Prevalence of dihydropteroate synthase mutations in Spanish patients with HIV-associated Pneumocystis pneumonia

Diagnostic Microbiology and Infectious Disease

Volumn 64, Issue 1, 2009, Pages 104-105

  Friaza, Vicente ^a   Montes Cano, Marco A ^a   Respaldiza, Nieves ^a   Morilla, Rubén ^a   Calderón, Enrique J ^a   de la Horra, Carmen ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; COTRIMOXAZOLE; DAPSONE; DIHYDROPTEROATE SYNTHASE; NUCLEOTIDE; PROLINE; SERINE; THREONINE; ANTIFUNGAL AGENT; FUNGAL PROTEIN;

ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC RESISTANCE; BINDING SITE; CLONING; DISEASE ASSOCIATION; DRUG RESISTANCE; ETHNICITY; FUNGAL DETECTION; GENE AMPLIFICATION; GENE MUTATION; GENE SEQUENCE; GENETIC EPIDEMIOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOCOMPROMISED PATIENT; LETTER; LUNG LAVAGE; MUTATION RATE; NONHUMAN; PNEUMOCYSTIS JIROVECI; PNEUMOCYSTIS PNEUMONIA; PREVALENCE; PRIORITY JOURNAL; SPAIN; ANTIFUNGAL RESISTANCE; DRUG EFFECT; GENETICS; ISOLATION AND PURIFICATION; MICROBIOLOGY; MISSENSE MUTATION; NOTE; PNEUMOCYSTIS;

ANTIFUNGAL AGENTS; DIHYDROPTEROATE SYNTHASE; DRUG RESISTANCE, FUNGAL; FUNGAL PROTEINS; HIV INFECTIONS; HUMANS; MUTATION, MISSENSE; PNEUMOCYSTIS; PNEUMONIA, PNEUMOCYSTIS; PREVALENCE; SPAIN;

EID: 65649113568     PISSN: 07328893     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2009.01.015     Document Type: Letter

References (10)

1. Alvarez-Martínez M.J., Moreno A., Miró J.M., Valls M.E., Rivas P.V., de Lazzari E., Sued O., Benito N., Domingo P., Ribera E., Santín M., Sirera G., Segura F., Vidal F., Rodríguez F., Riera M., Cordero M.E., Arribas J.R., Jiménez de Anta M.T., Gatell J.M., Wilson P.E., Meshnick S.R., and Spanish PCP Working Group. Pneumocystis jirovecii pneumonia in Spanish HIV-infected patients in the combined antiretroviral therapy era: prevalence of dihydropteroate synthase mutations and prognostic factors of mortality. Diagn. Microbiol. Infect. Dis. 62 (2008) 34-43
2. Calderón E.J., de la Horra C., Medrano F.J., López-Suarez A., Montes-Cano M.A., Respaldiza N., Elvira-González J., Martin-Juan J., Bascuñana A., and Varela J.M. Pneumocystis jiroveci isolates with dihydropteroate synthase (DHPS) mutations in patients with chronic bronchitis. Eur. J. Clin. Microbiol. Infect. 23 (2004) 545-549
3. Calderón E.J., de la Horra C., Montes-Cano M.A., Respaldiza N., Martín-Juan J., and Varela J.M. Resistencia genotípica a sulfamidas en pacientes con neumonía por Pneumocystis jiroveci. Med. Clin. (Barc). 122 (2004) 617-619
4. Esteves F., Montes-Cano M.A., de la Horra C., Costa M.C., Calderon E.J., Antunes F., and Matos O. Pneumocystis jirovecii multilocus genotyping profiles in patients from Portugal and Spain. Clin. Microbiol. Infect. 14 (2008) 356-362
5. Helweg-Larsen J., Eugen-Olsen J., and Lundgren B. Rapid detection of dihydropteroate polymorphism in AIDS-related Pneumocystis carinii pneumonia by restriction fragment length polymorphism. Scand. J. Infect. Dis. 32 (2000) 481-483
6. Huang L., Crothers K., Atzori C., Benfield T., Miller R., Rabodonirina M., and Helweg-Larsen J. Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance. Emerg. Infect. Dis. 10 (2004) 1721-1728
7. Kazanjian P., Locke A.B., Hossler P.A., Lane B.R., Bartlett M.S., Smith J.W., Cannon M., and Meshnick S.R. Pneumocystis carinii mutations associated with sulfa and sulfone prophylaxis failures in AIDS patients. AIDS 12 (1998) 873-878
8. Montes-Cano M.A., de la Horra C., Martín-Juan J., Varela J.M., Torronteras R., Respaldiza N., Medrano F.J., and Calderón E.J. Pneumocystis jiroveci genotypes in Spanish population. Clin. Infect. Dis. 39 (2004) 545-549
9. Nahimana A., Rabodonirina M., Zanetti G., Meneau I., Francioli P., Bille J., and Hauser P.M. Association between a specific Pneumocystis jiroveci Dihydropteroate synthase mutation and failure of pyrimethamine/sulfadoxine prophylaxis in human immunodeficiency virus-positive and -negative patients. J. Infect. Dis. 188 (2003) 1017-1023
10. Stein C.R., Poole C., Kazanjian P., and Meshnick S.R. Sulfa use, dihydropteroate synthase mutations, and Pneumocystis jirovecii pneumonia. Emerg. Infect. Dis. 10 (2004) 1760-1765