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Volumn 4, Issue 5, 2009, Pages

Dominant negative mutants of Bacillus thuringiensis Cry1Ab toxin function as anti-toxins: Demonstration of the role of oligomerization in toxicity

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CRY1AB TOXIN; DOMINANT NEGATIVE INHIBITOR; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; ENDOTOXIN; HEMOLYSIN; INSECTICIDAL CRYSTAL PROTEIN, BACILLUS THURINGIENSIS; INSECTICIDE;

EID: 65849141019     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005545     Document Type: Article
Times cited : (48)

References (36)
  • 4
    • 30544442384 scopus 로고    scopus 로고
    • Transgenic crops expressing Bacillus thuringiensis toxins and biological control
    • Romeis J, Meissle M, Bigler F (2006) Transgenic crops expressing Bacillus thuringiensis toxins and biological control. Nature Biotechnol 24: 63-71.
    • (2006) Nature Biotechnol , vol.24 , pp. 63-71
    • Romeis, J.1    Meissle, M.2    Bigler, F.3
  • 6
    • 33846574821 scopus 로고    scopus 로고
    • Increase response to cadmium and Bacillus thuringiensis maize toxicity in the snail Helix aspersa infected by the nematode Phamarhabditis hermaphodita
    • Kramarz PE, de Vaufleury A, Zygmunt PM, Verdun C (2007) Increase response to cadmium and Bacillus thuringiensis maize toxicity in the snail Helix aspersa infected by the nematode Phamarhabditis hermaphodita. Environ Toxicol Chem 26: 73-79.
    • (2007) Environ Toxicol Chem , vol.26 , pp. 73-79
    • Kramarz, P.E.1    de Vaufleury, A.2    Zygmunt, P.M.3    Verdun, C.4
  • 7
    • 0038477096 scopus 로고    scopus 로고
    • Effects of transgenic Bt corn litter on the earthworm Lumbricus terrestres
    • Zwahlen C, Hilbeck A, Howald R, Nentwig W (2003) Effects of transgenic Bt corn litter on the earthworm Lumbricus terrestres. Mol Ecol 12: 1077-1086.
    • (2003) Mol Ecol , vol.12 , pp. 1077-1086
    • Zwahlen, C.1    Hilbeck, A.2    Howald, R.3    Nentwig, W.4
  • 9
    • 54049138395 scopus 로고    scopus 로고
    • Occurrence of the transgenic corn cry1Ab gene in freshwater mussels (Elliptio complanata) near corn fields: Evidence of exposure by bacterial ingestion
    • Douville M, Gagné F, André C, Blaise C (2009) Occurrence of the transgenic corn cry1Ab gene in freshwater mussels (Elliptio complanata) near corn fields: Evidence of exposure by bacterial ingestion. Ecotoxicol Environ Saf 72: 17-23.
    • (2009) Ecotoxicol Environ Saf , vol.72 , pp. 17-23
    • Douville, M.1    Gagné, F.2    André, C.3    Blaise, C.4
  • 10
    • 9244241054 scopus 로고    scopus 로고
    • Pore forming protein toxins: From structure to function
    • Parker MW, Feil SC (2005) Pore forming protein toxins: from structure to function. Progress Biophys Mol Biol 88: 91-124.
    • (2005) Progress Biophys Mol Biol , vol.88 , pp. 91-124
    • Parker, M.W.1    Feil, S.C.2
  • 11
    • 4444317796 scopus 로고    scopus 로고
    • Antitoxins: Novel strategies to target agents of bioterrorism
    • Rainey GJ, Young JA (2004) Antitoxins: novel strategies to target agents of bioterrorism. Nature Rev Microbiol 2: 721-726.
    • (2004) Nature Rev Microbiol , vol.2 , pp. 721-726
    • Rainey, G.J.1    Young, J.A.2
  • 12
    • 0035984720 scopus 로고    scopus 로고
    • Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity
    • Maynard JA, Maassen CB, Lappla SH, Brasky K, Patterson JL, et al. (2002) Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity. Nature Biotechnol 20: 597-601.
    • (2002) Nature Biotechnol , vol.20 , pp. 597-601
    • Maynard, J.A.1    Maassen, C.B.2    Lappla, S.H.3    Brasky, K.4    Patterson, J.L.5
  • 13
    • 0038303163 scopus 로고    scopus 로고
    • Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor
    • Scobie HM, Rainey GJ, Bradley KA, Young JA (2003) Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc Natl Acad Sci USA 100: 5170-5174.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5170-5174
    • Scobie, H.M.1    Rainey, G.J.2    Bradley, K.A.3    Young, J.A.4
  • 14
    • 0042838115 scopus 로고    scopus 로고
    • Characterization of dominantly negative mutant ClyA Cytotoxin proteins in Escherichia coli
    • Wai SN, Westermark M, Oscarsson J, Jass J, Maier E, et al. (2003) Characterization of dominantly negative mutant ClyA Cytotoxin proteins in Escherichia coli. J Bacteriol 185: 5491-5499.
    • (2003) J Bacteriol , vol.185 , pp. 5491-5499
    • Wai, S.N.1    Westermark, M.2    Oscarsson, J.3    Jass, J.4    Maier, E.5
  • 15
    • 0033621333 scopus 로고    scopus 로고
    • A dominant negative mutant of Helicobacter pylori vacuolating toxin Vac A inhibits VacA-induced cell vacuolation
    • Vinion-Dubiel A, McClain MS, Czajkowsky DM, Iwamoto H, Ye D, et al. (1999) A dominant negative mutant of Helicobacter pylori vacuolating toxin Vac A inhibits VacA-induced cell vacuolation. J Biol Chem 274: 37736-37742.
    • (1999) J Biol Chem , vol.274 , pp. 37736-37742
    • Vinion-Dubiel, A.1    McClain, M.S.2    Czajkowsky, D.M.3    Iwamoto, H.4    Ye, D.5
  • 16
    • 0035957753 scopus 로고    scopus 로고
    • Dominant-negative mutants of a toxin subunit: An approach to therapy of anthrax
    • Sellman BR, Mourez M, Collier RJ (2001) Dominant-negative mutants of a toxin subunit: an approach to therapy of anthrax. Science 292: 695-697.
    • (2001) Science , vol.292 , pp. 695-697
    • Sellman, B.R.1    Mourez, M.2    Collier, R.J.3
  • 17
    • 0037181168 scopus 로고    scopus 로고
    • Cadherin-like receptor binding facilitates proteolytic cleavage of helix α-1 in domain I and oligomer pre-pore formation of Bacillus thuringiensis Cry1Ab toxin
    • Gómez I, Sánchez J, Miranda R, Bravo A, Soberón M (2002) Cadherin-like receptor binding facilitates proteolytic cleavage of helix α-1 in domain I and oligomer pre-pore formation of Bacillus thuringiensis Cry1Ab toxin. FEBS Lett 513: 242-246.
    • (2002) FEBS Lett , vol.513 , pp. 242-246
    • Gómez, I.1    Sánchez, J.2    Miranda, R.3    Bravo, A.4    Soberón, M.5
  • 18
    • 7744222624 scopus 로고    scopus 로고
    • Oligomerization triggers binding of a Bacillus thuringiensis Cry1Ab pore-forming toxin to aminopeptidase N receptor leading to insertion into membrane microdomains
    • Bravo A, Gómez I, Conde J, Muñoz-Garay C, Sánchez, et al. (2004) Oligomerization triggers binding of a Bacillus thuringiensis Cry1Ab pore-forming toxin to aminopeptidase N receptor leading to insertion into membrane microdomains. Biochim Biophys Acta 1667: 38-46.
    • (2004) Biochim Biophys Acta , vol.1667 , pp. 38-46
    • Bravo, A.1    Gómez, I.2    Conde, J.3    Muñoz-Garay, C.4    Sánchez5
  • 19
    • 0037134485 scopus 로고    scopus 로고
    • Heliothis virescens and Manduca sexta lipid rafts are involved in Cry1A toxin binding to the midgut epithelium and subsequent pore formation
    • Zhuang M, Oltean DI, Gómez I, Pullikuth AK, Soberón M, et al. (2002) Heliothis virescens and Manduca sexta lipid rafts are involved in Cry1A toxin binding to the midgut epithelium and subsequent pore formation. J Biol Chem 277: 13863-13872.
    • (2002) J Biol Chem , vol.277 , pp. 13863-13872
    • Zhuang, M.1    Oltean, D.I.2    Gómez, I.3    Pullikuth, A.K.4    Soberón, M.5
  • 20
    • 33745597608 scopus 로고    scopus 로고
    • A mechanism of cell death involving an adenylyl cyclase/PKA signaling pathway is induced by the Cry1Ab toxin of Bacillus thuringiensis
    • Zhang X, Candas M, Griko NB, Taissing R, Bulla LA Jr (2006) A mechanism of cell death involving an adenylyl cyclase/PKA signaling pathway is induced by the Cry1Ab toxin of Bacillus thuringiensis. Proc Natl Acad Sci USA 103: 9897-9902.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 9897-9902
    • Zhang, X.1    Candas, M.2    Griko, N.B.3    Taissing, R.4    Bulla Jr, L.A.5
  • 21
    • 34547138902 scopus 로고    scopus 로고
    • Bacillus thuringiensis Cry1Ab mutants affecting oligomer formation are non toxic to Manduca sexta larvae
    • Jiménez-Juárez N, Muñoz-Garay C, Gómez I, Saab-Rincón G, Damian-Alamazo JY, et al. (2007) Bacillus thuringiensis Cry1Ab mutants affecting oligomer formation are non toxic to Manduca sexta larvae. J Biol Chem 282: 21222-21229.
    • (2007) J Biol Chem , vol.282 , pp. 21222-21229
    • Jiménez-Juárez, N.1    Muñoz-Garay, C.2    Gómez, I.3    Saab-Rincón, G.4    Damian-Alamazo, J.Y.5
  • 22
    • 43049150073 scopus 로고    scopus 로고
    • Cysteine scanning mutagenesis of α-4 a putative pore lining helix of the Bacillus thuringiensis insecticidal toxin Cry1Aa
    • Girard F, Vachon V, Préfontaine G, Marceau L, Su Y, et al. (2008) Cysteine scanning mutagenesis of α-4 a putative pore lining helix of the Bacillus thuringiensis insecticidal toxin Cry1Aa. Appl Environm Microbiol 74: 2565-2572.
    • (2008) Appl Environm Microbiol , vol.74 , pp. 2565-2572
    • Girard, F.1    Vachon, V.2    Préfontaine, G.3    Marceau, L.4    Su, Y.5
  • 23
    • 8144229487 scopus 로고    scopus 로고
    • Helix 4 mutants of the Bacillus thuringiensis insecticidal toxin Cry1Aa display altered poreforming abilities
    • Vachon V, Préfontaine G, Rang C, Coux F, Juteau M, et al. (2004) Helix 4 mutants of the Bacillus thuringiensis insecticidal toxin Cry1Aa display altered poreforming abilities. Appl Environm Microbiol 70: 6123-6130.
    • (2004) Appl Environm Microbiol , vol.70 , pp. 6123-6130
    • Vachon, V.1    Préfontaine, G.2    Rang, C.3    Coux, F.4    Juteau, M.5
  • 24
    • 0026785278 scopus 로고
    • Localized mutagenesis defines regions of the Bacillus thuringiensis delta-endotoxin involved in toxicity and specificity
    • Wu D, Aronson AI (1992) Localized mutagenesis defines regions of the Bacillus thuringiensis delta-endotoxin involved in toxicity and specificity. J Biol Chem 267: 2311-2317.
    • (1992) J Biol Chem , vol.267 , pp. 2311-2317
    • Wu, D.1    Aronson, A.I.2
  • 25
    • 0033527563 scopus 로고    scopus 로고
    • Helix 4 of the Bacillus thuringiensis Cry1Aa toxin lines the lumen of the ion channel
    • Masson L, Tabashnik BE, Liu YB, Brousseau R, Schwartz JL (1999) Helix 4 of the Bacillus thuringiensis Cry1Aa toxin lines the lumen of the ion channel. J Biol Chem 274: 31996-32000.
    • (1999) J Biol Chem , vol.274 , pp. 31996-32000
    • Masson, L.1    Tabashnik, B.E.2    Liu, Y.B.3    Brousseau, R.4    Schwartz, J.L.5
  • 26
    • 0029993089 scopus 로고    scopus 로고
    • Mutagenesis of three surfaced loops of Bacillus thuringiensis insecticidal toxin reveals residues important for toxicity receptor recognition and possibly membrane insertion
    • Smedley DP, Ellar DJ (1996) Mutagenesis of three surfaced loops of Bacillus thuringiensis insecticidal toxin reveals residues important for toxicity receptor recognition and possibly membrane insertion. Microbiology 142: 1617-1624.
    • (1996) Microbiology , vol.142 , pp. 1617-1624
    • Smedley, D.P.1    Ellar, D.J.2
  • 27
    • 0029792870 scopus 로고    scopus 로고
    • Mutations at domain II loop 3 of Bacillus thuringiensis Cry1Aa and Cry1Ab δ-endotoxins suggest loop 3 is involved in initial binding to lepidopteran midgut
    • Rajamohan F, Hussain SA, Cotrill JA, Gould F, Dean DH (1996) Mutations at domain II loop 3 of Bacillus thuringiensis Cry1Aa and Cry1Ab δ-endotoxins suggest loop 3 is involved in initial binding to lepidopteran midgut. J Biol Chem 271: 25220-25226.
    • (1996) J Biol Chem , vol.271 , pp. 25220-25226
    • Rajamohan, F.1    Hussain, S.A.2    Cotrill, J.A.3    Gould, F.4    Dean, D.H.5
  • 28
    • 14844304661 scopus 로고    scopus 로고
    • Single amino acid mutations in the cadherin receptor from Heliothis virescens affect its toxin binding ability to Cry1A toxins
    • Xie R, Zhuang M, Ross LS, Gómez I, Oltean DI, et al. (2005) Single amino acid mutations in the cadherin receptor from Heliothis virescens affect its toxin binding ability to Cry1A toxins. J Biol Chem 280: 8416-8425.
    • (2005) J Biol Chem , vol.280 , pp. 8416-8425
    • Xie, R.1    Zhuang, M.2    Ross, L.S.3    Gómez, I.4    Oltean, D.I.5
  • 29
    • 60749126637 scopus 로고    scopus 로고
    • Enhancement of insecticidal activity of Bacillus thuringiensis Cry1A toxins by fragments of a toxin-binding cadherin correlates with oligomer formation
    • Pacheco S, Gómez I, Gill SS, Bravo A, Soberón M (2009) Enhancement of insecticidal activity of Bacillus thuringiensis Cry1A toxins by fragments of a toxin-binding cadherin correlates with oligomer formation. Peptides 30: 583-588.
    • (2009) Peptides , vol.30 , pp. 583-588
    • Pacheco, S.1    Gómez, I.2    Gill, S.S.3    Bravo, A.4    Soberón, M.5
  • 30
    • 0033868243 scopus 로고    scopus 로고
    • Proteolytic activation of receptor-bound anthrax protective antigen on macrophages promotes its internalization
    • Beauregard KE, Collier RJ, Swanson JA (2000) Proteolytic activation of receptor-bound anthrax protective antigen on macrophages promotes its internalization. Cell Microbiol 2: 251-258.
    • (2000) Cell Microbiol , vol.2 , pp. 251-258
    • Beauregard, K.E.1    Collier, R.J.2    Swanson, J.A.3
  • 31
    • 0024837128 scopus 로고
    • A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo
    • Singh Y, Chaudhary VK, Leppla SH (1989) A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo. J Biol Chem 264: 19103-19107.
    • (1989) J Biol Chem , vol.264 , pp. 19103-19107
    • Singh, Y.1    Chaudhary, V.K.2    Leppla, S.H.3
  • 32
    • 0037868151 scopus 로고    scopus 로고
    • Characterization of dominant negative forms of anthrax protective antigen
    • Yan M, Collier RJ (2003) Characterization of dominant negative forms of anthrax protective antigen. Mol Med 9: 46-51.
    • (2003) Mol Med , vol.9 , pp. 46-51
    • Yan, M.1    Collier, R.J.2
  • 33
    • 0020645619 scopus 로고
    • Bacillus thuringiensis var israelensis crystal delta-endotoxin: Effects on insect and mammalian cells in vitro and in vivo
    • Thomas WE, Ellar DJ (1983) Bacillus thuringiensis var israelensis crystal delta-endotoxin: effects on insect and mammalian cells in vitro and in vivo. J Cell Sci 60: 181-197.
    • (1983) J Cell Sci , vol.60 , pp. 181-197
    • Thomas, W.E.1    Ellar, D.J.2
  • 35
    • 45949125218 scopus 로고
    • Preparation and partial characterization of amino acid transporting brush border membrane vesicles from the larval midgut of the cabbage butterfly (Pieris brassicae)
    • Wolfersberger M, Luethy P, Maurer A, Parenti P, Sacchi FV, et al. (1987) Preparation and partial characterization of amino acid transporting brush border membrane vesicles from the larval midgut of the cabbage butterfly (Pieris brassicae). Comp Biochem Physiol 86A: 301-308.
    • (1987) Comp Biochem Physiol , vol.86 A , pp. 301-308
    • Wolfersberger, M.1    Luethy, P.2    Maurer, A.3    Parenti, P.4    Sacchi, F.V.5
  • 36
    • 0000559465 scopus 로고
    • Reconstitution of cell membrane structure in vitro and its transformation into an excitable system
    • Müeller P, Rudin DO, Tien HT, Westcott WC (1962) Reconstitution of cell membrane structure in vitro and its transformation into an excitable system. Nature 194: 979-980.
    • (1962) Nature , vol.194 , pp. 979-980
    • Müeller, P.1    Rudin, D.O.2    Tien, H.T.3    Westcott, W.C.4


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