Serine Carboxypeptidases in Regulation of Vasoconstriction and Elastogenesis

Trends in Cardiovascular Medicine

Volumn 19, Issue 1, 2009, Pages 11-17

  Pshezhetsky, Alexey V ^a,b   Hinek, Aleksander ^c,d  

^a UNIVERSITY OF MONTREAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CARBOXYPEPTIDASE C; ELASTIN; SERINE CARBOXYPEPTIDASE;

ELASTIC FIBER; ELASTIN SYNTHESIS; ENDOTHELIUM CELL; EXPERIMENTAL STUDY; HUMAN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; REVIEW; VASOCONSTRICTION;

BETA-GALACTOSIDASE; CARBOXYPEPTIDASES; CARBOXYPEPTIDASES A; CARDIOMYOPATHIES; ELASTIC TISSUE; ELASTIN; ENZYME ACTIVATION; GLYCOCONJUGATES; HUMANS; HYPERTENSION; LYSOSOMAL STORAGE DISEASES; NEURAMINIDASE; VASOCONSTRICTION;

EID: 65649148301     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcm.2009.03.002     Document Type: Review

References (40)

1. Amiri F., Virdis A., Neves M.F., et al. Endothelium-restricted overexpression of human endothelin-1 causes vascular remodelling and endothelial dysfunction. Circulation 110 (2004) 2233-2240
2. Arribas S.M., Hinek A., and González M.C. Elastic fibres and vascular structure in hypertension. Pharmacol Ther 111 (2006) 771-791
3. Caciotti A., Donati M.A., Bardelli T., et al. Primary and secondary elastin-binding protein defect leads to impaired elastogenesis in fibroblasts from GM1-gangliosidosis patients. Am J Pathol 167 (2005) 1689-1698
4. Chen S., and Gardner D.G.L. Retinoic acid uses divergent mechanisms to activate or suppress mitogenesis in rat aortic smooth muscle cells. J Clin Invest 102 (1998) 653-662
5. Chen J., Streb J.W., Maltby K.M., et al. Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cells. J Biol Chem 276 (2001) 34175-34181
6. Dangel J.H. Cardiovascular changes in children with mucopolysaccharide storage diseases and related disorders-clinical and echocardiographic findings in 64 patients. Eur J Pediatr 157 (1998) 534-538
7. D'Azzo A., Hoogeveen A., Reuser A.J., et al. Molecular defect in combined β-galactosidase and neuraminidase deficiency in man. Proc Natl Acad Sci U S A 79 (1982) 4535-4539
8. D'Azzo A., Andria G., Strisciuglio G., and Galjaard H. Galactosialidosis. In: Scriver C.R., Beaudet A.L., Sly W.S., and Valle D. (Eds). The metabolic and molecular bases of inherited disease (2001), McGraw-Hill, New York 3811-3826
9. Factor S.M., Biempica L., and Goldfischer S. Coronary intimal sclerosis in Morquio's syndrome. Virchows Arch A Pathol Anat Histol 379 (1978) 1-10
10. Goraca A. New views on the role of endothelin. Endocr Regul 36 (2002) 161-167
11. Guertl B., Noehammer C., and Hoefler G. Metabolic cardiomyopathies. Int J Exp Pathol 81 (2000) 349-372
12. Harris J., Schwinn N., Mahoney J.A., et al. A vitellogenic-like carboxypeptidase expressed by human macrophages is localized in endoplasmic reticulum and membrane ruffles. Int J Exp Pathol 87 (2006) 29-39
13. Hinek A. Biological roles of the non-integrin elastin/laminin receptor. Biol Chem 377 (1996) 471-480
14. Hinek A., Rabinovitch M., Keeley F., et al. The 67-kD elastin/laminin-binding protein is related to an enzymatically inactive, alternatively spliced form of β-galactosidase. J Clin Invest 91 (1993) 1198-1205
15. Hinek A., Zhang S., Smith A.C., and Callahan J.W. Impaired elastic-fiber assembly by fibroblasts from patients with either Morquio B disease or infantile GM1-gangliosidosis is linked to deficiency in the 67-kD spliced variant of beta-galactosidase. Am J Hum Genet 67 (2000) 23-36
16. Hinek A., Pshezhetsky A.V., von Itzstein M., and Starcher B. Lysosomal sialidase (neuraminidase-1) is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assembly. J Biol Chem 281 (2006) 3698-3710
17. Itoh K., Kase R., Shimmoto M., et al. Protective protein as an endogenous endothelin degradation enzyme in human tissues. J Biol Chem 270 (1995) 515-518
18. Jackman H.L., Morris P.W., Rabito S.F., et al. Inactivation of endothelin-I by an enzyme of the vascular endothelial cells. Hypertension 21 (1993) 925-928
19. Jackman H.L., Massad M.G., Sekosan M., et al. Angiotensin 1-9 and 1-7 release in human heart: role of cathepsin A. Hypertension 39 (2002) 976-981
20. Keith I.M. The role of endogenous lung neuropeptides in regulation of the pulmonary circulation. Physiol Res 49 (2000) 519-537
21. Kiely D.G., Cargill R.I., Struthers A.D., and Lipworth B.J. Cardiopulmonary effects of endothelin-1 in man. Cardiovasc Res 33 (1997) 378-386
22. Kokkonen J.O., Saarinen J., and Kovanen P.T. Regulation of local angiotensin II formation in the human heart in the presence of interstitial fluid. Inhibition of chymase by protease inhibitors of interstitial fluid and of angiotensin-converting enzyme by Ang-(1-9) formed by heart carboxypeptidase A-like activity. Circulation 95 (1997) 1455-1463
23. Kollmann K., Mutenda K.E., Balleininger M., et al. Identification of novel lysosomal matrix proteins by proteome analysis. Proteomics 5 (2005) 3966-3978
24. Kollmann K., Damme M., Deuschl F., et al. Molecular characterization and gene disruption of mouse lysosomal putative serine carboxypeptidase. FEBS J (2009) [electronic publication ahead of print]
25. Kyllerman M., Mansson J.E., Westphal O., et al. Infantile galactosialidosis presenting with congenital adrenal hyperplasia and renal hypertension. Pediatr Neurol 9 (1993) 318-322
26. Lee T.H., Streb J.W., Georger M.A., and Miano J.M. Tissue expression of the novel serine carboxypeptidase Scpep1. J Histochem Cytochem 54 (2006) 701-711
27. Mahoney J.A., Ntolosi B., DaSilva R.P., et al. Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages. Genomics 72 (2001) 243-251
28. Morishita R., Higaki J., and Ogihara T. Endothelin stimulates aldosterone biosynthesis by dispersed rabbit adreno-capsular cells. Biochem Biophys Res Commun 160 (1989) 628-632
29. Morreau H., Galjart N.J., Gillemans N., et al. Alternative splicing of β-galactosidase mRNA generates the classic lysosomal enzyme and a β-galactosidase-related protein. J Biol Chem 264 (1989) 20655-20663
30. Nordborg C., Kyllerman M., Conradi N., and Mansson J.E. Early-infantile galactosialidosis with multiple brain infarctions: morphological, neuropathological and neurochemical findings. Acta Neuropathol 93 (1997) 24-33
31. Privitera S., Prody C.A., Callahan J.W., and Hinek A. The 67-kDa enzymatically inactive alternatively spliced variant of β-galactosidase is identical to the elastin/laminin-binding protein. J Biol Chem 273 (1998) 6319-6326
32. Pshezhetsky A.V. Lysosomal carboxypeptidase A. In: Barrett A.J., Rawlings N.D., and Woessner J.F. (Eds). Handbook of proteolytic enzymes. 2nd ed. (2004), Academic Press, London, UK 1923-1929
33. Pshezhetsky A.V., and Potier M. Association of N-acetyl-galactosamine-6-sulfate sulfatase with the multienzyme lysosomal complex of β-galactosidase, cathepsin A and neuraminidase: possible implication for intralysosomal catabolism of keratan sulfate. J Biol Chem 271 (1996) 28359-28365
34. Satake A., Itoh K., Shimmoto M., et al. Distribution of lysosomal protective protein in human tissues. Biochem Biophys Res Commun 205 (1994) 38-43
35. Seyrantepe V., Hinek A., Peng J., et al. Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1. Circulation 117 (2008) 1973-1981
36. Starcher B., d'Azzo A., Keller P.W., et al. Neuraminidase-1 is required for the normal assembly of elastic fibers. Am J Physiol Lung Cell Mol Physiol 295 (2008) L637-L647
37. Turner A.J., and Murphy L.J. Molecular pharmacology of endothelin converting enzymes. Biochem Pharmacol 51 (1996) 91-102
38. Van der Horst G.T., Galjart N.J., D'Azzo A., et al. Identification and in vitro reconstitution of lysosomal neuraminidase from human placenta. J Biol Chem 264 (1989) 1317-1322
39. Yamamoto Y., Hake C.A., Martin B.M., et al. Isolation, characterization, and mapping of a human acid β-galactosidase cDNA. DNA Cell Biol 9 (1990) 119-127
40. Yanagisawa M., and Masaki T. Molecular biology and biochemistry of the endothelins. Trends Pharmacol Sci 10 (1989) 374-378