Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 12, 2009, Pages 3324-3327

  Zhang, Jiquan ^a   Wang, Jianta ^a   Wu, Haoshu ^b   He, Yaoyao ^a   Zhu, Gaofeng ^a   Cui, Xing ^a   Tang, Lei ^a  

^a GUIZHOU MEDICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Diclofenac; Indomethacin; Insulin resistance; PPAR agonist

Indexed keywords

DICLOFENAC DERIVATIVE; INDOMETACIN DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; ROSIGLITAZONE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; INSULIN SENSITIVITY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

3T3-L1 CELLS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL DIFFERENTIATION; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; DRUG DESIGN; INDOMETHACIN; INSULIN; INSULIN RESISTANCE; MICE; PPAR GAMMA; RATS;

EID: 65749118570     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.050     Document Type: Article

References (13)

1. Amos A.F., McCarty D.J., and Zimmet P. Diabetes Metab. 14 (1997) S5
2. S W., G R., A G., R S., and King H. Diabetes Care 27 (2004) 1047
3. Hai L.Z., Hisashi M., Seikou N., and Masayuki Y. Bioorg. Med. Chem. Lett. 18 (2008) 3272
4. Harold E.L. Diabetes Metab. Res. Rev. 18 (2002) S23
5. Young G.S., et al. J. Med. Chem. 51 (2008) 6318
6. Magdalena S., et al. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 443
7. Shinkai H., et al. J. Med. Chem. 41 (1998) 1927
8. Li Z.B., et al. Bioorg. Med. Chem. Lett. 14 (2004) 3507
9. Yu J.H., Tang L., Yang Y.Y., and Ji R.R. Eur. J. Med. Chem. 43 (2008) 2428
10. Anne R., Rémy H., Dean W.H., Jean C.F., and Bart S. Biochim. Biophys. Acta 1771 (2007) 1065
11. 4: C, 69.20; H, 4.65; N, 3.23. Found: C, 69.35; H, 4.51; N, 3.50.
12. 5: C, 71.78; H, 5.05; N, 4.52. Found: C, 71.89; H, 5.22; N, 4.29.
13. 3: C, 62.70; H, 4.26; N, 3.48. Found: C, 60.52; H, 4.30; N, 4.29.