Is topical tissue plasminogen activator application effective on prevention of post-laminectomy epidural fibrosis? An experimental study

Neurological Research

Volumn 31, Issue 3, 2009, Pages 322-326

  Cekinmez, Melih ^a   Erdogan, Bulent ^a   Tufan, Kadir ^a   Sarica, Feyzi B ^a   Ozen, Ozlem ^a   Caner, Hakan ^a  

^a BASKENT UNIVERSITY   (Turkey)

Author keywords

Epidural fibrosis; Post laminectomy; Tissue plasminogen activator

Indexed keywords

ALTEPLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; EPIDURAL ABSCESS; EPIDURAL FIBROSIS; HISTOPATHOLOGY; LAMINECTOMY; MYELITIS; NONHUMAN; POSTOPERATIVE COMPLICATION; RAT; SCAR FORMATION; TISSUE NECROSIS;

ADMINISTRATION, TOPICAL; ANIMALS; CICATRIX; DRUG EVALUATION, PRECLINICAL; DURA MATER; FIBROSIS; LAMINECTOMY; POSTOPERATIVE COMPLICATIONS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE PLASMINOGEN ACTIVATOR;

EID: 65749111146     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/174313208X332940     Document Type: Article

References (25)

1. Ross JS, Obuchowski N, Zepp R. The postoperative lumbar spine: Evaluation of epidural scar over a 1-year period. Am J Neuroradiol 1998; 19: 183-186
2. Braverman DL, Slipman CW, Lenrow DA. Using gabapentin to treat failed back surgery syndrome caused by epidural fibrosis: A report of 2 cases. Arch Phys Med Rehabil 2001; 82: 691-693
3. Burton CV, Kirkaldy-Willis WH, Young-Hing K, et al. Causes of failure of surgery on the lumbar spine. Clin Orthop Relat Res 1981; 157: 191-199
4. Boot DA, Hughes SP. The prevention of adhesions after laminectomy. Adverse results of Zenoderm implantations into laminectomy sites in rabbits. Clin Orthop Relat Res 1987; 215: 296-302
5. Feild JR, McHenry H. The lumbar shield: A preliminary report. Neurosurgery 1978; 3: 26-36
6. Foulkes GD, Robinson JS, Jr. Intraoperative dexamethasone irrigation in lumbar microdiskectomy. Clin Orthop Relat Res 1990; 261: 224-228
7. Henderson R, Weir B, Davis L, et al. Attempted experimental modification of the postlaminectomy membrane by local instillation of recombinant tissue-plasminogen activator gel. Spine 1993; 18: 1268-1272
8. Kuivila TE, Berry JL, Bell GR, et al. Heparinized materials for control of the formation of the laminectomy membrane in experimental laminectomies in dogs. Clin Orthop Relat Res 1988; 236: 166-174
9. Lawson KJ, Malycky JL, Berry JL, et al. Lamina repair and replacement to control laminectomy membrane formation in dogs. Spine 1991; 16: 222-226
10. Lee CK, Alexander H. Prevention of postlaminectomy scar formation. Spine 1984; 9: 305-312 (Pubitemid 14109088)
11. Meyer RA, Jr, Gruber HE, Howard BA, et al. Safety of recombinant human bone morphogenetic protein-2 after spinal laminectomy in the dog. Spine 1999; 24: 747-754
12. Mikawa Y, Hamagami H, Shikata J, et al. An experimental study on prevention of postlaminectomy scar formation by the use of new materials. Spine 1986; 11: 843-846
13. Nussbaum CE, McDonald JV, Baggs RB. Use of vicryl (polyglactin 910) mesh to limit epidural scar formation after laminectomy. Neurosurgery 1990; 26: 649-654 (Pubitemid 20120714)
14. Petrie JL, Ross JS. Use of ADCON-L to inhibit postoperative peridural fibrosis and related symptomps following lumbar disc surgery: A preliminary report. Eur Spine J 1996; 5: 10-17
15. Vaquero J, Arias A, Oya S, et al. Effect of fibrin glue on postlaminectomy scar formation. Acta Neurochir (Wien) 1993; 120: 159-163
16. Lo H, Frederickson RC. Use of ADCON in neurosurgery: Preclinical review. Neurol Res 1999; 21: 27-32
17. Dogulu F, Kurt G, Emmez H, et al. Topical mitomycin C-induced inhibition of postlaminectomy peridural fibrosis in rabbits. J Neurosurg 2003; 99: 76-79
18. La Rocca H, MacNab I. The laminectomy membrane. Studies in its evolution, characteristics, effects and prophylaxis in dogs. J Bone Joint Surg Br 1974; 56: 545-550
19. Erdogan B, Sen O, Caner H, et al. Intravenous and local-intraarterial tissue-plasminogen activator in a rabbit model of acute thromboembolic stroke: Angiographic comparison. Adv Ther 2002; 19: 266-274 (Pubitemid 36249774)
20. Dullerud R, Graver V, Haakonsen M, et al. Influence of fibrinolytic factors on scar formation after lumbar discectomy. A magnetic resonance imaging follow-up study with clinical correlation performed 7 years after surgery. Spine 1998; 23: 1464-1469
21. Sen O, Kizilkilic O, Aydin MV, et al. The role of closed-suction drainage in preventing epidural fibrosis and its correlation with a new grading system of epidural fibrosis on the basis of MRI. Eur Spine J 2005; 14: 409-414
22. Saed GM, Diamond MP. Modulation of the expression of tissue plasminogen activator and its inhibitor by hypoxia in human peritoneal and adhesion fibroblasts. Fertil Steril 2003; 79: 164-168 (Pubitemid 36071256)
23. Cooper RG, Mitchell WS, Illingworth KJ, et al. The role of epidural fibrosis and defective fibrinolysis in the persistence of postlaminectomy back pain. Spine 1991; 16: 1044-1048
24. Klimiuk PS, Pountain GD, Keegan AL, et al. Serial measurements of fibrinolytic activity in acute low back pain and sciatica. Spine 1987; 12: 925-928
25. Csutak A, Tozser J, Bekesi L, et al. Plasminogen activator activity in tears after excimer laser photorefractive keratectomy. Invest Ophthalmol Vis Sci 2000; 41: 3743-3747