Characterization of an alternatively spliced GADD45a GADD45a1 isoform in arsenic-treated epithelial cells

Molecular Carcinogenesis

Volumn 48, Issue 5, 2009, Pages 454-464

  Zhang, Yadong ^a   Beezhold, Kevin ^a   Castranova, Vince ^a   Shi, Xianglin ^a,b   Chen, Fei ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alternative splicing; Arsenic; GADD45a; GADD45a1; Prometaphase

Indexed keywords

AMINO ACID; ARSENIC; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45 ALPHA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45 ALPHA1; MESSENGER RNA; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; GADD45A PROTEIN, HUMAN; ISOPROTEIN; NUCLEAR PROTEIN; PRIMER DNA;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; BRONCHUS MUCOSA; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL GROWTH; CELL PROLIFERATION; CHEMICAL ANALYSIS; CONTROLLED STUDY; DNA SEQUENCE; EMBRYO; EPITHELIUM CELL; EXON; FEMALE; GENE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMETAPHASE; PROTEIN FUNCTION; AMINO ACID SEQUENCE; CHEMISTRY; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; WESTERN BLOTTING;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ARSENIC; BASE SEQUENCE; BLOTTING, WESTERN; CELL CYCLE; CELL CYCLE PROTEINS; CELL PROLIFERATION; DNA PRIMERS; EPITHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN ISOFORMS; RNA, MESSENGER;

EID: 65649144219     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20483     Document Type: Article

References (16)

1. Hoffman B, Liebermann DA. Role of gadd45 in myeloid cells in response to hematopoietic stress. Blood Cells Mol Dis 2007;39:344-347. (Pubitemid 47484475)
2. Zhan Q. Gadd45a, a p53- and BRCA1-regulated stress protein, in cellular response to DNA damage. Mutat Res 2005;569:133-143. (Pubitemid 39643263)
3. Wang W, Huper G, Guo Y, Murphy SK, Olson JA, Jr., Marks JR. Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer. Oncogene 2005;24:2705-2714. (Pubitemid 40593098)
4. Barreto G, Schafer A, Marhold J, et al. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 2007;445:671-675.
5. Jin SG, Guo C, Pfeifer GP. GADD45A does not promote DNA demethylation. PLoS Genet 2008;4:e1000013.
6. Wang X, Wang RH, Li W, etal. Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure. J Biol Chem 2004;279: 29606-29614.
7. Fabbro M, Henderson BR. BARD1 regulates BRCA1-medi- ated transactivation of the p21(WAF1/CIP1) and Gadd45 promoters. Cancer Lett 2008;263:189-196.
8. Chen F, Lu Y, Zhang Z, et al. Opposite effect of NF-kappa B and c-Jun N-terminal kinase on p53-independent GADD45 induction by arsenite. J Biol Chem 2001;276:11414-11419.
9. Zheng X, Zhang Y, Chen YQ, Castranova V, Shi X, Chen F. Inhibition of NF-kappaB stabilizes gadd45alpha mRNA. Biochem Biophys Res Commun 2005;329:95-99. (Pubitemid 40255425)
10. Zerbini LF, Wang Y, Czibere A, et al. NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival. Proc Natl Acad Sci USA 2004;101:13618-13623.
11. ChenCY,GherziR,AndersenJS,etal. NucleolinandYB-1 are required for JNK-mediated interleukin-2 mRNAstabilization during T-cell activation. Genes Dev 2000;14:1236-1248.
12. Zhang Y, Bhatia D, Xia H, Castranova V, Shi X, Chen F.Nucleolin links to arsenic-induced stabilization of GADD45al- pha mRNA. Nucleic Acids Res 2006;34:485-495. (Pubitemid 43245430)
13. Chang Q, Bhatia D, Zhang Y, et al. Incorporation of an internal ribosome entry site-dependent mechanism in arsenic-induced GADD45 alpha expression. Cancer Res 2007;67:6146-6154.
14. Amanullah A, Azam N, Balliet A, et al. Cell signalling: Cell survival and a Gadd45-factor deficiency. Nature 2003;424: 741; discussion 2.
15. Hollander MC, Sheikh MS, Bulavin DV, et al. Genomic instability in Gadd45a-deficient mice. Nat Genet 1999;23: 176-184.
16. Sullivan M, Morgan DO. Finishing mitosis, one step at a time. Nat Rev Mol Cell Biol 2007;8:894-903. (Pubitemid 47622563)