Prevalence of antiphospholipid and antinuclear antibodies in children with epilepsy

Medical Science Monitor

Volumn 15, Issue 4, 2009, Pages

  Constantin, Tamás ^a,c   Kálovics, Tamás ^a   Ponyi, Andrea ^a   Nagy, Eszter ^a   Sallai, Krisztina ^a   Szabó, Léna ^a   Garami, Miklós ^a   Müller, Judit ^a   Gergely, Péter ^a   Dankó, Katalin ^b   Fekete, György ^a   Kálmánchey, Rozália ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Antiphospholipid antibodies; Epilepsy; Lupus anticoagulant

Indexed keywords

ANTINUCLEAR ANTIBODY; BETA2 GLYCOPROTEIN 1; CARDIOLIPIN ANTIBODY; PHOSPHOLIPID ANTIBODY;

ADOLESCENT; ARTICLE; AUTOIMMUNE DISEASE; CHILD; CONTROLLED STUDY; EPILEPSY; FEMALE; HUMAN; IMMUNOMODULATION; INFANT; LANDAU KLEFFNER SYNDROME; LUPUS VULGARIS; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRESCHOOL CHILD;

ADOLESCENT; ADULT; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, ANTIPHOSPHOLIPID; CHILD; CHILD, PRESCHOOL; EPILEPSY; FEMALE; HUMANS; INFANT; MALE;

EID: 65949098381     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Cervera R, Piette JC, Font J et al: Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum, 2002; 46(4): 1019-1027
2. Lee T, von Scheven E, Sandborg C: Systemic lupus erythematosus and antiphospholipid syndrome in children and adolescents. Curr Opin Rheumatol, 2001; 13(5): 415-421
3. Asherson RA, Lanham JG, Hull RG et al: Renal vein thrombosis in systemic lupus erythematosus: association with the "lupus anticoagulant". Clin Exp Rheumatol, 1984; 2(1): 75-79
4. Boey ML, Colaco CB, Gharavi AE et al: Thrombosis in systemic lupus erythematosus: striking association with the presence of circulating lupus anticoagulant. Br Med J (Clin Res Ed), 1983; 287(6398): 1021-1023
5. Harris EN, Gharavi AE, Boey ML et al: Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet, 1983; 2(8361): 1211-1214
6. Harris EN, Gharavi AE, Asherson RA, Hughes GR: Antiphospholipid antibodies: a review. Eur J Rheumatol Inflamm, 1984; 7(1): 5-8
7. Lockshin MD, Sammaritano LR, Schwartzman S: Validation of the Sapporo criteria for antiphospholipid syndrome. Arthritis Rheum, 2000; 43(2): 440-443
8. Wilson WA, Gharavi AE, Koike T et al: International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum, 1999; 42(7): 1309-1311
9. Wilson WA: Classification criteria for antiphospholipid syndrome. Rheum Dis Clin North Am, 2001; 27(3): 499-505
10. Wilson WA, Gharavi AE, Piette JC: International classification criteria for antiphospholipid syndrome: synopsis of a post-conference workshop held at the Ninth International (Tours) aPL Symposium. Lupus, 2001; 10(7): 457-460
11. Brey RL, Chapman J, Levine SR et al: Stroke and the antiphospholipid syndrome: consensus meeting Taormina 2002. Lupus, 2003; 12(7): 508-513
12. Antunes MC, D'Cruz D, Hughes GR: Neurological manifestations of anti-phospholipid (Hughes) syndrome. Clin Exp Rheumatol, 2004; 22(6): 771-775
13. Lampropoulos CE, Hughes GR: The antiphospholipid (Hughes') syndrome: changing the face of neurology. Eur J Intern Med, 2004; 15(3): 147-150
14. Verrot D, San-Marco M, Dravet C et al: Prevalence and signification of antinuclear and anticardiolipin antibodies in patients with epilepsy. Am J Med, 1997; 103(1): 33-37
15. Peltola JT, Haapala A, Isojarvi JI et al: Antiphospholipid and antinuclear antibodies in patients with epilepsy or new-onset seizure disorders. Am J Med, 2000; 109(9): 712-717
16. Cimaz R, Meroni PL, Shoenfeld Y: Epilepsy as part of systemic lupus erythematosus and systemic antiphospholipid syndrome (Hughes syndrome). Lupus, 2006; 15(4): 191-197
17. Yoshimura K, Konishi T, Kotani H et al: Prevalence of positive anticardiolipin antibody in benign infantile convulsion. Brain Dev, 2001; 23(5): 317-320
18. Angelini L, Granata T, Zibordi F et al: Partial seizures associated with antiphospholipid antibodies in childhood. Neuropediatrics, 1998; 29(5): 249-253
19. Spreafico R, Binelli S, Bruzzone MG et al: Primary antiphospholipid syndrome (PAPS) and isolated partial seizures in adolescence. A case report. Ital J Neurol Sci, 1994; 15(6): 297-301
20. Eriksson K, Peltola J, Keranen T et al: High prevalence of antiphospholipid antibodies in children with epilepsy: a controlled study of 50 cases. Epilepsy Res, 2001; 46(2): 129-137
21. Liou HH, Wang CR, Chou HC et al: Anticardiolipin antisera from lupus patients with seizures reduce a GABA receptor-mediated chloride current in snail neurons. Life Sci, 1994; 54(15): 1119-1125
22. Meroni PL, Raschi E, Camera M et al: Endothelial activation by aPL: a potential pathogenetic mechanism for the clinical manifestations of the syndrome. J Autoimmun, 2000; 15(2): 237-240
23. Caronti B, Calderaro C, Alessandri C et al: Serum anti-beta2-glycoprotein I antibodies from patients with antiphospholipid antibody syndrome bind central nervous system cells. J Autoimmun, 1998; 11(5): 425-429
24. Katzav A, Chapman J, Shoenfeld Y: CNS dysfunction in the antiphospholipid syndrome. Lupus, 2003; 12(12): 903-907
25. Katzav A, Litvinjuk Y, Pick CG et al: Genetic and immunological factors interact in a mouse model of CNS antiphospholipid syndrome. Behav Brain Res, 2006; 169(2): 289-293
26. Chapman J, Rand JH, Brey RL et al: Non-stroke neurological syndromes associated with antiphospholipid antibodies: evaluation of clinical and experimental studies. Lupus, 2003; 12(7): 514-517
27. Chapman J, Shoenfeld Y: Neurological and neuroendocrine-cytokine inter-relationship in the antiphospholipid syndrome. Ann NY Acad Sci, 2002; 966: 415-424
28. Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia, 1989; 30(4): 389-399
29. Wolf P: Basic principles of the ILAE syndrome classification. Epilepsy Res, 2006; 70(Suppl.1): S20-26
30. Landau WM, Kleffner FR: Syndrome of acquired aphasia with convulsive disorder in children. Neurology, 1957; 7(8): 523-530
31. Landau WM: Landau-Kleffner syndrome. An eponymic badge of ignorance. Arch Neurol, 1992; 49(4): 353
32. Dzienis W, Tarasow E, Kochanowicz J et al: Utility of computed tomography and selected MR sequences in the diagnostics of patients with partial epileptic attacks. Med Sci Monit, 2007; 13(Suppl.1): 49-54
33. Caksen H, Oner AF, Arslan S et al: Immunoglobulin subgroups in children with febrile seizures. Pediatr Int, 2001; 43(1): 58-60
34. Braconier JH: Reversible total IgA deficiency associated with phenytoin treatment. Scand J Infect Dis, 1999; 31(5): 515-516
35. Gilhus NE, Hammarstrom L: Anti-IgA antibodies in epileptic patients with a low serum IgA concentration. Int J Immunopharmacol, 1991; 13(2-3): 185-188
36. Cimaz R, Romeo A, Scarano A et al: Prevalence of anti-cardiolipin, anti-beta2 glycoprotein I, and anti-prothrombin antibodies in young patients with epilepsy. Epilepsia, 2002; 43(1): 52-59 (Pubitemid 34215453)
37. Yadin O, Sarov B, Naggan L et al: Natural autoantibodies in the serum of healthy women - a five-year follow-up. Clin Exp Immunol 1989;75(3): 402-406 (Pubitemid 19109988)
38. Goel KM, Shanks RA, Whaley K, Mason M, MacSween RN: Autoantibodies in childhood connective tissue diseases and in normal children. Arch Dis Child, 1975; 50(6): 419-423
39. Fernandez SA, Lobo AZ, Oliveira ZN et al: Prevalence of antinuclear autoantibodies in the serum of normal blood dornors. Rev Hosp Clin Fac Med Sao Paulo, 2003; 58(6): 315-319
40. Al Jabri AA, Al Buloshi MS: Anticardiolipin and antinuclear antibodies in the adult healthy Omani individuals. Saudi Med J, 2004; 25(3): 313-317
41. Reyes H, Dearing L, Shoenfeld Y, Peter JB: Antiphospholipid antibodies: a critique of their heterogeneity and hegemony. Semin Thromb Hemost, 1994; 20(1): 89-100
42. Shi W, Krilis SA, Chong BH et al: Prevalence of lupus anticoagulant and anticardiolipin antibodies in a healthy population. Aust N Z J Med, 1990; 20(3): 231-236
43. Vila P, Hernandez MC, Lopez-Fernandez MF, Batlle J: Prevalence, follow-up and clinical significance of the anticardiolipin antibodies in normal subjects. Thromb Haemost, 1994; 72(2): 209-213 (Pubitemid 24251281)
44. Trouw LA, Daha MR: Role of anti-C1q autoantibodies in the pathogenesis of lupus nephritis. Expert Opin Biol Ther, 2005; 5(2): 243-251
45. Reveille JD: Predictive value of autoantibodies for activity of systemic lupus erythematosus. Lupus, 2004; 13(5): 290-297
46. Seelen MA, Trouw LA, Daha MR: Diagnostic and prognostic significance of anti-C1q antibodies in systemic lupus erythematosus. Curr Opin Nephrol Hypertens, 2003; 12(6): 619-624
47. Tuzun E, Saini SS, Ghosh S et al: Predictive value of serum anti-C1q antibody levels in experimental autoimmune myasthenia gravis. Neuromuscul Disord, 2006; 16(2): 137-143
48. Sanna G, Bertolaccini ML, Hughes GR: Hughes syndrome, the antiphospholipid syndrome: a new chapter in neurology. Ann NY Acad Sci, 2005; 1051: 465-486 (Pubitemid 41362776)
49. Ranua J, Luoma K, Peltola J et al: Anticardiolipin and antinuclear antibodies in epilepsy - a population-based cross-sectional study. Epilepsy Res, 2004; 58(1): 13-18
50. Peltola J, Eriksson K, Keranen T: Cytokines and seizures. Arch Neurol, 2001; 58(7): 1168-1169
51. Peltola J, Palmio J, Korhonen L et al: Interleukin-6 and interleukin-1 receptor antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures. Epilepsy Res, 2000; 41(3): 205-211
52. Vezzani A, Moneta D, Richichi C et al: Functional role of proinflammatory and anti-inflammatory cytokines in seizures. Adv Exp Med Biol, 2004; 548: 123-133
53. Aarli JA: Role of cytokines in neurological disorders. Curr Med Chem, 2003; 10(19): 1931-1933