K, Sjöström CD, Karason K, Larsson B, Wedel H, Lystig T, Sullivan M, Bouchard C, Carlsson B, Bengtsson C, Dahlgren S, Gummesson A, Jacobson P, Karlsson J, Lindroos AK, Lönroth H, Näslund I, Olbers T, Stenlöf K, Torgerson J, Agren G, Carlsson LM: Swedish Obese Subjects Study. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007 Aug 23;357:741-752
9. Adams TD, Gress RE, Smith SC, Halverson RC, Simper SC, Rosamond WD, Lamonte MJ, Stroup AM, Hunt SC: Long-term mortality after gastric bypass surgery. N Engl J Med 2007;357:753-761 (Pubitemid 47295642)
10. Tatemoto K: Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc Natl Acad Sci U S A 1982;79:2514-2518 (Pubitemid 12068399)
11. Adrian TE, Ferri GL, Bacarese-Hamilton AJ, Fuessl HS, Polak JM, Bloom SR: Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 1985;89:1070-1077 (Pubitemid 16231572)
12. Adrian TE, Savage AP, Fuessl HS, Wolfe K, Besterman HS, Bloom SR: Release of peptide YY (PYY) after resection of small bowel, colon, or pancreas in man. Surgery 1987;101:715-719 (Pubitemid 17103572)
13. Vella A, Bock G, Giesler PD, Burton DB, Serra DB, Saylan ML, Deacon CF, Foley JE, Rizza RA, Camilleri M: The effect of dipeptidyl peptidase-4 inhibition on gastric volume, satiation and enteroendocrine secretion in type 2 diabetes: a double-blind, placebo-controlled cross-over study. Clin Endocrinol (Oxf) 2008;69:737-744
14. Barrot M, Abrous DN, Marinelli M, Rougé-Pont F, Le Moal M, Piazza PV: Influence of glucocorticoids on dopaminergic transmission in the rat dorsolateral striatum. Eur J Neurosci 2001;13:812-818 (Pubitemid 32174806)
15. Warne JP, Foster MT, Horneman HF, Pecoraro NC, Ginsberg AB, Akana SF, Dallman MF: Hepatic branch vagotomy, like insulin replacement, promotes voluntary lard intake in streptozotocin-diabetic rats. Endocrinology 2007;148:3288-3298 (Pubitemid 46996976)
16. Warne JP, Horneman HF, Ginsberg AB, Pecoraro NC, Foster MT, Akana SF, Dallman MF: Mapping brain c-Fos immunoreactivity after insulin-induced voluntary lard intake: insulin- and lard-associated patterns. J Neuroendocrinol 2007;19:794-808 (Pubitemid 47386881)
17. Dallman MF, Warne JP, Foster MT, Pecoraro NC: Glucocorticoids and insulin both modulate caloric intake through actions on the brain. J Physiol 2007;583:431-436 (Pubitemid 47343481)
18. Roth JD, Roland BL, Cole RL, Trevaskis JL, Weyer C, Koda JE, Anderson CM, Parkes DG, Baron AD: Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies. Proc Natl Acad Sci U S A 2008;105:7257-7262