Novel C-seco-taxoids possessing high potency against paclitaxel-resistant cancer cell lines overexpressing class III β-tubulin

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 12, 2009, Pages 3300-3304

  Pepe, Antonella ^a   Sun, Liang ^a   Zanardi, Ilaria ^a   Wu, Xinyuan ^a   Ferlini, Cristiano ^b   Fontana, Gabriele ^c   Bombardelli, Ezio ^c   Ojima, Iwao ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b CATHOLIC UNIVERSITY   (Italy)

^c INDENA S P A   (Italy)

Author keywords

Tubulin; C seco taxoid; Paclitaxel resistance; Taxane

Indexed keywords

BETA TUBULIN; CISPLATIN; CYCLOSPORIN; DOXORUBICIN; IDN 5390; PACLITAXEL; SB CST 10101; SB CST 10102; SB CST 10104; SB CST 10201; SB CST 10202; SB CST 10204; TAXOID; TOPOTECAN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; DRUG CONFORMATION; DRUG EXPOSURE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50; MOLECULAR DYNAMICS; MOLECULAR MODEL; PROTEIN EXPRESSION; SIMULATION; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; COMPUTER SIMULATION; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; MODELS, MOLECULAR; OVARIAN NEOPLASMS; PACLITAXEL; TAXOIDS; TUBULIN;

EID: 65749106201     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.070     Document Type: Article

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