Platelet-poor plasma stimulates the proliferation but inhibits the differentiation of rat osteoblastic cells in vitro

Clinical Oral Implants Research

Volumn 20, Issue 6, 2009, Pages 616-623

  Hamdan, Ahmad Abdel Salam ^a,b,c   Loty, Sabine ^a,b,c   Isaac, Juliane ^a,b,c   Bouchard, Philippe ^c   Berdal, Ariane ^a,b,c   Sautier, Jean Michel ^a,b,c  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b INSERM   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Differentiation; Osteoblast; Platelet poor plasma (PPP); Proliferation; Tissue engineering

Indexed keywords

ALKALINE PHOSPHATASE; OSTEOCALCIN; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECT; METABOLISM; OSTEOBLAST; PHYSIOLOGY; PLASMA; RAT; SPRAGUE DAWLEY RAT; THROMBOCYTE;

ALKALINE PHOSPHATASE; ANIMALS; BLOOD PLATELETS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CULTURE MEDIA; OSTEOBLASTS; OSTEOCALCIN; PLASMA; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION FACTORS;

EID: 65649107252     PISSN: 09057161     EISSN: 16000501     Source Type: Journal    
DOI: 10.1111/j.1600-0501.2008.01687.x     Document Type: Article

References (56)

1. Aghaloo, T.L., Moy, P.K. Freymiller, E.G. (2005) Evaluation of platelet-rich plasma in combination with freeze-dried bone in the rabbit cranium. A pilot study. Clinical Oral Implant Research 16 : 250 257. (Pubitemid 41613446)
2. Aïoub, M., Lézot, F., Molla, M., Castaneda, B., Robert, B., Goubin, G., Néfussi, J.-R. Berdal, A. (2007) Msx2 -/- transgenic mice develop compound amelogenesis imperfecta, dentinogenesis imperfecta and periodental osteopetrosis. Bone 41 : 851 859. (Pubitemid 47576834)
3. Arpornmaeklong, P., Kochel, M., Depprich, R., Kübler, N.R. Würzler, K.K. (2004) Influence of platelet-rich plasma (PRP) on osteogenic differentiation of rat bone marrow stromal cells. An in vitro study. International Journal of Oral and Maxillofacial Surgery 33 : 60 70. (Pubitemid 38035495)
4. Butterfield, K.J., Bennett, J., Gronowicz, G. Adams, D. (2005) Effect of platelet-rich plasma with autogenous bone graft for maxillary sinus augmentation in a rabbit model. Journal of Oral and Maxillofacial Surgery 63 : 370 376. (Pubitemid 40269644)
5. Camargo, P.M., Lekovic, V., Weinlaender, M., Vasilic, N., Madzarevic, M. Kenney, E.B. (2002) Platelet-rich plasma and bovine porous bone mineral combined with guided tissue regeneration in the treatment of intrabony defects in humans. Journal of Periodontal Research 37 : 300 306.
6. Cheung, W.S. Griffin, T.J. (2004) A comparative study of root coverage with connective tissue and platelet concentrate grafts: 8-month results. Journal of Periodontology 75 : 1678 1687. (Pubitemid 40260020)
7. Choi, B.-H., Im, C.-J., Huh, J.-Y., Suh, J.-J. Lee, S.-H. (2004) Effect of platelet-rich plasma on bone regeneration in autogenous bone graft. International Journal of Oral and Maxillofacial Surgery 33 : 56 59. (Pubitemid 38035494)
8. Choi, B.-H., Zhu, S.-J., Kim, B.-Y., Huh, J.-Y., Lee, S.-H. Jung, J.-H. (2005) Effect of platelet-rich plasma (PRP) concentration on the viability and proliferation of alveolar bone cells: an in vitro study. International Journal of Oral and Maxillofacial Surgery 34 : 420 424. (Pubitemid 40631358)
9. Christgau, M., Moder, D., Hiller, K.A., Dada, A., Schmitz, G. Schmalz, G. (2006) Growth factors and cytokines in autologous platelet concentrates and their correlation to periodontal regeneration outcomes. Journal of Clinical Periodontology 33 : 837 845.
10. Cochran, D.L., Jones, A.A., Lilly, L.C., Fiorellini, J.P. Howell, H. (2000) Evaluation of recombinant human bone morphogenetic protein-2 in oral applications including the use of endosseous implants: 3-year results of a pilot study in humans. Journal of Periodontology 71 : 1241 1257.
11. Consolo, U., Zaffe, D., Bertoldi, C. Ceccherelli, G. (2007) Platelet-rich plasma activity on maxillary sinus floor augmentation by autologous bone. Clinical Oral Implant Research 18 : 252 262.
12. Dodig, M., Tadic, T., Kronenberg, M.S., Dacic, S., Liu, Y.H., Maxson, R., Rowe, D.W. Lichtler, A.C. (1999) Ectopic Msx2 overexpression inhibits and Msx2 antisense stimulates calvarial osteoblast differentiation. Developmental Biology 209 : 298 307.
13. Döri, F., Nikolidakis, D., Húszár, T., Arweiler, N.B., Gera, I. Sculean, A. (2008) Effect of platelet-rich plasma on the healing of intrabony defects treated with an enamel matrix protein derivative and a natural bone mineral. Journal of Clinical Periodontology 35 : 44 50.
14. Ducy, P., Desbois, C., Boyce, B., Pinero, G., Story, B., Dunstan, C., Smith, E., Bonadio, J., Goldestein, S., Gundberg, C., Bradley, A. Karsenty, G. (1996) Increased bone formation in osteocalcin deficiency mice. Nature 382 : 448 452. (Pubitemid 26264860)
15. Everts, P.A., Brown Mahoney, C., Hoffmann, J.J., Schönberger, J.P., Box, H.A., van Zundert, A. Knape, J.T. (2006) Platelet-rich plasma preparation using three devices: implications for platelet activation and platelet growth factor release. Growth Factors 24 : 165 171. (Pubitemid 44669347)
16. Fennis, J.P.M., Stoelinga, P.J.W. Jansen, J.A. (2004) Mandibular reconstruction: a histological and histomorphometric study on the use of autogenous scaffolds, particulate cortico-cancellous bone grafts and platelet rich plasma in goats. International Journal of Oral and Maxillofacial Surgery 33 : 48 55. (Pubitemid 38035493)
17. Ferguson, C., Alpern, E., Miclau, T. Helms, J.A. (1999) Does adult fracture recapitulate embryonic skeletal formation? Mechanisms of Development 87 : 57 66. (Pubitemid 29428086)
18. Ferreira, C.F., Carriel Gomes, M.C., Filho, J.S., Granjeiro, J.M., Oliveira Simões, C.M. Magini, R.de S. (2005) Platelet-rich plasma influences on human osteoblasts growth. Clinical Oral Implant Research 16 : 456 460.
19. Froum, S.J., Wallace, S.S., Tarnow, D.P. Cho, S.C. (2002) Effect of platelet-rich plasma on bone growth and osseointegration in human maxillary sinus grafts: three bilateral case reports. International Journal of Periodontics Restorative Dentistry 22 : 45 53.
20. Goto, H., Matsuyama, T., Miyamoto, M., Yonamine, Y. Izumi, Y. (2006) Platelet-rich plasma/osteoblasts complex induces bone formation via osteoblastic differentiation following subcutaneous transplantation. Journal of Periodontal Research 41 : 455 462.
21. Graziani, F., Ivanovski, S., Cei, S., Ducci, F., Tonetti, M. Gabriele, M. (2006) The in vitro effect of different PRP concentrations on osteoblasts and fibroblasts. Clinical Oral Implant Research 17 : 212 219.
22. Grigoriadis, A.E., Heersche, J.N.M. Aubin, J.E. (1988) Differentiation fo muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone. Journal of Cell Biology 106 : 2139 2151. (Pubitemid 18180031)
23. Huang, L.H., Neiva, R.E.F., Soehren, S.E., Giannobile, W.V. Wang, H.L. (2005) The effect of platelet-rich plasma on the coronally advanced flap root coverage procedure: a pilot human trial. Journal of Periodontology 76 : 1768 1777. (Pubitemid 41645587)
24. Jung, R.E., Glauser, R., Scharer, P., Hammerle, C.H., Sailer, H.F. Weber, F.E. (2003) Effect of rhBMP-2 on guided bone regeneration in humans. Clinical Oral Implants Research 14 : 556 568.
25. Kanno, T., Takahashi, T., Tsujisawa, T., Ariyoshi, W. Nishihara, T. (2005) Platelet-rich plasma enhances human osteoblast-like cell proliferation and differentiation. Journal of Oral and Maxillofacial Surgery 63 : 362 369. (Pubitemid 40269643)
26. Kassolis, J.D., Rosen, P.S. Reynolds, M.A. (2000) Alveolar ridge and sinus augmentation utilizing platelet-rich plasma in combination with freeze-dried bone allograft: case series. Journal of Periodontology 71 : 1654 1661.
27. Kawase, T., Okuda, K., Wolff, L.F. Yoshie, H. (2003) Platelet-rich plasma-derived fibrin clot formation stimulates collagen synthesis in periodontal ligament and osteoblastic cells in vitro. Journal of Periodontology 74 : 858 864. (Pubitemid 36874119)
28. Keceli, H.G., Sengun, D., Berberòlu, A. Karabulut, E. (2008) Use of platelet gel with connective tissue grafts for root coverage: a randomized-controlled trial. Journal of Clinical Periodontology 35 : 255 262.
29. Kim, E.-S., Park, E.-J. Choung, P.-H. (2001) Platelet concentration and its effect on bone formation in calvarial defects: an experimental study in rabbits. Journal of Prosthetic Dentistry 86 : 428 433. (Pubitemid 33601433)
30. Komori, T., Yagi, H., Nomura, S., Yamagushi, A., Sasaki, K., Degushi, K., Shimizu, Y., Bronson, R.T., Gao, Y.H., Inada, M., Sato, M., Okamoto, R., Kitamura, Y., Yoshiki, S. Kishimoto, T. (1997) Targeted disruption of Cbfa1 results in complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89 : 755 764. (Pubitemid 27516178)
31. Lian, J.B., Stein, G.S., Javed, A., van Wijnen, A.J., Stein, J.L., Montecino, M., Hassan, M.Q., Gaur, T., Lengner, C.J. Young, D.W. (2006) Networks and hubs for the transcriptional control of osteoblastogenesis. Reviews in Endocrine and Metabolic Disorders 7 : 1 16. (Pubitemid 46044345)
32. Liu, Y., Tang, Z., Kundu, R.K., Wu, L., Luo, W., Zhu, D., Sangiori, F., Snead, M.L. Maxson, R.E. (1999) Msx2 gene dosage influences the number of proliferative osteogenic cells in growth centers of the developing murine skull: possible mechanism for Msx2 mediated craniosynostosis in humans. Developmental Biology 205 : 260 274. (Pubitemid 29066384)
33. MacNeil, R.L. Somerman, M.J. (1999) Development and regeneration of the periodontium: parallels and contrasts. Periodontology 2000 19 : 8 20.
34. Marx, R.E., Carlson, E.R., Eichstaedt, R.M., Schimmele, S.R., Strauss, J.E. Georgeff, K.R. (1998) Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics 85 : 638 646. (Pubitemid 128641964)
35. Meraw, S.J., Reeve, C.M., Lohse, C.M. Sioussat, T.M. (2000) Treatment of peri-implant defects with combination growth factor cement. Journal of Periodontology 71 : 8 13.
36. Nefussi, J.-R., Boy-Lefèvre, M.-L., Boulekbache, H. Forest, N. (1985) Mineralization in vitro of matrix formed by osteoblasts isolated by collagenase digestion. Differentiation 29 : 160 168. (Pubitemid 15045650)
37. Nevins, M., Giannobile, W.V., McGuire, M.K., Kao, R.T., Mellonig, J.T., Hinrichs, J.E., McAllister, B.S., Murphy, K.S., McClain, P.K., Nevins, M.L., Paquette, D.W., Han, T.J., Reddy, M.S., Lavin, P.T., Genco, R.J. Lynch, S.E. (2005) Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial. Journal of Periodontology 76 : 2205 2215. (Pubitemid 43116085)
38. Ogino, Y., Ayukawa, Y., Tsukiyama, Y. Koyano, K. (2005) The effect of platelet-rich plasma on the cellular reponse of rat bone marrow cells in vitro. Oral Surgery Oral Medicine Oral Pathology Oral Radiology Endodontics 100 : 302 307. (Pubitemid 41191341)
39. Okuda, K., Tai, H., Tanabe, K., Suzuki, H., Sato, T., Kawase, T., Saito, Y., Wolff, L.F. Yoshiex, H. (2005) Platelet-rich plasma combined with a porous hydroxyapatite graft for the treatment of intrabony periodontal defects in humans: a comparative controlled clinical study. Journal of Periodontology 76 : 890 898. (Pubitemid 40903829)
40. Otto, F., Thornell, A.P., Crompton, T., Denzel, A., Gilmour, K.C., Rosewell, I.R., Stamp, G.W., Beddington, R.S., Mundlos, S., Olsen, B.R., Selby, P.B. Owen, M.J. (1997) Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89 : 765 771. (Pubitemid 27516179)
41. Partridge, N.C., Alcorn, D., Michelangeli, V.P., Ryan, G. Martin, T.J. (1983) Morphological and biochemical characterization of four clonal osteogenic sarcoma cell lines of rat origin. Cancer Research 43 : 4308 4314.
42. Plachokova, A.S., van den Dolder, J., Stoelinga, P.J. Jansen, J.A. (2007) Early effect of platelet-rich plasma on bone healing in combination with an osteoconductive material in rat cranial defects. Clinical Oral Implant Research 18 : 244 251.
43. Polimeni, G., Xiropaidis, A.V. Wikesjö, U.M.E. (2006) Biology and principles of periodontal wound healing/regeneration. Periodontology 2000 41 : 30 47.
44. Raghoebar, G.M., Schortinghuis, J., Liem, R.S., Ruben, J.L., van der Wal, J.E. Vissink, A. (2005) Does platelet-rich plasma promote remodeling of autologous bone grafts used for augmentation of the maxillary sinus floor? Clinical Oral Implant Research 16 : 349 356. (Pubitemid 41679599)
45. Roldán, J.C., Jepsen, S., Schmidt, C., Knüppel, H., Rueger, D.C., Açil, Y. Terheyden, H. (2004) Sinus floor augmentation with simultaneous placement of dental implants in the presence of platelet-rich plasma or recombinant human bone morphogenetic protein-7. Clinical Oral Implant Research 15 : 716 723. (Pubitemid 40115760)
46. Roussy, Y., Bertrand Duchesne, M.P. Gagnon, G. (2007) Activation of human platelet-rich plasmas: effect on growth factors release, cell division and in vivo bone formation. Clinical Oral Implant Research 18 : 639 648.
47. Ryoo, H.M., Hoffmann, H.M., Beumer, T., Frenkel, B., Towler, D.A., Stein, G.S., Stein, J.L., van Wijnen, A.J. Lian, J.B. (1997) Stage specific expression of Dlx5 during osteoblast differentiation: involvement in regulation of osteocalcin gene expression. Molecular Endocrinology 11 : 1681 1694. (Pubitemid 27435416)
48. Sarment, D.P., Cooke, J.W., Miller, S.E., Jin, Q., McGuire, M.K., Kao, R.T., McClain, P.K., McAllister, B.S., Lynch, S.E. Giannobile, W.V. (2006) Effect of rhPDGF-BB on bone turnover during periodontal repair. Journal of Clinical Periodontology 33 : 135 140.
49. Saygin, N.E., Giannobile, W.V. Somerman, M.J. (2000) Molecular and cell biology of cementum. Periodontology 2000 24 : 73 98.
50. Selvig, K.A., Sorensen, R.G., Wozney, J.M. Wikesjo, U.M. (2002) Bone repair following recombinant human bone morphogenetic protein-2 stimulated periodontal regeneration. Journal of Periodontology 73 : 1020 1029.
51. Soffer, E., Ouhayoun, J.-P., Dosquet, C., Meunier, A. Anagnostou, F. (2004) Effects of platelet lysates on select bone cell functions. Clinical Oral Implant Research 15 : 581 588. (Pubitemid 40104954)
52. Sudo, H., Kodama, H.A., Amagai, Y., Yamamoto, S. Kasai, S. (1983) In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. Journal of Cell Biology 96 : 191 198. (Pubitemid 13155577)
53. Wikesjö, U.M., Razi, S.S., Sigurdsson, T.J., Tatakis, D.N., Lee, M.B., Ongpipattanakul, B., Nguyen, T. Hardwick, R. (1998) Periodontal repair in dogs: effect of recombinant human transforming growth factor beta 1 on guided tissue regeneration. Journal of Clinical Periodontology 30 : 705 714. (Pubitemid 128705296)
54. Wiltfang, J., Schlegel, K.A., Schultze-Mosgau, S., Nkenke, E., Zimmermann, R. Kessler, P. (2003) Sinus floor augmentation with beta-tricalcium phosphate (beta-TCP): does platelet-rich plasma promote its osseous integration and degradation? Clinical Oral Implant Research 14 : 213 218. (Pubitemid 37490681)
55. Wuthier, R.E. (1975) Effect of phospholipids on the transformation of amorphous calcium phosphate to hydroxyapatite in vitro. Calcified Tissue Research 19 : 197 210.
56. Yassibag-Berkman, Z., Tuncer, O., Subasioglu, T. Kantarci, A. (2007) Combined use of platelet-rich plasma and bone grafting with or without guided tissue regeneration in the treatment of anterior interproximal defects. Journal of Periodontology 78 : 801 809.