Elevated serum levels of caspase-cleaved cytokeratin 18 (CK18-Asp396) in patients with nonalcoholic steatohepatitis and chronic hepatitis C

Medical Science Monitor

Volumn 15, Issue 4, 2009, Pages

  Yilmaz, Yusuf ^a   Dolar, Enver ^a   Ulukaya, Engin ^a   Akgoz, Semra ^a   Keskin, Murat ^a   Kiyici, Murat ^a   Yerci, Omer ^a   Oral, Arzu Yilmaztepe ^a   Gul, Cuma Bulent ^a   Gurel, Selim ^a   Nak, Selim Giray ^a   Gulten, Macit ^a  

^a ULUDAG UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Biomarker; Chronic hepatitis C; Histopathology; Nonalcoholic steatohepatitis

Indexed keywords

CASPASE; CYTOKERATIN 18;

ADULT; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ANALYSIS; FEMALE; HEPATITIS C; HUMAN; KRUSKAL WALLIS TEST; MALE; NONALCOHOLIC FATTY LIVER;

ADOLESCENT; ADULT; AGED; CASPASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FATTY LIVER; FEMALE; HEPATITIS C, CHRONIC; HUMANS; HYDROLYSIS; KERATIN-18; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 65949083563     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Ramesh S, Sanyal AJ: Hepatitis C and nonalcoholic fatty liver disease. Semin Liver Dis, 2004; 24: 399-413
2. Wieckowska A, Zein NN, Yerian LM et al: In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology, 2006; 44: 27-33
3. Ramalho RM, Cortez-Pinto H, Castro RE et al: Apoptosis and Bcl-2 expression in the livers of patients with steatohepatitis. Eur J Gastroenterol Hepatol, 2006; 18: 21-29
4. Kronenberger B, Ruster B, Lee JH et al: Hepatocellular proliferation in patients with chronic hepatitis C and persistently normal or abnormal aminotransferase levels. J Hepatol, 2000; 33: 640-647
5. Yagmur E, Trautwein C, Leers MP et al: Elevated apoptosis-associated cytokeratin 18 fragments (CK18Asp386) in serum of patients with chronic liver diseases indicate hepatic and biliary inflammation. Clin Biochem, 2007; 40: 651-655
6. Ueno T, Toi M, Bivén K et al: Measurement of an apoptotic product in the sera of breast cancer patients. Eur J Cancer, 2003; 39: 769-774
7. Roth GA, Krenn C, Brunner M et al: Elevated serum levels of epithelial cell apoptosis-specific cytokeratin 18 neoepitope m30 in critically ill patients. Shock, 2004; 22: 218-220
8. Linder S, Havelka AM, Ueno T, Shoshan MC: Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker. Cancer Lett, 2004; 214: 1-9
9. Kramer G, Erdal H, Mertens HJ et al: Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18. Cancer Res, 2004; 64: 1751-1756
10. Yilmaz Y, Dolar E, Ulukaya E et al: Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis. World J Gastroenterol, 2007; 13: 837-844
11. Kronenberger B, Wagner M, Herrmann E et al: Apoptotic cytokeratin 18 neoepitopes in serum of patients with chronic hepatitis C. J Viral Hepat, 2005; 12: 307-314
12. Kleiner DE, Brunt EM, Van Natta M et al: Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology, 2005; 41: 1313-1321
13. Knodell RG, Ishak KG, Black WC et al: Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology, 1981; 14: 431-435
14. Ribeiro PS, Cortez-Pinto H, Solá S et al: Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. Am J Gastroenterol, 2004; 99: 1708-1717 (Pubitemid 39237497)
15. Caulin C, Salvesen GS, Oshima RG: Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J Cell Biol,1997; 138: 1379-1394 (Pubitemid 27415063)
16. Duan WR, Garner DS, Williams SD et al: Comparison of immunohistochemistry for activated caspase-3 and cleaved cytokeratin 18 with the TUNEL method for quantification of apoptosis in histological sections of PC-3 subcutaneous xenografts. J Pathol, 2003; 199: 221-228
17. Seidel N, Volkmann X, Länger F et al: The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum. Hepatology, 2005; 42: 113-120