Selective serotonin reuptake inhibitor use during pregnancy and possible neonatal complications

Current Psychiatry Reports

Volumn 11, Issue 3, 2009, Pages 253-257

  Sackett, Jillan Cantor ^a   Weller, Ronald A ^b   Weller, Elizabeth B ^b  

^a THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; FLUOXETINE; NITRIC OXIDE; PAROXETINE; SEROTONIN; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; SERTRALINE;

ARTIFICIAL VENTILATION; BIRTH DEFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG PENETRATION; EXTRACORPOREAL OXYGENATION; FETUS MALFORMATION; HUMAN; MAJOR DEPRESSION; NEWBORN DISEASE; PERSISTENT PULMONARY HYPERTENSION; PREGNANCY; PREGNANCY OUTCOME; PUERPERAL DEPRESSION; REVIEW; RISK BENEFIT ANALYSIS; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; DEPRESSIVE DISORDER; FEMALE; HUMANS; MATERNAL-FETAL EXCHANGE; PREGNANCY; PREGNANCY COMPLICATIONS; RISK FACTORS; SEROTONIN UPTAKE INHIBITORS;

EID: 65749090986     PISSN: 15233812     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11920-009-0038-5     Document Type: Review

References (43)

1. Emergency psychiatric medicine. In Kaplan & Sadock Synopsis of Psychiatry, edn 10. Edited by Sadock B, Sadock V. Philadelphia: Lippincott Williams & Wilkins; 2007:897-923.
2. Oberlander T, Warburton W, Misri S, et al.: Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health data. Arch Gen Psychiatry 2006, 63:898-906.
3. Hasser C, Brizendlne L, Splelvogel A: SSRI use during pregnancy. Do antidepressants' benefits outweigh the risks? Curr Psychiatr 2006, 5:31-40.
4. Cohen L, Altshuler L, Harlow B, et al.: Relapse of major depression during pregnancy in women who maintain or discontinue antidepressant treatment. JAMA 2006, 296:499-507.
5. Gomez R, Fleming S, Keller J, et al.: The neuropsychological profile of psychotic major depression and its relationship to cortisol. Biol Psychiatry 2006, 60:472-478.
6. Bonari L, Pinto N, Ahn E, et al.: Perinatal risks of untreated depression during pregnancy. Can J Psychiatry 2004, 49:726-735.
7. Suri R, Altshuler L, Hellenmann G, et al.: Effects of antenatal depression and antidepressant treatment on gestational age at birth and risk of preterm birth. Am J Psychiatry 2007, 164:1206-1213.
8. Sullivan L, Fiellin D, O'Connor P: The prevalence and impact of alcohol problems in major depression: A systematic review. Am J Med 2005, 118:330-341.
9. Ostacher M: Comorbid alcohol and substance abuse dependence in depression: Impact on the outcome of antidepressant treatment. Psychiatr Clin North Am 2007, 30:69-76.
10. Peadon E, O'Leary C, Bower C, Elliott E: Impacts of alcohol use in pregnancy - the role of the GP. Aust Fam Physician 2007, 36:935-939.
11. Eustace L, Kang D,ACoombs D: Fetal alcohol syndrome: a growing concern for health care professionals. J Obstet Gynecol Neonatal Nurs 2003, 32:215-221.
12. Nulman I, Rovet J, Stewart D, et al.: Child development following exposure to tricyclic antidepressants or fluoxetine throughout fetal life: A prospective, controlled study. Am J Psychiatry 2002, 159:1889-1895.
13. Lucki I: The spectrum of behaviors influenced by serotonin. Biol Psychiatry 1998, 44:151-162.
14. Wong-Riley M, Liu Q: Neurochemical development of brain stem nuclei involved in the control of respiration. Respir Physiol Neurobiol 2005, 149:83-98.
15. McMahon T, Hood J, Nossaman B, Kadowitz P: Analysis of responses to serotonin in the pulmonary vascular bed of the cat. J Appl Physiol 1993, 75:93-102.
16. Sullivan C, Du L, Chu D, et al.: Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway. Proc Natl Acad Sci U S A 2003, 100:12331-12336.
17. Marcos E, Adnot S, Pham M, et al.: Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension. Am J Respir Crit Care Med 2003, 168:487-493.
18. Eddahibi S, Humbert M, Fadel E, et al.: Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hyperplasia. J Clin Invest 2001, 108:1141-1150.
19. Eddahibi S, Guignabert C, Barlier-Maur A, et al.: Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: Critical role for serotonin-induced smooth muscle hyperplasia. Circulation 2006, 113:1857-1864.
20. Gilbert-Barnes E: Respiratory system. In Potter's Pathology of the Fetus and Infant. Edited by Gilbert-Barnes E. Philadelphia: Mosby; 1997:712-773.
21. Hernandez-Diaz S, Van Marter L, Werler M, et al.: Risk factors for persistent pulmonary hypertension of the newborn. Pediatrics 2007, 120:e272-e282.
22. Stocker J: The respiratory system. In Pediatric Pathology, edn 2. Edited by Stocker J, Dehner L. Philadelphia: Lippincott Williams & Wilkins; 2001:445-592.
23. Chambers C, Hernandez-Diaz S, Van Marter L, et al.: Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn. N Engl J Med 2006, 354:579-587.
24. Farrow K, Fliman P, SteinhFrn R: The diseases treated with ECMO: focus on PPHN. Semin Perinatol 2005, 29:8-14.
25. Walsh-Sukys MC, Tyson JE, Wright LL, et al.: Persistent pulmonary hypertension of the newborn in the era before nitric oxide: Practice variation and outcomes. Pediatrics 2000, 105:14-20.
26. Chambers C, Johnson K, Dick L, et al.: Birth outcomes in pregnant women taking fluoxetine. N Engl J Med 1996, 335:1010-1015.
27. Hendrick V, Smith L, Suri R, et al.: Birth outcomes after prenatal exposure to antidepressant medication. Am J Obstet Gynecol 2003, 188:812-815.
28. Louik C, Lin AE, Werler MM, et al.: First-trimester use of selective serotonin-reuptake inhibitors and the risk of birth defects. N Engl J Med 2007, 356:2675-2682.
29. Alwan S, Reefhuis J, Rasmussen SA, et al.: Use of selective serotonin-reuptake inhibitors in pregnancy and the risk of birth defects. N Engl J Med 2007, 356:2684-2692.
30. GlaxoSmiBhKline: GSK medicine: bupropion and paroxetine. Epidemiology study: Preliminary report on bupropion in pregnancy and the occurrence of cardiovascular and major congenital malformation. Available at http://ctr.gsk.co.uk/summary/paroxetine/epip083.pdf. Accessed April 16, 2007.
31. Einarson A, Pistelli A, DeSantis M, et al.: Evaluation of the risk of congenital cardiovascular defects associated with use of paroxetine during pregnancy. Am J Psychiatry 2008, 165:749-752.
32. ACOG Committee on Obstetric Practice: ACOG Committee Opinion No. 354: treatment with selective serotonin reuptake inhibitors during pregnancy. Obstet Gynecol 2006, 108:1601-1603.
33. Oberlander T, Misri S, Fitzgerald C, et al.: Pharmacologic factors associated with transient neonatal symptoms following prenatal psychotropic medication exposure. J Clin Psychiatry 2004, 65:230-237.
34. Moses-Kolko E, Bogen D, Perel J, et al.: Neonatal signs after late in utero exposure to serotonin reuptake inhibitors. JAMA 2005, 293:2372-2383.
35. Malm H, Klaukka T, Neuvonen PJ: Risks associated with selective serotonin reuptake inhibitors in pregnancy. Obstet Gynecol 2005, 106:1289-1296.
36. Casper R, Fleisher B, Lee-Ancajas J, et al.: Follow-up of children of depressed mothers exposed or not exposed to antidepressants drugs during pregnancy. J Pediatr 2003, 142:402-408.
37. Nulman I, Rovet J, Stewart D, et al.: Neurodevelopment of children exposed in utero to antidepressant drugs. N Engl J Med 1997, 336:258-262.
38. Misri S, Reebye P, Kendrick K, et al.: Internalizing behaviors in 4-year-old children exposed in utero to psychotropic medications. Am J Psychiatry 2006, 163:1026-1032.
39. Spinelli MG, Endicott J: Controlled clinical trial of interpersonal psychotherapy versus parenting education program for depressed pregnant women. Am J Psychiatry 2003, 160:555-562.
40. Trivedi MH, Greer TL, Grannemann BD, et al.: Exercise as an augmentation strategy for treatment of major depression. J Psychiatr Pract 2006, 12:205-213.
41. Manber R, Allen J, Morris M: Alternative treatments for depression: empirical support and relevance to women. J Clin Psychiatry 2002, 63:628-639.
42. Machert A, Volz H, Stieglitz R, et al.: Phototherapy in nonseasonal depression. Biol Psychiatry 1991, 30:257-268.
43. Hendrick V, Altshuler L: Management of major depression during pregnancy. Am J Psychiatry 2002, 159: 1667-1673.